MAFB and MAF Transcription Factors as Macrophage Checkpoints for COVID-19 Severity

MAFB and MAF Transcription Factors as Macrophage Checkpoints for COVID-19 Severity

Defective IFN production and exacerbated inflammatory and pro-fibrotic responses are hallmarks of SARS-CoV-2 infection in severe COVID-19. Based on these hallmarks, and considering the pivotal role of macrophages in COVID-19 pathogenesis, we hypothesize that the transcription factors MAFB and MAF cr...

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Bibliographic Details
Main Authors: Miguel A. Vega, Miriam Simón-Fuentes, Arturo González de la Aleja, Concha Nieto, María Colmenares, Cristina Herrero, Ángeles Domínguez-Soto, Ángel L. Corbí
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
macrophage
innate immunity
COVID-19
MAFB
MAF
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.603507/full

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