Resurrecting FUS: Adrenal Androgens as an Ultimate Cause of Hematuria, Periuria, Pollakuria, Stranguria, Urolithiasis and Obstruction in Neutered Cats
Although many authors have doubted that “feline urological syndrome” (FUS) describes a real pathogenetic entity, because it subsumes such a large variety of signs, Sumner's recent finding that urethral obstruction occurs most frequently in springtime adds to a large body of evidence that lower...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fvets.2018.00207/full |
| _version_ | 1811328066495971328 |
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| author | Brandon P. Reines Brandon P. Reines Robert A. Wagner |
| author_facet | Brandon P. Reines Brandon P. Reines Robert A. Wagner |
| author_sort | Brandon P. Reines |
| collection | DOAJ |
| description | Although many authors have doubted that “feline urological syndrome” (FUS) describes a real pathogenetic entity, because it subsumes such a large variety of signs, Sumner's recent finding that urethral obstruction occurs most frequently in springtime adds to a large body of evidence that lower urinary tract problems occur most commonly in late winter and spring. This suggests that FUS may be a unitary disorder, with a hormonal basis, driven by increasing day length. We argue that rising adrenal androgens (AA) in neutered cats induce stress, and other more concrete manifestations of FUS through androgen-driven mechanisms. |
| first_indexed | 2024-04-13T15:19:42Z |
| format | Article |
| id | doaj.art-275d335d525d4428852994c695ed341d |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-13T15:19:42Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-275d335d525d4428852994c695ed341d2022-12-22T02:41:43ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692018-09-01510.3389/fvets.2018.00207385581Resurrecting FUS: Adrenal Androgens as an Ultimate Cause of Hematuria, Periuria, Pollakuria, Stranguria, Urolithiasis and Obstruction in Neutered CatsBrandon P. Reines0Brandon P. Reines1Robert A. Wagner2Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United StatesSt. Francis Animal Hospital, North Huntingdon, PA, United StatesDepartment of Laboratory Animal Resources, University of Pittsburgh School of Medicine, Pittsburgh, PA, United StatesAlthough many authors have doubted that “feline urological syndrome” (FUS) describes a real pathogenetic entity, because it subsumes such a large variety of signs, Sumner's recent finding that urethral obstruction occurs most frequently in springtime adds to a large body of evidence that lower urinary tract problems occur most commonly in late winter and spring. This suggests that FUS may be a unitary disorder, with a hormonal basis, driven by increasing day length. We argue that rising adrenal androgens (AA) in neutered cats induce stress, and other more concrete manifestations of FUS through androgen-driven mechanisms.https://www.frontiersin.org/article/10.3389/fvets.2018.00207/fullcatsanimalsandrogensurethral obstructionurologic diseasesseasons |
| spellingShingle | Brandon P. Reines Brandon P. Reines Robert A. Wagner Resurrecting FUS: Adrenal Androgens as an Ultimate Cause of Hematuria, Periuria, Pollakuria, Stranguria, Urolithiasis and Obstruction in Neutered Cats Frontiers in Veterinary Science cats animals androgens urethral obstruction urologic diseases seasons |
| title | Resurrecting FUS: Adrenal Androgens as an Ultimate Cause of Hematuria, Periuria, Pollakuria, Stranguria, Urolithiasis and Obstruction in Neutered Cats |
| title_full | Resurrecting FUS: Adrenal Androgens as an Ultimate Cause of Hematuria, Periuria, Pollakuria, Stranguria, Urolithiasis and Obstruction in Neutered Cats |
| title_fullStr | Resurrecting FUS: Adrenal Androgens as an Ultimate Cause of Hematuria, Periuria, Pollakuria, Stranguria, Urolithiasis and Obstruction in Neutered Cats |
| title_full_unstemmed | Resurrecting FUS: Adrenal Androgens as an Ultimate Cause of Hematuria, Periuria, Pollakuria, Stranguria, Urolithiasis and Obstruction in Neutered Cats |
| title_short | Resurrecting FUS: Adrenal Androgens as an Ultimate Cause of Hematuria, Periuria, Pollakuria, Stranguria, Urolithiasis and Obstruction in Neutered Cats |
| title_sort | resurrecting fus adrenal androgens as an ultimate cause of hematuria periuria pollakuria stranguria urolithiasis and obstruction in neutered cats |
| topic | cats animals androgens urethral obstruction urologic diseases seasons |
| url | https://www.frontiersin.org/article/10.3389/fvets.2018.00207/full |
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