Advances in biomarkers of cerebral small vessel disease
Cerebral small vessel disease (CSVD) refers to a type of syndrome caused by lesions in perforating arteries, small veins, small arteries, or capillaries, resulting in clinical, imaging, or pathological alterations. The occurrence and development of CSVD are related to various cerebrovascular risk fa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-12-01
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| Series: | Journal of Neurorestoratology |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.26599/JNR.2019.9040021 |
| _version_ | 1797706034240815104 |
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| author | Xue Peng Jianhua Zhao Junli Liu Shaomin Li |
| author_facet | Xue Peng Jianhua Zhao Junli Liu Shaomin Li |
| author_sort | Xue Peng |
| collection | DOAJ |
| description | Cerebral small vessel disease (CSVD) refers to a type of syndrome caused by lesions in perforating arteries, small veins, small arteries, or capillaries, resulting in clinical, imaging, or pathological alterations. The occurrence and development of CSVD are related to various cerebrovascular risk factors, such as metabolism and genetic factors. CSVD is diagnosed based on brain imaging biomarkers; however, biomarkers capable of predicting and diagnosing CSVD early in its progression have not been found. Exploring biomarkers closely related to disease progression is of great significance for early diagnosis, prognosis, prevention, and treatment of CSVD. This article examines the research progress of CSVD biomarkers, from inflammatory biomarkers, coagulation and fibrinolysis markers, biomarkers of endothelial dysfunction, biomarkers related to cerebrospinal fluid, and gene markers. |
| first_indexed | 2024-03-12T05:45:10Z |
| format | Article |
| id | doaj.art-276831fcc3db4b6fb528f46e1785d2a9 |
| institution | Directory Open Access Journal |
| issn | 2324-2426 |
| language | English |
| last_indexed | 2024-03-12T05:45:10Z |
| publishDate | 2019-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Neurorestoratology |
| spelling | doaj.art-276831fcc3db4b6fb528f46e1785d2a92023-09-03T05:38:08ZengElsevierJournal of Neurorestoratology2324-24262019-12-017417118310.26599/JNR.2019.9040021Advances in biomarkers of cerebral small vessel diseaseXue Peng0Jianhua Zhao1Junli Liu2Shaomin Li3<institution>First Affiliated Hospital of Xinxiang Medical University</institution>, <city>Xinxiang</city> <postal-code>453100</postal-code>, <state>Henan</state>, <country>China</country><institution>First Affiliated Hospital of Xinxiang Medical University</institution>, <city>Xinxiang</city> <postal-code>453100</postal-code>, <state>Henan</state>, <country>China</country><institution>First Affiliated Hospital of Xinxiang Medical University</institution>, <city>Xinxiang</city> <postal-code>453100</postal-code>, <state>Henan</state>, <country>China</country><institution content-type="dept">Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital</institution>, <institution>Harvard Medical School</institution>, <city>Boston</city> <postal-code>02115</postal-code>, <state>Massachusetts</state>, <country>United States</country>Cerebral small vessel disease (CSVD) refers to a type of syndrome caused by lesions in perforating arteries, small veins, small arteries, or capillaries, resulting in clinical, imaging, or pathological alterations. The occurrence and development of CSVD are related to various cerebrovascular risk factors, such as metabolism and genetic factors. CSVD is diagnosed based on brain imaging biomarkers; however, biomarkers capable of predicting and diagnosing CSVD early in its progression have not been found. Exploring biomarkers closely related to disease progression is of great significance for early diagnosis, prognosis, prevention, and treatment of CSVD. This article examines the research progress of CSVD biomarkers, from inflammatory biomarkers, coagulation and fibrinolysis markers, biomarkers of endothelial dysfunction, biomarkers related to cerebrospinal fluid, and gene markers.https://www.sciopen.com/article/10.26599/JNR.2019.9040021cerebral small vessel diseasebiomarkersrisk factors |
| spellingShingle | Xue Peng Jianhua Zhao Junli Liu Shaomin Li Advances in biomarkers of cerebral small vessel disease Journal of Neurorestoratology cerebral small vessel disease biomarkers risk factors |
| title | Advances in biomarkers of cerebral small vessel disease |
| title_full | Advances in biomarkers of cerebral small vessel disease |
| title_fullStr | Advances in biomarkers of cerebral small vessel disease |
| title_full_unstemmed | Advances in biomarkers of cerebral small vessel disease |
| title_short | Advances in biomarkers of cerebral small vessel disease |
| title_sort | advances in biomarkers of cerebral small vessel disease |
| topic | cerebral small vessel disease biomarkers risk factors |
| url | https://www.sciopen.com/article/10.26599/JNR.2019.9040021 |
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