Clinical and angiographical features of first episode of acute coronary syndrome in patients with human immunodeficiency virus infection
Background Patients affected by the human immunodeficiency virus (HIV) show an increased risk of myocardial infarction. Clinical and angiographic features of HIV positive (HIV+) patients presenting with the first episode of an acute coronary syndrome (ACS) are not well defined in previous studies. O...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-04-01
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| Series: | HIV Research & Clinical Practice |
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| Online Access: | http://dx.doi.org/10.1080/25787489.2021.1911502 |
| _version_ | 1827794838685220864 |
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| author | Giuseppe Uccello Rocco Mollace Maria Stelitano Annamaria Tavernese Saverio Muscoli Marco Di Luozzo Pasquale De Vico Francesco Romeo Valeria Cammalleri |
| author_facet | Giuseppe Uccello Rocco Mollace Maria Stelitano Annamaria Tavernese Saverio Muscoli Marco Di Luozzo Pasquale De Vico Francesco Romeo Valeria Cammalleri |
| author_sort | Giuseppe Uccello |
| collection | DOAJ |
| description | Background Patients affected by the human immunodeficiency virus (HIV) show an increased risk of myocardial infarction. Clinical and angiographic features of HIV positive (HIV+) patients presenting with the first episode of an acute coronary syndrome (ACS) are not well defined in previous studies. Objective To demonstrate that HIV + patients with acute coronary syndrome had different features than non-HIV patients. Methods We identified 48 HIV + patients without previous cardiovascular events admitted to our Emergency Department with ACS diagnosis between 2012 and 2020. Clinical and angiographic characteristics were compared with a control group of 48 non-HIV consecutive patients affected by ACS as first episode. Results HIV + patients were most frequently men (87.5% vs 62.5%, p = 0.009) and younger about a decade (mean age 53.8 ± 8.2 vs 63.7 ± 11.9 years old, p < 0.0001); statistically significant hypertriglyceridemia has been found in the HIV group (178,6 ± 59,8 mg/dl vs 142,7 ± 63,7 mg/dl, p = 0.005). HIV(+) patients had a higher rate of anterior ST-elevation myocardial infarction (STEMI) (65% vs 33%, p = 0.03) and significant lesions on left anterior descending (LAD) coronary artery (83% vs 58% p = 0.01). Conclusions HIV + patients with the first episode of ACS are generally young men with higher triglycerides and most frequently presenting with anterior STEMI and LAD involvement. The strict control of risk factors and a program for the early identification of coronary artery disease are strongly recommended in this subset of patients. |
| first_indexed | 2024-03-11T18:39:36Z |
| format | Article |
| id | doaj.art-2770104397c947d29cb677afc5ff4398 |
| institution | Directory Open Access Journal |
| issn | 2578-7470 |
| language | English |
| last_indexed | 2024-03-11T18:39:36Z |
| publishDate | 2021-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | HIV Research & Clinical Practice |
| spelling | doaj.art-2770104397c947d29cb677afc5ff43982023-10-12T13:43:53ZengTaylor & Francis GroupHIV Research & Clinical Practice2578-74702021-04-01221313510.1080/25787489.2021.19115021911502Clinical and angiographical features of first episode of acute coronary syndrome in patients with human immunodeficiency virus infectionGiuseppe Uccello0Rocco Mollace1Maria Stelitano2Annamaria Tavernese3Saverio Muscoli4Marco Di Luozzo5Pasquale De Vico6Francesco Romeo7Valeria Cammalleri8Department of Cardiovascular Disease, University of Rome “Tor Vergata”Department of Cardiovascular Disease, University of Rome “Tor Vergata”Department of Cardiovascular Disease, University of Rome “Tor Vergata”Department of Cardiovascular Disease, University of Rome “Tor Vergata”Department of Cardiovascular Disease, University of Rome “Tor Vergata”Department of Cardiovascular Disease, University of Rome “Tor Vergata”Department of Anaesthesia, University of Rome “Tor Vergata”Department of Cardiovascular Disease, University of Rome “Tor Vergata”Department of Cardiovascular Disease, University of Rome “Tor Vergata”Background Patients affected by the human immunodeficiency virus (HIV) show an increased risk of myocardial infarction. Clinical and angiographic features of HIV positive (HIV+) patients presenting with the first episode of an acute coronary syndrome (ACS) are not well defined in previous studies. Objective To demonstrate that HIV + patients with acute coronary syndrome had different features than non-HIV patients. Methods We identified 48 HIV + patients without previous cardiovascular events admitted to our Emergency Department with ACS diagnosis between 2012 and 2020. Clinical and angiographic characteristics were compared with a control group of 48 non-HIV consecutive patients affected by ACS as first episode. Results HIV + patients were most frequently men (87.5% vs 62.5%, p = 0.009) and younger about a decade (mean age 53.8 ± 8.2 vs 63.7 ± 11.9 years old, p < 0.0001); statistically significant hypertriglyceridemia has been found in the HIV group (178,6 ± 59,8 mg/dl vs 142,7 ± 63,7 mg/dl, p = 0.005). HIV(+) patients had a higher rate of anterior ST-elevation myocardial infarction (STEMI) (65% vs 33%, p = 0.03) and significant lesions on left anterior descending (LAD) coronary artery (83% vs 58% p = 0.01). Conclusions HIV + patients with the first episode of ACS are generally young men with higher triglycerides and most frequently presenting with anterior STEMI and LAD involvement. The strict control of risk factors and a program for the early identification of coronary artery disease are strongly recommended in this subset of patients.http://dx.doi.org/10.1080/25787489.2021.1911502hivacute coronary syndromefirst episode |
| spellingShingle | Giuseppe Uccello Rocco Mollace Maria Stelitano Annamaria Tavernese Saverio Muscoli Marco Di Luozzo Pasquale De Vico Francesco Romeo Valeria Cammalleri Clinical and angiographical features of first episode of acute coronary syndrome in patients with human immunodeficiency virus infection HIV Research & Clinical Practice hiv acute coronary syndrome first episode |
| title | Clinical and angiographical features of first episode of acute coronary syndrome in patients with human immunodeficiency virus infection |
| title_full | Clinical and angiographical features of first episode of acute coronary syndrome in patients with human immunodeficiency virus infection |
| title_fullStr | Clinical and angiographical features of first episode of acute coronary syndrome in patients with human immunodeficiency virus infection |
| title_full_unstemmed | Clinical and angiographical features of first episode of acute coronary syndrome in patients with human immunodeficiency virus infection |
| title_short | Clinical and angiographical features of first episode of acute coronary syndrome in patients with human immunodeficiency virus infection |
| title_sort | clinical and angiographical features of first episode of acute coronary syndrome in patients with human immunodeficiency virus infection |
| topic | hiv acute coronary syndrome first episode |
| url | http://dx.doi.org/10.1080/25787489.2021.1911502 |
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