Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial
Introduction: Poor adherence to pharmacological treatment is frequent in people with severe mental disorders and it often causes lack of effectiveness of many psychotropic drugs. Thus, efforts should be made to improve adherence to pharmacological treatments in patients with these disorders.Methods:...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1285383/full |
| _version_ | 1827589687355637760 |
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| author | Gaia Sampogna Mario Luciano Matteo Di Vincenzo Claudia Toni Enrico D’Ambrosio Antonio Rampino Alessandro Rossi Rodolfo Rossi Mario Amore Pietro Calcagno Alberto Siracusano Cinzia Niolu Liliana Dell’Osso Barbara Carpita LIFESTYLE Working Group Andrea Fiorillo |
| author_facet | Gaia Sampogna Mario Luciano Matteo Di Vincenzo Claudia Toni Enrico D’Ambrosio Antonio Rampino Alessandro Rossi Rodolfo Rossi Mario Amore Pietro Calcagno Alberto Siracusano Cinzia Niolu Liliana Dell’Osso Barbara Carpita LIFESTYLE Working Group Andrea Fiorillo |
| author_sort | Gaia Sampogna |
| collection | DOAJ |
| description | Introduction: Poor adherence to pharmacological treatment is frequent in people with severe mental disorders and it often causes lack of effectiveness of many psychotropic drugs. Thus, efforts should be made to improve adherence to pharmacological treatments in patients with these disorders.Methods: In this paper, based on the LIFESTYLE randomized, controlled multicentric trial, we aim to: 1) assess the level of adherence in a real-world sample of patients with severe mental disorders; 2) evaluate differences in treatment adherence according to patients’ socio-demographic and clinical characteristics; 3) evaluate the impact of an innovative psychosocial intervention, on patients’ adherence to treatments. The Lifestyle Psychosocial Group Intervention consists of group sessions, focused on different lifestyle behaviours, including healthy diet; physical activity; smoking habits; medication adherence; risky behaviours; and regular circadian rhythms. At end of each session a 20-min moderate physical activity is performed by the whole group.Results: The sample consists of 402 patients, mainly female (57.1%, N = 229), with a mean age of 45.6 years (±11.8). Less than 40% of patients reported a good adherence to pharmacological treatments. Adherence to treatments was not influenced by gender, age, diagnosis and duration of illness. At the end of the intervention, patients receiving the experimental intervention reported a significant improvement in the levels of adherence to treatments (T0: 35.8% vs. T3: 47.6%, p < 0.005). Patients practicing moderate physical activity reported a two-point improvement in the levels of adherence [odds ratio (OR): 1,542; 95% confidence intervals (CI): 1,157–2,055; p < 0.001], even after controlling for several confounding factors.Discussion: The experimental lifestyle intervention, which can be easily implemented in the routine clinical practice of mental health centres, was effective in improving adherence to pharmacological treatments. |
| first_indexed | 2024-03-09T01:05:28Z |
| format | Article |
| id | doaj.art-2763954e1d99494b9fcece5d2ffbdc87 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-09T01:05:28Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2763954e1d99494b9fcece5d2ffbdc872023-12-11T10:03:26ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-12-011410.3389/fphar.2023.12853831285383Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trialGaia Sampogna0Mario Luciano1Matteo Di Vincenzo2Claudia Toni3Enrico D’Ambrosio4Antonio Rampino5Alessandro Rossi6Rodolfo Rossi7Mario Amore8Pietro Calcagno9Alberto Siracusano10Cinzia Niolu11Liliana Dell’Osso12Barbara Carpita13LIFESTYLE Working GroupAndrea Fiorillo14Department of Psychiatry, University of Campania “L. Vanvitelli”, Naples, ItalyDepartment of Psychiatry, University of Campania “L. Vanvitelli”, Naples, ItalyDepartment of Psychiatry, University of Campania “L. Vanvitelli”, Naples, ItalyDepartment of Psychiatry, University of Campania “L. Vanvitelli”, Naples, ItalyDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, ItalyDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyDepartment of Psychiatry, University of Campania “L. Vanvitelli”, Naples, ItalyIntroduction: Poor adherence to pharmacological treatment is frequent in people with severe mental disorders and it often causes lack of effectiveness of many psychotropic drugs. Thus, efforts should be made to improve adherence to pharmacological treatments in patients with these disorders.Methods: In this paper, based on the LIFESTYLE randomized, controlled multicentric trial, we aim to: 1) assess the level of adherence in a real-world sample of patients with severe mental disorders; 2) evaluate differences in treatment adherence according to patients’ socio-demographic and clinical characteristics; 3) evaluate the impact of an innovative psychosocial intervention, on patients’ adherence to treatments. The Lifestyle Psychosocial Group Intervention consists of group sessions, focused on different lifestyle behaviours, including healthy diet; physical activity; smoking habits; medication adherence; risky behaviours; and regular circadian rhythms. At end of each session a 20-min moderate physical activity is performed by the whole group.Results: The sample consists of 402 patients, mainly female (57.1%, N = 229), with a mean age of 45.6 years (±11.8). Less than 40% of patients reported a good adherence to pharmacological treatments. Adherence to treatments was not influenced by gender, age, diagnosis and duration of illness. At the end of the intervention, patients receiving the experimental intervention reported a significant improvement in the levels of adherence to treatments (T0: 35.8% vs. T3: 47.6%, p < 0.005). Patients practicing moderate physical activity reported a two-point improvement in the levels of adherence [odds ratio (OR): 1,542; 95% confidence intervals (CI): 1,157–2,055; p < 0.001], even after controlling for several confounding factors.Discussion: The experimental lifestyle intervention, which can be easily implemented in the routine clinical practice of mental health centres, was effective in improving adherence to pharmacological treatments.https://www.frontiersin.org/articles/10.3389/fphar.2023.1285383/fulladherencephysical activitysevere mental disorderlifestylepersonalization |
| spellingShingle | Gaia Sampogna Mario Luciano Matteo Di Vincenzo Claudia Toni Enrico D’Ambrosio Antonio Rampino Alessandro Rossi Rodolfo Rossi Mario Amore Pietro Calcagno Alberto Siracusano Cinzia Niolu Liliana Dell’Osso Barbara Carpita LIFESTYLE Working Group Andrea Fiorillo Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial Frontiers in Pharmacology adherence physical activity severe mental disorder lifestyle personalization |
| title | Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial |
| title_full | Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial |
| title_fullStr | Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial |
| title_full_unstemmed | Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial |
| title_short | Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial |
| title_sort | physical activity influences adherence to pharmacological treatments in patients with severe mental disorders results from the multicentric randomized controlled lifestyle trial |
| topic | adherence physical activity severe mental disorder lifestyle personalization |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1285383/full |
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