Fabricating hierarchical ZSM-5 to induct long chain antioxidant coenzyme Q10 for biomedical application
The study investigates the hydrophobic antioxidant Coenzyme Q10 (CoQ10) adsorption over industrially relevant hierarchical ZSM-5 for potential therapeutic applications. The designing of hierarchical nanocomposites was optimized with two different NaOH/CTAB ratios (0.18 and 0.62) over ZSM-5 (SiO2/Al2...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-05-01
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| Series: | Journal of Saudi Chemical Society |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610318301042 |
| _version_ | 1819213275886256128 |
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| author | Vijaya Ravinayagam B. Rabindran Jermy |
| author_facet | Vijaya Ravinayagam B. Rabindran Jermy |
| author_sort | Vijaya Ravinayagam |
| collection | DOAJ |
| description | The study investigates the hydrophobic antioxidant Coenzyme Q10 (CoQ10) adsorption over industrially relevant hierarchical ZSM-5 for potential therapeutic applications. The designing of hierarchical nanocomposites was optimized with two different NaOH/CTAB ratios (0.18 and 0.62) over ZSM-5 (SiO2/Al2O3 = 22–27) of different crystal sizes (0.5 µm, 2.0 µm and 3.0 µm) and different SiO2/Al2O3 ratios (23, 80, 280 and 1500) through top-down approach. Hydrothermal stability of samples was studied using 100% water steam at 700 °C and 750 °C for 2 h, respectively. Reassembling nano ZSM-5 into hierarchical composite was found to exhibit ordered/disordered hexagonal mesophase depending on alkaline treated ZSM-5 crystal sizes and silica to alumina ratios. The phase changes were analyzed using different textural characterizations such as X-ray diffraction, BET surface area, ammonia desorption technique, 27Al MAS NMR, thermogravimetric analysis and transmission electron microscope. 21 different nanoformulations were screened for CoQ10 adsorption and subsequently selected samples were applied for curcumin and ascorbic acid adsorption. Hierarchical ZSM-5 with SiO2/Al2O3 ratio 80 (ZSM-5-80 (0.62)) was found to be steam stable and optimum with highest Q10 adsorption (55%). The adsorption influence over different crystal size and silica to alumina ratios, clearly showed the dependency over synergistic action of textural characteristics such as external surface area, pore volume, and weak acidity. The structured nanosupports with pore sizes between 3 and 4.0 nm were found to exhibit highest CoQ10 adsorption. Keywords: Hierarchical, ZSM-5, Antioxidant, Q10 coenzyme, Biomedical application |
| first_indexed | 2024-12-23T06:56:17Z |
| format | Article |
| id | doaj.art-2768102f4a194a19be4f63656fa9d089 |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-12-23T06:56:17Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-2768102f4a194a19be4f63656fa9d0892022-12-21T17:56:19ZengElsevierJournal of Saudi Chemical Society1319-61032019-05-01234461476Fabricating hierarchical ZSM-5 to induct long chain antioxidant coenzyme Q10 for biomedical applicationVijaya Ravinayagam0B. Rabindran Jermy1Deanship of Scientific Research & Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University (IAU), Dammam 31441, Saudi ArabiaDepartment of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University (IAU), Dammam 31441, Saudi Arabia; Corresponding author.The study investigates the hydrophobic antioxidant Coenzyme Q10 (CoQ10) adsorption over industrially relevant hierarchical ZSM-5 for potential therapeutic applications. The designing of hierarchical nanocomposites was optimized with two different NaOH/CTAB ratios (0.18 and 0.62) over ZSM-5 (SiO2/Al2O3 = 22–27) of different crystal sizes (0.5 µm, 2.0 µm and 3.0 µm) and different SiO2/Al2O3 ratios (23, 80, 280 and 1500) through top-down approach. Hydrothermal stability of samples was studied using 100% water steam at 700 °C and 750 °C for 2 h, respectively. Reassembling nano ZSM-5 into hierarchical composite was found to exhibit ordered/disordered hexagonal mesophase depending on alkaline treated ZSM-5 crystal sizes and silica to alumina ratios. The phase changes were analyzed using different textural characterizations such as X-ray diffraction, BET surface area, ammonia desorption technique, 27Al MAS NMR, thermogravimetric analysis and transmission electron microscope. 21 different nanoformulations were screened for CoQ10 adsorption and subsequently selected samples were applied for curcumin and ascorbic acid adsorption. Hierarchical ZSM-5 with SiO2/Al2O3 ratio 80 (ZSM-5-80 (0.62)) was found to be steam stable and optimum with highest Q10 adsorption (55%). The adsorption influence over different crystal size and silica to alumina ratios, clearly showed the dependency over synergistic action of textural characteristics such as external surface area, pore volume, and weak acidity. The structured nanosupports with pore sizes between 3 and 4.0 nm were found to exhibit highest CoQ10 adsorption. Keywords: Hierarchical, ZSM-5, Antioxidant, Q10 coenzyme, Biomedical applicationhttp://www.sciencedirect.com/science/article/pii/S1319610318301042 |
| spellingShingle | Vijaya Ravinayagam B. Rabindran Jermy Fabricating hierarchical ZSM-5 to induct long chain antioxidant coenzyme Q10 for biomedical application Journal of Saudi Chemical Society |
| title | Fabricating hierarchical ZSM-5 to induct long chain antioxidant coenzyme Q10 for biomedical application |
| title_full | Fabricating hierarchical ZSM-5 to induct long chain antioxidant coenzyme Q10 for biomedical application |
| title_fullStr | Fabricating hierarchical ZSM-5 to induct long chain antioxidant coenzyme Q10 for biomedical application |
| title_full_unstemmed | Fabricating hierarchical ZSM-5 to induct long chain antioxidant coenzyme Q10 for biomedical application |
| title_short | Fabricating hierarchical ZSM-5 to induct long chain antioxidant coenzyme Q10 for biomedical application |
| title_sort | fabricating hierarchical zsm 5 to induct long chain antioxidant coenzyme q10 for biomedical application |
| url | http://www.sciencedirect.com/science/article/pii/S1319610318301042 |
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