Formulation of enteric coated microspheres containing pantoprazole
Pantoprazole is a first-line proton pump inhibitor drug for the treatment of gastric acid secretion disorders that is known to have minimal side effects and drug interactions. To improve its stability in gastric acid, delayedrelease microspheres containing pantoprazole was prepared by emulsificatio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Vietnam Ministry of Science and Technology
2022-03-01
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| Series: | Vietnam Journal of Science, Technology and Engineering |
| Subjects: | |
| Online Access: | https://vietnamscience.vjst.vn/index.php/vjste/article/view/67 |
| _version_ | 1828047880768716800 |
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| author | Xuan Truong Le Hue Minh Nguyen Ngoc Quynh Le Thi Thu Loan Trinh Van Thanh Tran |
| author_facet | Xuan Truong Le Hue Minh Nguyen Ngoc Quynh Le Thi Thu Loan Trinh Van Thanh Tran |
| author_sort | Xuan Truong Le |
| collection | DOAJ |
| description |
Pantoprazole is a first-line proton pump inhibitor drug for the treatment of gastric acid secretion disorders that is known to have minimal side effects and drug interactions. To improve its stability in gastric acid, delayedrelease microspheres containing pantoprazole was prepared by emulsification-solvent evaporation using a polymer-containing mixture of hydroxypropyl cellulose (HPC) and ethyl cellulose (EC), which was then coated by alginate and Eudragit L100. The morphological characteristics of the microspheres were examined by SEM, the particle size distribution inferred by laser diffraction, and the physical state of drug substance was measured by Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and in vitro drug release. The three formulations of microspheres chosen for this study had an average size of 100 µm. The dissolution profile showed less than 10% of the drug was released after 120 min in 0.1-M HCl and more than 75% of drug was released after 45 min in a phosphate buffer with a pH of 6.8.
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| first_indexed | 2024-04-10T18:48:59Z |
| format | Article |
| id | doaj.art-276daa18a06e4daea9fb241ae95811e9 |
| institution | Directory Open Access Journal |
| issn | 2525-2461 2615-9937 |
| language | English |
| last_indexed | 2024-04-10T18:48:59Z |
| publishDate | 2022-03-01 |
| publisher | Vietnam Ministry of Science and Technology |
| record_format | Article |
| series | Vietnam Journal of Science, Technology and Engineering |
| spelling | doaj.art-276daa18a06e4daea9fb241ae95811e92023-02-01T08:17:04ZengVietnam Ministry of Science and TechnologyVietnam Journal of Science, Technology and Engineering2525-24612615-99372022-03-0163310.31276/VJSTE.63(3).56-62Formulation of enteric coated microspheres containing pantoprazoleXuan Truong Le0Hue Minh Nguyen1Ngoc Quynh Le2Thi Thu Loan Trinh3Van Thanh Tran4Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh cityFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh cityFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh cityFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh cityFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city Pantoprazole is a first-line proton pump inhibitor drug for the treatment of gastric acid secretion disorders that is known to have minimal side effects and drug interactions. To improve its stability in gastric acid, delayedrelease microspheres containing pantoprazole was prepared by emulsification-solvent evaporation using a polymer-containing mixture of hydroxypropyl cellulose (HPC) and ethyl cellulose (EC), which was then coated by alginate and Eudragit L100. The morphological characteristics of the microspheres were examined by SEM, the particle size distribution inferred by laser diffraction, and the physical state of drug substance was measured by Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and in vitro drug release. The three formulations of microspheres chosen for this study had an average size of 100 µm. The dissolution profile showed less than 10% of the drug was released after 120 min in 0.1-M HCl and more than 75% of drug was released after 45 min in a phosphate buffer with a pH of 6.8. https://vietnamscience.vjst.vn/index.php/vjste/article/view/67delayed releaseenteric coated microspherepantoprazole |
| spellingShingle | Xuan Truong Le Hue Minh Nguyen Ngoc Quynh Le Thi Thu Loan Trinh Van Thanh Tran Formulation of enteric coated microspheres containing pantoprazole Vietnam Journal of Science, Technology and Engineering delayed release enteric coated microsphere pantoprazole |
| title | Formulation of enteric coated microspheres containing pantoprazole |
| title_full | Formulation of enteric coated microspheres containing pantoprazole |
| title_fullStr | Formulation of enteric coated microspheres containing pantoprazole |
| title_full_unstemmed | Formulation of enteric coated microspheres containing pantoprazole |
| title_short | Formulation of enteric coated microspheres containing pantoprazole |
| title_sort | formulation of enteric coated microspheres containing pantoprazole |
| topic | delayed release enteric coated microsphere pantoprazole |
| url | https://vietnamscience.vjst.vn/index.php/vjste/article/view/67 |
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