Variations of Thiol–Disulfide Homeostasis Parameters after Treatment with H1-Antihistamines in Patients with Chronic Spontaneous Urticaria
Background. The pathogenesis of chronic spontaneous urticaria involves metabolic, immunological, and psychological factors. The thiol–disulfide exchange reactions could be a mechanism to counteract oxidative stress in patients with chronic spontaneous urticaria. Objective: The assessment of thiol–di...
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MDPI AG
2021-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/13/2980 |
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| author | Clara Matei Simona Roxana Georgescu Ilinca Nicolae Corina Daniela Ene Cristina Iulia Mitran Madalina Irina Mitran Mircea Tampa |
| author_facet | Clara Matei Simona Roxana Georgescu Ilinca Nicolae Corina Daniela Ene Cristina Iulia Mitran Madalina Irina Mitran Mircea Tampa |
| author_sort | Clara Matei |
| collection | DOAJ |
| description | Background. The pathogenesis of chronic spontaneous urticaria involves metabolic, immunological, and psychological factors. The thiol–disulfide exchange reactions could be a mechanism to counteract oxidative stress in patients with chronic spontaneous urticaria. Objective: The assessment of thiol–disulfide homeostasis parameters (TDHPs) according to disease severity and the influence of H1-antihistamine therapy in patients with chronic spontaneous urticaria. Material and method. We have included 30 patients with chronic spontaneous urticaria in the study and we have determined the levels of native thiol, total thiol, disulfides as well as the disulfide/native thiol ratio, disulfide/total thiol ratio and the native thiol/total thiol ratio, before and after therapy with H1-antihistamines. Results. The results of the study showed altered levels of TDHPs and their normalization after treatment with H1-antihistamines in patients with chronic spontaneous urticaria. We determined a statistically significant increase in the serum levels of total thiol, native thiol, and native thiol/total thiol ratio and a significant reduction in the levels of disulfides, disulfide/native thiol ratio and disulfide/total thiol ratio after treatment with H1-antihistamines. The normalization of the serum levels of TDHPs has been associated with the relief of symptoms and reduction or resolution of pruritus and urticarial plaques. Conclusion. These results suggest the involvement of thiol–disulfide homeostasis in the defense against the harmful effects of reactive oxygen species in patients with chronic spontaneous urticaria and the potential role of TDHPs in monitoring H1-antihistamine therapy. To the best of our knowledge, this is the first study investigating TDHPs in patients with chronic spontaneous urticaria before and after treatment. |
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| format | Article |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:51:34Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-276974f97b884e039b619040d2d7a9ca2023-11-22T02:43:07ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-011013298010.3390/jcm10132980Variations of Thiol–Disulfide Homeostasis Parameters after Treatment with H1-Antihistamines in Patients with Chronic Spontaneous UrticariaClara Matei0Simona Roxana Georgescu1Ilinca Nicolae2Corina Daniela Ene3Cristina Iulia Mitran4Madalina Irina Mitran5Mircea Tampa6Department of Dermatology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Dermatology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Dermatology, Victor Babes Clinical Hospital for Infectious Diseases, 030303 Bucharest, RomaniaDepartment of Nephrology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Microbiology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Microbiology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Dermatology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaBackground. The pathogenesis of chronic spontaneous urticaria involves metabolic, immunological, and psychological factors. The thiol–disulfide exchange reactions could be a mechanism to counteract oxidative stress in patients with chronic spontaneous urticaria. Objective: The assessment of thiol–disulfide homeostasis parameters (TDHPs) according to disease severity and the influence of H1-antihistamine therapy in patients with chronic spontaneous urticaria. Material and method. We have included 30 patients with chronic spontaneous urticaria in the study and we have determined the levels of native thiol, total thiol, disulfides as well as the disulfide/native thiol ratio, disulfide/total thiol ratio and the native thiol/total thiol ratio, before and after therapy with H1-antihistamines. Results. The results of the study showed altered levels of TDHPs and their normalization after treatment with H1-antihistamines in patients with chronic spontaneous urticaria. We determined a statistically significant increase in the serum levels of total thiol, native thiol, and native thiol/total thiol ratio and a significant reduction in the levels of disulfides, disulfide/native thiol ratio and disulfide/total thiol ratio after treatment with H1-antihistamines. The normalization of the serum levels of TDHPs has been associated with the relief of symptoms and reduction or resolution of pruritus and urticarial plaques. Conclusion. These results suggest the involvement of thiol–disulfide homeostasis in the defense against the harmful effects of reactive oxygen species in patients with chronic spontaneous urticaria and the potential role of TDHPs in monitoring H1-antihistamine therapy. To the best of our knowledge, this is the first study investigating TDHPs in patients with chronic spontaneous urticaria before and after treatment.https://www.mdpi.com/2077-0383/10/13/2980thioldisulfideurticariaH1-antihistamines |
| spellingShingle | Clara Matei Simona Roxana Georgescu Ilinca Nicolae Corina Daniela Ene Cristina Iulia Mitran Madalina Irina Mitran Mircea Tampa Variations of Thiol–Disulfide Homeostasis Parameters after Treatment with H1-Antihistamines in Patients with Chronic Spontaneous Urticaria Journal of Clinical Medicine thiol disulfide urticaria H1-antihistamines |
| title | Variations of Thiol–Disulfide Homeostasis Parameters after Treatment with H1-Antihistamines in Patients with Chronic Spontaneous Urticaria |
| title_full | Variations of Thiol–Disulfide Homeostasis Parameters after Treatment with H1-Antihistamines in Patients with Chronic Spontaneous Urticaria |
| title_fullStr | Variations of Thiol–Disulfide Homeostasis Parameters after Treatment with H1-Antihistamines in Patients with Chronic Spontaneous Urticaria |
| title_full_unstemmed | Variations of Thiol–Disulfide Homeostasis Parameters after Treatment with H1-Antihistamines in Patients with Chronic Spontaneous Urticaria |
| title_short | Variations of Thiol–Disulfide Homeostasis Parameters after Treatment with H1-Antihistamines in Patients with Chronic Spontaneous Urticaria |
| title_sort | variations of thiol disulfide homeostasis parameters after treatment with h1 antihistamines in patients with chronic spontaneous urticaria |
| topic | thiol disulfide urticaria H1-antihistamines |
| url | https://www.mdpi.com/2077-0383/10/13/2980 |
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