Features stereotactic radiosurgical treatment large brain metastatic lesions of the brain with hypoxic radiosensitizers
Objective: Follow the dynamics of early reduction of tumor volume after stereotactic radiosurgery using hypoxic radiosensitizers and without radiosensitization, a comparison of these data with predictor of prolonged local control and median follow-up.Materials and methods: 107 patients (1...
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| Format: | Article |
| Language: | English |
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Romodanov Neurosurgery Institute
2016-03-01
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| Series: | Ukrainian Neurosurgical Journal |
| Online Access: | https://theunj.org/article/view/61885 |
| _version_ | 1797348271516024832 |
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| author | Andrey Gryazov |
| author_facet | Andrey Gryazov |
| author_sort | Andrey Gryazov |
| collection | DOAJ |
| description |
Objective: Follow the dynamics of early reduction of tumor volume after stereotactic radiosurgery using hypoxic radiosensitizers and without radiosensitization, a comparison of these data with predictor of prolonged local control and median follow-up.Materials and methods: 107 patients (173 lesions) with large brain metastases (≥10cm3) accounted for the main and control group of our research. Of these, the basic group (with radiosensitizers) 77 included, in the control group — 30 patients. Of the 77 patients, 40 patients (66 lesions) was used as a radiosensitizer metronidazole (M+), 37 (60 lesions) — nimorazol (H+).The average volume of metastases was 20.0cm3 (range 10–60.0cm3). SRS in one fraction to the average dose of 14 Gy (range 10–18 Gy), conducted an average of 4 fractions (range 3–5 fractions), with a mean dose of 26.5 Gy (range 21–40 Gy).Are taken into account only those patients who have at least passed the first compulsory MRI investigation a week after the SRS, with a further observation of 1.5 and 3 months.Results: During the term of supervision in metastases which considerably diminished in a volume already in a week after SRS, the signs of local control and median follow-up, unlike a control group, without of radiosensitizers at which it was not marked early and rapid reduction of tumour (r = .003, OR = 0.424; 95% confidence interval, 0.203-0.935), also in a group with radiosensitization the indexes of survivability were higher (19.0 months against 10.0, 95% [CI], 12.876-22.124 and 7.330-12.670, р=.0008 аnd р=.0001, respectively).Conclusions: Early reduction large brain metastases week after radiosurgery using hypoxic radiosensitizers may be a predictor of long-term local tumor control. |
| first_indexed | 2024-03-08T12:03:23Z |
| format | Article |
| id | doaj.art-27643df02a2a4fd384ff53496799a39b |
| institution | Directory Open Access Journal |
| issn | 2663-9084 2663-9092 |
| language | English |
| last_indexed | 2024-03-08T12:03:23Z |
| publishDate | 2016-03-01 |
| publisher | Romodanov Neurosurgery Institute |
| record_format | Article |
| series | Ukrainian Neurosurgical Journal |
| spelling | doaj.art-27643df02a2a4fd384ff53496799a39b2024-01-23T13:31:37ZengRomodanov Neurosurgery InstituteUkrainian Neurosurgical Journal2663-90842663-90922016-03-011506010.25305/unj.61885Features stereotactic radiosurgical treatment large brain metastatic lesions of the brain with hypoxic radiosensitizersAndrey Gryazov0Romodanov Neurosurgery Institute, Kiev, Ukraine Objective: Follow the dynamics of early reduction of tumor volume after stereotactic radiosurgery using hypoxic radiosensitizers and without radiosensitization, a comparison of these data with predictor of prolonged local control and median follow-up.Materials and methods: 107 patients (173 lesions) with large brain metastases (≥10cm3) accounted for the main and control group of our research. Of these, the basic group (with radiosensitizers) 77 included, in the control group — 30 patients. Of the 77 patients, 40 patients (66 lesions) was used as a radiosensitizer metronidazole (M+), 37 (60 lesions) — nimorazol (H+).The average volume of metastases was 20.0cm3 (range 10–60.0cm3). SRS in one fraction to the average dose of 14 Gy (range 10–18 Gy), conducted an average of 4 fractions (range 3–5 fractions), with a mean dose of 26.5 Gy (range 21–40 Gy).Are taken into account only those patients who have at least passed the first compulsory MRI investigation a week after the SRS, with a further observation of 1.5 and 3 months.Results: During the term of supervision in metastases which considerably diminished in a volume already in a week after SRS, the signs of local control and median follow-up, unlike a control group, without of radiosensitizers at which it was not marked early and rapid reduction of tumour (r = .003, OR = 0.424; 95% confidence interval, 0.203-0.935), also in a group with radiosensitization the indexes of survivability were higher (19.0 months against 10.0, 95% [CI], 12.876-22.124 and 7.330-12.670, р=.0008 аnd р=.0001, respectively).Conclusions: Early reduction large brain metastases week after radiosurgery using hypoxic radiosensitizers may be a predictor of long-term local tumor control.https://theunj.org/article/view/61885 |
| spellingShingle | Andrey Gryazov Features stereotactic radiosurgical treatment large brain metastatic lesions of the brain with hypoxic radiosensitizers Ukrainian Neurosurgical Journal |
| title | Features stereotactic radiosurgical treatment large brain metastatic lesions of the brain with hypoxic radiosensitizers |
| title_full | Features stereotactic radiosurgical treatment large brain metastatic lesions of the brain with hypoxic radiosensitizers |
| title_fullStr | Features stereotactic radiosurgical treatment large brain metastatic lesions of the brain with hypoxic radiosensitizers |
| title_full_unstemmed | Features stereotactic radiosurgical treatment large brain metastatic lesions of the brain with hypoxic radiosensitizers |
| title_short | Features stereotactic radiosurgical treatment large brain metastatic lesions of the brain with hypoxic radiosensitizers |
| title_sort | features stereotactic radiosurgical treatment large brain metastatic lesions of the brain with hypoxic radiosensitizers |
| url | https://theunj.org/article/view/61885 |
| work_keys_str_mv | AT andreygryazov featuresstereotacticradiosurgicaltreatmentlargebrainmetastaticlesionsofthebrainwithhypoxicradiosensitizers |