PROTECTIVE ROLE OF SYLIMARIN ON METHOTREXATE INDUCED HEPATO-NEPHROTOXICITY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

PROTECTIVE ROLE OF SYLIMARIN ON METHOTREXATE INDUCED HEPATO-NEPHROTOXICITY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Abstract Background:ALL is the most common childhood malignancy. ALL are treated with methotrexate (MTX) based chemotherapy protocols. MTX can cause unpredictable serious hepato-renal side effects. Sylimarin has antioxidant and anti-inflammatory activities, membrane stabilizing effect,stimulate tiss...

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Bibliographic Details
Main Author:	Adel Abd Elhaleim Hagag
Format:	Article
Language:	English
Published:	Mattioli1885 2016-09-01
Series:	Mediterranean Journal of Hematology and Infectious Diseases
Subjects:	Keywords: Sylimarin. Methotrexate Serum cystatin C Urinary N-acetyl-beta-D-glucosaminidase.
Online Access:	http://www.mjhid.org/index.php/mjhid/article/view/2625

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