Neuronal ferroptosis after intracerebral hemorrhage
Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of morbidity, mortality, and disability. It induces cell death that is responsible for the secondary brain injury (SBI). The underlying mechanism of SBI after ICH is still unclear, and whether it is related to iron overlo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.966478/full |
| _version_ | 1818537184410468352 |
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| author | Siying Ren Yue Chen Likun Wang Guofeng Wu |
| author_facet | Siying Ren Yue Chen Likun Wang Guofeng Wu |
| author_sort | Siying Ren |
| collection | DOAJ |
| description | Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of morbidity, mortality, and disability. It induces cell death that is responsible for the secondary brain injury (SBI). The underlying mechanism of SBI after ICH is still unclear, and whether it is related to iron overload is worthy to be discussed. Ferroptosis is an iron-dependent non-apoptotic modes of cell death and plays a particularly important role in the occurrence and progression of ICH. Many ICH-induced regulators and signalling pathways of ferroptosis have been reported as promising targets for treating ICH. In this article, we review the definition, characteristics, and inhibition methods of neuronal ferroptosis caused by iron deposition after ICH, and review the biomarkers for ferroptosis. |
| first_indexed | 2024-12-11T18:47:30Z |
| format | Article |
| id | doaj.art-276538dc71d143b08c0016ae4df329b1 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-11T18:47:30Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-276538dc71d143b08c0016ae4df329b12022-12-22T00:54:25ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-08-01910.3389/fmolb.2022.966478966478Neuronal ferroptosis after intracerebral hemorrhageSiying Ren0Yue Chen1Likun Wang2Guofeng Wu3Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaGraduate School of Guizhou Medical University, Guiyang, ChinaDepartment of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaIntracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of morbidity, mortality, and disability. It induces cell death that is responsible for the secondary brain injury (SBI). The underlying mechanism of SBI after ICH is still unclear, and whether it is related to iron overload is worthy to be discussed. Ferroptosis is an iron-dependent non-apoptotic modes of cell death and plays a particularly important role in the occurrence and progression of ICH. Many ICH-induced regulators and signalling pathways of ferroptosis have been reported as promising targets for treating ICH. In this article, we review the definition, characteristics, and inhibition methods of neuronal ferroptosis caused by iron deposition after ICH, and review the biomarkers for ferroptosis.https://www.frontiersin.org/articles/10.3389/fmolb.2022.966478/fullintracerebral hemorrhagesecondary brain injurycell deathferroptosisiron overloadoxidative damage |
| spellingShingle | Siying Ren Yue Chen Likun Wang Guofeng Wu Neuronal ferroptosis after intracerebral hemorrhage Frontiers in Molecular Biosciences intracerebral hemorrhage secondary brain injury cell death ferroptosis iron overload oxidative damage |
| title | Neuronal ferroptosis after intracerebral hemorrhage |
| title_full | Neuronal ferroptosis after intracerebral hemorrhage |
| title_fullStr | Neuronal ferroptosis after intracerebral hemorrhage |
| title_full_unstemmed | Neuronal ferroptosis after intracerebral hemorrhage |
| title_short | Neuronal ferroptosis after intracerebral hemorrhage |
| title_sort | neuronal ferroptosis after intracerebral hemorrhage |
| topic | intracerebral hemorrhage secondary brain injury cell death ferroptosis iron overload oxidative damage |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.966478/full |
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