Development of an ultrahigh resolution real time alpha particle imaging system for observing the trajectories of alpha particles in a scintillator
Abstract High-resolution imaging of alpha particles is required in the detection of alpha radionuclides in cells or small organs for the development of radio-compounds for targeted alpha-particle therapy or other purposes. We developed an ultrahigh resolution, real time alpha-particle imaging system...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-31748-9 |
| _version_ | 1797836401168875520 |
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| author | Seiichi Yamamoto Masao Yoshino Kei Kamada Ryuga Yajima Akira Yoshikawa Kohei Nakanishi Jun Kataoka |
| author_facet | Seiichi Yamamoto Masao Yoshino Kei Kamada Ryuga Yajima Akira Yoshikawa Kohei Nakanishi Jun Kataoka |
| author_sort | Seiichi Yamamoto |
| collection | DOAJ |
| description | Abstract High-resolution imaging of alpha particles is required in the detection of alpha radionuclides in cells or small organs for the development of radio-compounds for targeted alpha-particle therapy or other purposes. We developed an ultrahigh resolution, real time alpha-particle imaging system for observing the trajectories of alpha particles in a scintillator. The developed system is based on a magnifying unit and a cooled electron multiplying charge-coupled device (EM-CCD) camera, combined with a 100-µm-thick Ce-doped Gd3Al2Ga3O12 (GAGG) scintillator plate. Alpha particles from an Am-241 source were irradiated to the GAGG scintillator and imaged with the system. Using our system, we measured the trajectories of the alpha particles having different shapes in real time. In some of these measured trajectories, the line shapes of the alpha particles that flew in the GAGG scintillator were clearly observed. The lateral profiles of the alpha-particle trajectories were imaged with widths of ~ 2 µm. We conclude that the developed imaging system is promising for research on targeted alpha-particle therapy or other alpha particle detections that require high spatial resolution. |
| first_indexed | 2024-04-09T15:09:37Z |
| format | Article |
| id | doaj.art-2763b055e75c4d4f8eaaf5a098c5d11d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T15:09:37Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2763b055e75c4d4f8eaaf5a098c5d11d2023-04-30T11:17:24ZengNature PortfolioScientific Reports2045-23222023-04-011311810.1038/s41598-023-31748-9Development of an ultrahigh resolution real time alpha particle imaging system for observing the trajectories of alpha particles in a scintillatorSeiichi Yamamoto0Masao Yoshino1Kei Kamada2Ryuga Yajima3Akira Yoshikawa4Kohei Nakanishi5Jun Kataoka6Faculty of Science and Engineering, Waseda UniversityNew Industry Creation Hatchery Center, Tohoku UniversityNew Industry Creation Hatchery Center, Tohoku UniversityDepartment of Materials Science, Graduate School of Engineering, Tohoku UniversityC&A CorporationNagoya University Graduate School of MedicineFaculty of Science and Engineering, Waseda UniversityAbstract High-resolution imaging of alpha particles is required in the detection of alpha radionuclides in cells or small organs for the development of radio-compounds for targeted alpha-particle therapy or other purposes. We developed an ultrahigh resolution, real time alpha-particle imaging system for observing the trajectories of alpha particles in a scintillator. The developed system is based on a magnifying unit and a cooled electron multiplying charge-coupled device (EM-CCD) camera, combined with a 100-µm-thick Ce-doped Gd3Al2Ga3O12 (GAGG) scintillator plate. Alpha particles from an Am-241 source were irradiated to the GAGG scintillator and imaged with the system. Using our system, we measured the trajectories of the alpha particles having different shapes in real time. In some of these measured trajectories, the line shapes of the alpha particles that flew in the GAGG scintillator were clearly observed. The lateral profiles of the alpha-particle trajectories were imaged with widths of ~ 2 µm. We conclude that the developed imaging system is promising for research on targeted alpha-particle therapy or other alpha particle detections that require high spatial resolution.https://doi.org/10.1038/s41598-023-31748-9 |
| spellingShingle | Seiichi Yamamoto Masao Yoshino Kei Kamada Ryuga Yajima Akira Yoshikawa Kohei Nakanishi Jun Kataoka Development of an ultrahigh resolution real time alpha particle imaging system for observing the trajectories of alpha particles in a scintillator Scientific Reports |
| title | Development of an ultrahigh resolution real time alpha particle imaging system for observing the trajectories of alpha particles in a scintillator |
| title_full | Development of an ultrahigh resolution real time alpha particle imaging system for observing the trajectories of alpha particles in a scintillator |
| title_fullStr | Development of an ultrahigh resolution real time alpha particle imaging system for observing the trajectories of alpha particles in a scintillator |
| title_full_unstemmed | Development of an ultrahigh resolution real time alpha particle imaging system for observing the trajectories of alpha particles in a scintillator |
| title_short | Development of an ultrahigh resolution real time alpha particle imaging system for observing the trajectories of alpha particles in a scintillator |
| title_sort | development of an ultrahigh resolution real time alpha particle imaging system for observing the trajectories of alpha particles in a scintillator |
| url | https://doi.org/10.1038/s41598-023-31748-9 |
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