A Three-Monoclonal Antibody Combination Potently Neutralizes BoNT/G Toxin in Mice

A Three-Monoclonal Antibody Combination Potently Neutralizes BoNT/G Toxin in Mice

Equine-derived antitoxin (BAT<sup>®</sup>) is the only treatment for botulism from botulinum neurotoxin serotype G (BoNT/G). BAT<sup>®</sup> is a foreign protein with potentially severe adverse effects and is not renewable. To develop a safe, more potent, and renewable antito...

Full description

Bibliographic Details
Main Authors:	Yongfeng Fan, Jianlong Lou, Christina C. Tam, Weihua Wen, Fraser Conrad, Priscila Leal da Silva Alves, Luisa W. Cheng, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, James D. Marks
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Series:	Toxins
Subjects:	botulinum neurotoxin oligoclonal antibodies serotype G botulism recombinant antibodies antibody engineering mouse neutralization assay
Online Access:	https://www.mdpi.com/2072-6651/15/5/316

Similar Items

A Four-Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotypes C and D
by: Consuelo Garcia-Rodriguez, et al.
Published: (2021-09-01)

A Monoclonal Antibody Combination against both Serotypes A and B Botulinum Toxin Prevents Inhalational Botulism in a Guinea Pig Model
by: Doris M. Snow, et al.
Published: (2021-01-01)

Neutralizing Concentrations of Anti-Botulinum Toxin Antibodies Positively Correlate with Mouse Neutralization Assay Results in a Guinea Pig Model
by: Milan T. Tomic, et al.
Published: (2021-09-01)

Exploring the genetic background of the botulism neurotoxin BoNT/B2 in Spain
by: Sylvia Valdezate, et al.
Published: (2023-10-01)

Production of monoclonal antibodies against botulinum neurotoxin in Nicotiana benthamiana
by: Kornchanok Sangprasat, et al.
Published: (2024-12-01)

BoNT/A in the Urinary Bladder—More to the Story than Silencing of Cholinergic Nerves
by: Hodan Ibrahim, et al.
Published: (2022-01-01)

Navigating the Complexities Involving the Identification of Botulinum Neurotoxins (BoNTs) and the Taxonomy of BoNT-Producing Clostridia
by: Theresa J. Smith, et al.
Published: (2023-09-01)

Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function
by: Jacqueline M. Tremblay, et al.
Published: (2020-09-01)

Novel Botulinum Neurotoxins: Exploring Underneath the Iceberg Tip
by: Domenico Azarnia Tehran, et al.
Published: (2018-05-01)

Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells
by: Kwok-Ho Lam, et al.
Published: (2020-09-01)

Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine
by: Lauretta Turin, et al.
Published: (2023-07-01)

Botulinum Neurotoxin BoNT-A in the Management of Hypertrophic Scars and Keloids: A Comprehensive Review
by: Ramadan S. Hussein
Published: (2024-03-01)

A novel RRGW derived peptide is a promising inhibitor of BoNT/A
by: Wantong Ma, et al.
Published: (2023-12-01)

Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B
by: Takuhiro Matsumura, et al.
Published: (2020-05-01)

Botulism in Spain: Epidemiology and Outcomes of Antitoxin Treatment, 1997–2019
by: Marina Peñuelas, et al.
Published: (2022-12-01)

Expression, Purification and evaluation of the Immunogenicity of RecombinantC-terminus of the Receptor-Binding Domain of Neurotoxin Botulinum Protein Type B (BoNT/B-HcC)
by: Hossein Samiei Abianeh, et al.
Published: (2023-08-01)

New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A
by: Marina Vladimirovna Silkina, et al.
Published: (2024-07-01)

Characterization of Serotype CD Mosaic Botulinum Neurotoxin in Comparison with Serotype C and A
by: Shin-Ichiro Miyashita, et al.
Published: (2023-02-01)

A Thermostable Dissolving Microneedle Vaccine with Recombinant Protein of Botulinum Neurotoxin Serotype A
by: Baohua Zhao, et al.
Published: (2022-12-01)

Single-Domain Antibody Multimers for Detection of Botulinum Neurotoxin Serotypes C, D, and Their Mosaics in Endopep-MS
by: Michiel M. Harmsen, et al.
Published: (2023-09-01)

Applications, impacts and consequences of botulinum toxin usage in medicine
by: Weronika Kiełt, et al.
Published: (2024-10-01)

Human Botulism in France, 1875–2016
by: Christine Rasetti-Escargueil, et al.
Published: (2020-05-01)

Botulinum Neurotoxins as Two-Faced Janus Proteins
by: Silvia Chimienti, et al.
Published: (2025-02-01)

Botulinum toxin and botulism. A clinical case.
by: E. S. Korovkina, et al.
Published: (2024-09-01)

Botulism in Brazil, 2000-2008: epidemiology, clinical findings and laboratorial diagnosis Botulismo no Brasil, 2000-2008: epidemiologia, achados clínicos e diagnóstico laboratorial
by: Ruth Estela Gravato Rowlands, et al.
Published: (2010-08-01)

Toxemia in Human Naturally Acquired Botulism
by: Christine Rasetti-Escargueil, et al.
Published: (2020-11-01)

Development of Effective Medical Countermeasures Against the Main Biowarfare Agents: The Importance of Antibodies
by: Arnaud Avril, et al.
Published: (2024-12-01)

Detection of nontoxic BoNT/A levels in post-facial Botox injection breastmilk
by: Helene Gu, et al.
Published: (2025-01-01)

Neurotropic Effect of Botulinum Toxin and the Potential of Specific Serum Therapy in Botulism (Review)
by: E. M. Eliseeva, et al.
Published: (2024-10-01)

Multimodal therapy and use of adjunctive therapies to BoNT-A in spasticity management: defining terminology to help enhance spasticity treatment
by: Rajiv Reebye, et al.
Published: (2024-08-01)

Emergence of Novel Type C Botulism Strain in Household Outbreak, Japan
by: Rika Maeda, et al.
Published: (2023-10-01)

International Proficiency Test Targeting a Large Panel of Botulinum Neurotoxin Sero- and Subtypes in Different Matrices
by: Christine Rasetti-Escargueil, et al.
Published: (2024-11-01)

Novel platform for engineering stable and effective vaccines against botulinum neurotoxins A, B and E
by: Yang Liu, et al.
Published: (2024-09-01)

Laboratory investigation of the first infant botulism case caused by type E botulinum neurotoxin producing Clostridium butyricum in China
by: Yinping DONG, et al.
Published: (2020-09-01)

Preclinical Evidence for the Role of Botulinum Neurotoxin A (BoNT/A) in the Treatment of Peripheral Nerve Injury
by: Michael Adler, et al.
Published: (2022-04-01)

Continuous Treatment with IncobotulinumtoxinA Despite Presence of BoNT/A Neutralizing Antibodies: Immunological Hypothesis and a Case Report
by: Michael Uwe Martin, et al.
Published: (2024-10-01)

Addressing the Real-World Challenges of Immunoresistance to Botulinum Neurotoxin A in Aesthetic Practice: Insights and Recommendations from a Panel Discussion in Hong Kong
by: Wilson W. S. Ho, et al.
Published: (2023-07-01)

Selection of Candidate Monoclonal Antibodies for Therapy of Botulinum Toxin Type A Intoxications
by: Natalia A. Zeninskaya, et al.
Published: (2024-06-01)

Iatrogenic botulism after intragastric botulinum neurotoxin injections – a major outbreak
by: Tsepo Goerttler, et al.
Published: (2024-10-01)

Recent Developments in Botulinum Neurotoxins Detection
by: Christine Rasetti-Escargueil, et al.
Published: (2022-05-01)