Crosstalk between Glycogen-Selective Autophagy, Autophagy and Apoptosis as a Road towards Modifier Gene Discovery and New Therapeutic Strategies for Glycogen Storage Diseases

Crosstalk between Glycogen-Selective Autophagy, Autophagy and Apoptosis as a Road towards Modifier Gene Discovery and New Therapeutic Strategies for Glycogen Storage Diseases

Glycogen storage diseases (GSDs) are rare metabolic monogenic disorders characterized by an excessive accumulation of glycogen in the cell. However, monogenic disorders are not simple regarding genotype–phenotype correlation. Genes outside the major disease-causing locus could have modulatory effect...

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Bibliographic Details
Main Authors: Marina Andjelkovic, Anita Skakic, Milena Ugrin, Vesna Spasovski, Kristel Klaassen, Sonja Pavlovic, Maja Stojiljkovic
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Life
Subjects:
glycogen storage diseases
glycogen-selective autophagy
autophagy
apoptosis
modifier genes
autophagy-inducing drugs
Online Access:https://www.mdpi.com/2075-1729/12/9/1396

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