Impact of Early Childhood Malnutrition on Adult Brain Function: An Evoked-Related Potentials Study
More than 200 million children under the age of 5 years are affected by malnutrition worldwide according to the World Health Organization. The Barbados Nutrition Study (BNS) is a 55-year longitudinal study on a Barbadian cohort with histories of moderate to severe protein-energy malnutrition (PEM) l...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.884251/full |
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| author | Kassandra Roger Phetsamone Vannasing Julie Tremblay Maria L. Bringas Vega Cyralene P. Bryce Arielle G. Rabinowitz Pedro A. Valdés-Sosa Janina R. Galler Anne Gallagher |
| author_facet | Kassandra Roger Phetsamone Vannasing Julie Tremblay Maria L. Bringas Vega Cyralene P. Bryce Arielle G. Rabinowitz Pedro A. Valdés-Sosa Janina R. Galler Anne Gallagher |
| author_sort | Kassandra Roger |
| collection | DOAJ |
| description | More than 200 million children under the age of 5 years are affected by malnutrition worldwide according to the World Health Organization. The Barbados Nutrition Study (BNS) is a 55-year longitudinal study on a Barbadian cohort with histories of moderate to severe protein-energy malnutrition (PEM) limited to the first year of life and a healthy comparison group. Using quantitative electroencephalography (EEG), differences in brain function during childhood (lower alpha1 activity and higher theta, alpha2 and beta activity) have previously been highlighted between participants who suffered from early PEM and controls. In order to determine whether similar differences persisted into adulthood, our current study used recordings obtained during a Go-No-Go task in a subsample of the original BNS cohort [population size (N) = 53] at ages 45–51 years. We found that previously malnourished adults [sample size (n) = 24] had a higher rate of omission errors on the task relative to controls (n = 29). Evoked-Related Potentials (ERP) were significantly different in participants with histories of early PEM, who presented with lower N2 amplitudes. These findings are typically associated with impaired conflict monitoring and/or attention deficits and may therefore be linked to the attentional and executive function deficits that have been previously reported in this cohort in childhood and again in middle adulthood. |
| first_indexed | 2024-04-12T12:58:48Z |
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| id | doaj.art-276b9bc7d1a44d478d3abba4c908a00f |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-12T12:58:48Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-276b9bc7d1a44d478d3abba4c908a00f2022-12-22T03:32:14ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-07-011610.3389/fnhum.2022.884251884251Impact of Early Childhood Malnutrition on Adult Brain Function: An Evoked-Related Potentials StudyKassandra Roger0Phetsamone Vannasing1Julie Tremblay2Maria L. Bringas Vega3Cyralene P. Bryce4Arielle G. Rabinowitz5Pedro A. Valdés-Sosa6Janina R. Galler7Anne Gallagher8LION Lab, Sainte-Justine University Hospital Research Center, University of Montreal, Montreal, QC, CanadaLION Lab, Sainte-Justine University Hospital Research Center, University of Montreal, Montreal, QC, CanadaLION Lab, Sainte-Justine University Hospital Research Center, University of Montreal, Montreal, QC, CanadaMOE Key Lab for Neuroinformation, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, ChinaBarbados Nutrition Study, Bridgetown, BarbadosDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, CanadaMOE Key Lab for Neuroinformation, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, ChinaDivision of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Boston, MA, United StatesLION Lab, Sainte-Justine University Hospital Research Center, University of Montreal, Montreal, QC, CanadaMore than 200 million children under the age of 5 years are affected by malnutrition worldwide according to the World Health Organization. The Barbados Nutrition Study (BNS) is a 55-year longitudinal study on a Barbadian cohort with histories of moderate to severe protein-energy malnutrition (PEM) limited to the first year of life and a healthy comparison group. Using quantitative electroencephalography (EEG), differences in brain function during childhood (lower alpha1 activity and higher theta, alpha2 and beta activity) have previously been highlighted between participants who suffered from early PEM and controls. In order to determine whether similar differences persisted into adulthood, our current study used recordings obtained during a Go-No-Go task in a subsample of the original BNS cohort [population size (N) = 53] at ages 45–51 years. We found that previously malnourished adults [sample size (n) = 24] had a higher rate of omission errors on the task relative to controls (n = 29). Evoked-Related Potentials (ERP) were significantly different in participants with histories of early PEM, who presented with lower N2 amplitudes. These findings are typically associated with impaired conflict monitoring and/or attention deficits and may therefore be linked to the attentional and executive function deficits that have been previously reported in this cohort in childhood and again in middle adulthood.https://www.frontiersin.org/articles/10.3389/fnhum.2022.884251/fullEEGGo-No-GoERPinhibitionattentionprotein-energy malnutrition (PEM) |
| spellingShingle | Kassandra Roger Phetsamone Vannasing Julie Tremblay Maria L. Bringas Vega Cyralene P. Bryce Arielle G. Rabinowitz Pedro A. Valdés-Sosa Janina R. Galler Anne Gallagher Impact of Early Childhood Malnutrition on Adult Brain Function: An Evoked-Related Potentials Study Frontiers in Human Neuroscience EEG Go-No-Go ERP inhibition attention protein-energy malnutrition (PEM) |
| title | Impact of Early Childhood Malnutrition on Adult Brain Function: An Evoked-Related Potentials Study |
| title_full | Impact of Early Childhood Malnutrition on Adult Brain Function: An Evoked-Related Potentials Study |
| title_fullStr | Impact of Early Childhood Malnutrition on Adult Brain Function: An Evoked-Related Potentials Study |
| title_full_unstemmed | Impact of Early Childhood Malnutrition on Adult Brain Function: An Evoked-Related Potentials Study |
| title_short | Impact of Early Childhood Malnutrition on Adult Brain Function: An Evoked-Related Potentials Study |
| title_sort | impact of early childhood malnutrition on adult brain function an evoked related potentials study |
| topic | EEG Go-No-Go ERP inhibition attention protein-energy malnutrition (PEM) |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.884251/full |
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