Dickkopf-1 (DKK1) blockade mitigates osteogenesis imperfecta (OI) related bone disease

Dickkopf-1 (DKK1) blockade mitigates osteogenesis imperfecta (OI) related bone disease

Abstract Background The current treatment of osteogenesis imperfecta (OI) is imperfect. Our study thus delves into the potential of using Dickkopf-1 antisense (DKK1-AS) to treat OI. Methods We analysed serum DKK1 levels and their correlation with lumbar spine and hip T-scores in OI patients. Compara...

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Bibliographic Details
Main Authors: Jih-Yang Ko, Feng-Sheng Wang, Wei-Shiung Lian, Fu-Shine Yang, Jeng-Wei Chen, Po-Hua Huang, Chin-Yi Liao, Shu-Jui Kuo
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Molecular Medicine
Subjects:
Osteogenesis imperfecta (OI)
Dickkopf-1 (DKK1)
β-Catenin
T-cell factor 4 (TCF4)
Wnt3a
Osteoprotegerin (OPG)
Online Access:https://doi.org/10.1186/s10020-024-00838-3

Internet

https://doi.org/10.1186/s10020-024-00838-3

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