Kidney Injury Biomarkers in Leptospirosis
ABSTRACT Leptospirosis is a zoonotic infection with a global distribution, though it has a greater impact on marginalized rural agricultural and urban communities in developing countries. Kidney injury, which can lead to severe and lethal infections, is the most frequent complication associated with...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2023-01-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822023000100200&lng=en&tlng=en |
| _version_ | 1797944885777530880 |
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| author | Pablo Uribe-Restrepo Claudia Munoz-Zanzi Piedad Agudelo-Flórez |
| author_facet | Pablo Uribe-Restrepo Claudia Munoz-Zanzi Piedad Agudelo-Flórez |
| author_sort | Pablo Uribe-Restrepo |
| collection | DOAJ |
| description | ABSTRACT Leptospirosis is a zoonotic infection with a global distribution, though it has a greater impact on marginalized rural agricultural and urban communities in developing countries. Kidney injury, which can lead to severe and lethal infections, is the most frequent complication associated with leptospirosis. Novel biomarkers are being studied as tools for assessing kidney injury in different pathological processes to improve early detection. This review aimed to gather information on the use of novel kidney biomarkers for human leptospirosis. A search of the literature was carried out in September 2021 using the parameters “((kidney) OR (renal) OR (chronic kidney disease) OR (acute kidney injury)) AND ((biomarker) OR (marker)) AND ((Leptospira) OR (leptospirosis))”. The review identified 11 original studies that evaluated the performance of 15 kidney biomarkers related to leptospirosis. Assessment of the evidence for biomarker utility was limited because of the small number of studies and sample sizes. Although some biomarkers were associated with kidney disease, no specific biomarker appeared to be ready for clinical practice, and more research in this field is necessary. |
| first_indexed | 2024-04-10T20:45:35Z |
| format | Article |
| id | doaj.art-2767493b8a7f4439a7ef419dcf9d0348 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-10T20:45:35Z |
| publishDate | 2023-01-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-2767493b8a7f4439a7ef419dcf9d03482023-01-24T07:35:49ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492023-01-015610.1590/0037-8682-0260-2022Kidney Injury Biomarkers in LeptospirosisPablo Uribe-Restrepohttps://orcid.org/0000-0001-8897-5950Claudia Munoz-Zanzihttps://orcid.org/0000-0001-9317-7152Piedad Agudelo-Flórezhttps://orcid.org/0000-0002-0002-776XABSTRACT Leptospirosis is a zoonotic infection with a global distribution, though it has a greater impact on marginalized rural agricultural and urban communities in developing countries. Kidney injury, which can lead to severe and lethal infections, is the most frequent complication associated with leptospirosis. Novel biomarkers are being studied as tools for assessing kidney injury in different pathological processes to improve early detection. This review aimed to gather information on the use of novel kidney biomarkers for human leptospirosis. A search of the literature was carried out in September 2021 using the parameters “((kidney) OR (renal) OR (chronic kidney disease) OR (acute kidney injury)) AND ((biomarker) OR (marker)) AND ((Leptospira) OR (leptospirosis))”. The review identified 11 original studies that evaluated the performance of 15 kidney biomarkers related to leptospirosis. Assessment of the evidence for biomarker utility was limited because of the small number of studies and sample sizes. Although some biomarkers were associated with kidney disease, no specific biomarker appeared to be ready for clinical practice, and more research in this field is necessary.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822023000100200&lng=en&tlng=enLeptospiraLeptospirosisBiomarkersAcute kidney injuryKidney disease |
| spellingShingle | Pablo Uribe-Restrepo Claudia Munoz-Zanzi Piedad Agudelo-Flórez Kidney Injury Biomarkers in Leptospirosis Revista da Sociedade Brasileira de Medicina Tropical Leptospira Leptospirosis Biomarkers Acute kidney injury Kidney disease |
| title | Kidney Injury Biomarkers in Leptospirosis |
| title_full | Kidney Injury Biomarkers in Leptospirosis |
| title_fullStr | Kidney Injury Biomarkers in Leptospirosis |
| title_full_unstemmed | Kidney Injury Biomarkers in Leptospirosis |
| title_short | Kidney Injury Biomarkers in Leptospirosis |
| title_sort | kidney injury biomarkers in leptospirosis |
| topic | Leptospira Leptospirosis Biomarkers Acute kidney injury Kidney disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822023000100200&lng=en&tlng=en |
| work_keys_str_mv | AT pablouriberestrepo kidneyinjurybiomarkersinleptospirosis AT claudiamunozzanzi kidneyinjurybiomarkersinleptospirosis AT piedadagudeloflorez kidneyinjurybiomarkersinleptospirosis |