The Role of Exosome and the ESCRT Pathway on Enveloped Virus Infection
The endosomal sorting complex required for transport (ESCRT) system consists of peripheral membrane protein complexes ESCRT-0, -I, -II, -III VPS4-VTA1, and ALIX homodimer. This system plays an important role in the degradation of non-essential or dangerous plasma membrane proteins, the biogenesis of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/16/9060 |
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| author | Yichen Ju Haocheng Bai Linzhu Ren Liying Zhang |
| author_facet | Yichen Ju Haocheng Bai Linzhu Ren Liying Zhang |
| author_sort | Yichen Ju |
| collection | DOAJ |
| description | The endosomal sorting complex required for transport (ESCRT) system consists of peripheral membrane protein complexes ESCRT-0, -I, -II, -III VPS4-VTA1, and ALIX homodimer. This system plays an important role in the degradation of non-essential or dangerous plasma membrane proteins, the biogenesis of lysosomes and yeast vacuoles, the budding of most enveloped viruses, and promoting membrane shedding of cytokinesis. Recent results show that exosomes and the ESCRT pathway play important roles in virus infection. This review mainly focuses on the roles of exosomes and the ESCRT pathway in virus assembly, budding, and infection of enveloped viruses. The elaboration of the mechanism of exosomes and the ESCRT pathway in some enveloped viruses provides important implications for the further study of the infection mechanism of other enveloped viruses. |
| first_indexed | 2024-03-10T08:43:39Z |
| format | Article |
| id | doaj.art-275e6bc782a14673bba40af1609d1198 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:43:39Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-275e6bc782a14673bba40af1609d11982023-11-22T08:04:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216906010.3390/ijms22169060The Role of Exosome and the ESCRT Pathway on Enveloped Virus InfectionYichen Ju0Haocheng Bai1Linzhu Ren2Liying Zhang3College of Animal Sciences, Key Lab for Zoonoses Research, Ministry of Education, Jilin University, Changchun 130062, ChinaCollege of Animal Sciences, Key Lab for Zoonoses Research, Ministry of Education, Jilin University, Changchun 130062, ChinaCollege of Animal Sciences, Key Lab for Zoonoses Research, Ministry of Education, Jilin University, Changchun 130062, ChinaCollege of Animal Sciences, Key Lab for Zoonoses Research, Ministry of Education, Jilin University, Changchun 130062, ChinaThe endosomal sorting complex required for transport (ESCRT) system consists of peripheral membrane protein complexes ESCRT-0, -I, -II, -III VPS4-VTA1, and ALIX homodimer. This system plays an important role in the degradation of non-essential or dangerous plasma membrane proteins, the biogenesis of lysosomes and yeast vacuoles, the budding of most enveloped viruses, and promoting membrane shedding of cytokinesis. Recent results show that exosomes and the ESCRT pathway play important roles in virus infection. This review mainly focuses on the roles of exosomes and the ESCRT pathway in virus assembly, budding, and infection of enveloped viruses. The elaboration of the mechanism of exosomes and the ESCRT pathway in some enveloped viruses provides important implications for the further study of the infection mechanism of other enveloped viruses.https://www.mdpi.com/1422-0067/22/16/9060exosomeendosomal sorting complex required for transport (ESCRT)enveloped virus |
| spellingShingle | Yichen Ju Haocheng Bai Linzhu Ren Liying Zhang The Role of Exosome and the ESCRT Pathway on Enveloped Virus Infection International Journal of Molecular Sciences exosome endosomal sorting complex required for transport (ESCRT) enveloped virus |
| title | The Role of Exosome and the ESCRT Pathway on Enveloped Virus Infection |
| title_full | The Role of Exosome and the ESCRT Pathway on Enveloped Virus Infection |
| title_fullStr | The Role of Exosome and the ESCRT Pathway on Enveloped Virus Infection |
| title_full_unstemmed | The Role of Exosome and the ESCRT Pathway on Enveloped Virus Infection |
| title_short | The Role of Exosome and the ESCRT Pathway on Enveloped Virus Infection |
| title_sort | role of exosome and the escrt pathway on enveloped virus infection |
| topic | exosome endosomal sorting complex required for transport (ESCRT) enveloped virus |
| url | https://www.mdpi.com/1422-0067/22/16/9060 |
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