Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges
Non-healing wounds and skin losses constitute significant challenges for modern medicine and pharmacology. Conventional methods of wound treatment are effective in basic healthcare; however, they are insufficient in managing chronic wound and large skin defects, so novel, alternative methods of ther...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/7/3702 |
| _version_ | 1797212477375643648 |
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| author | Karolina Kondej Małgorzata Zawrzykraj Katarzyna Czerwiec Milena Deptuła Agata Tymińska Michał Pikuła |
| author_facet | Karolina Kondej Małgorzata Zawrzykraj Katarzyna Czerwiec Milena Deptuła Agata Tymińska Michał Pikuła |
| author_sort | Karolina Kondej |
| collection | DOAJ |
| description | Non-healing wounds and skin losses constitute significant challenges for modern medicine and pharmacology. Conventional methods of wound treatment are effective in basic healthcare; however, they are insufficient in managing chronic wound and large skin defects, so novel, alternative methods of therapy are sought. Among the potentially innovative procedures, the use of skin substitutes may be a promising therapeutic method. Skin substitutes are a heterogeneous group of materials that are used to heal and close wounds and temporarily or permanently fulfill the functions of the skin. Classification can be based on the structure or type (biological and synthetic). Simple constructs (class I) have been widely researched over the years, and can be used in burns and ulcers. More complex substitutes (class II and III) are still studied, but these may be utilized in patients with deep skin defects. In addition, 3D bioprinting is a rapidly developing method used to create advanced skin constructs and their appendages. The aforementioned therapies represent an opportunity for treating patients with diabetic foot ulcers or deep skin burns. Despite these significant developments, further clinical trials are needed to allow the use skin substitutes in the personalized treatment of chronic wounds. |
| first_indexed | 2024-04-24T10:43:00Z |
| format | Article |
| id | doaj.art-27661f1904d9465ba2ef7ad01ade1eec |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T10:43:00Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-27661f1904d9465ba2ef7ad01ade1eec2024-04-12T13:19:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01257370210.3390/ijms25073702Bioengineering Skin Substitutes for Wound Management—Perspectives and ChallengesKarolina Kondej0Małgorzata Zawrzykraj1Katarzyna Czerwiec2Milena Deptuła3Agata Tymińska4Michał Pikuła5Department of Plastic Surgery, Medical University of Gdansk, 80-214 Gdansk, PolandDepartment of Clinical Anatomy, Medical University of Gdansk, 80-211 Gdansk, PolandDepartment of Clinical Anatomy, Medical University of Gdansk, 80-211 Gdansk, PolandLaboratory of Tissue Engineering and Regenerative Medicine, Department of Embryology, Medical University of Gdansk, 80-211 Gdansk, PolandLaboratory of Tissue Engineering and Regenerative Medicine, Department of Embryology, Medical University of Gdansk, 80-211 Gdansk, PolandLaboratory of Tissue Engineering and Regenerative Medicine, Department of Embryology, Medical University of Gdansk, 80-211 Gdansk, PolandNon-healing wounds and skin losses constitute significant challenges for modern medicine and pharmacology. Conventional methods of wound treatment are effective in basic healthcare; however, they are insufficient in managing chronic wound and large skin defects, so novel, alternative methods of therapy are sought. Among the potentially innovative procedures, the use of skin substitutes may be a promising therapeutic method. Skin substitutes are a heterogeneous group of materials that are used to heal and close wounds and temporarily or permanently fulfill the functions of the skin. Classification can be based on the structure or type (biological and synthetic). Simple constructs (class I) have been widely researched over the years, and can be used in burns and ulcers. More complex substitutes (class II and III) are still studied, but these may be utilized in patients with deep skin defects. In addition, 3D bioprinting is a rapidly developing method used to create advanced skin constructs and their appendages. The aforementioned therapies represent an opportunity for treating patients with diabetic foot ulcers or deep skin burns. Despite these significant developments, further clinical trials are needed to allow the use skin substitutes in the personalized treatment of chronic wounds.https://www.mdpi.com/1422-0067/25/7/3702wound healingchronic woundshydrogelsscaffoldsregenerative medicinetissue engineering |
| spellingShingle | Karolina Kondej Małgorzata Zawrzykraj Katarzyna Czerwiec Milena Deptuła Agata Tymińska Michał Pikuła Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges International Journal of Molecular Sciences wound healing chronic wounds hydrogels scaffolds regenerative medicine tissue engineering |
| title | Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges |
| title_full | Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges |
| title_fullStr | Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges |
| title_full_unstemmed | Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges |
| title_short | Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges |
| title_sort | bioengineering skin substitutes for wound management perspectives and challenges |
| topic | wound healing chronic wounds hydrogels scaffolds regenerative medicine tissue engineering |
| url | https://www.mdpi.com/1422-0067/25/7/3702 |
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