A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases
Abstract Background xSPECT Bone® (xB) is a new reconstruction algorithm developed by Siemens® in bone hybrid imaging (SPECT/CT). A CT-based tissue segmentation is incorporated into SPECT reconstruction to provide SPECT images with bone anatomy appearance. The objectives of this study were to assess...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-02-01
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| Series: | EJNMMI Research |
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| Online Access: | http://link.springer.com/article/10.1186/s13550-018-0367-7 |
| _version_ | 1818449487332376576 |
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| author | Olivier Delcroix Philippe Robin Maelenn Gouillou Alexandra Le Duc-Pennec Zarrin Alavi Pierre-Yves Le Roux Ronan Abgral Pierre-Yves Salaun David Bourhis Solène Querellou |
| author_facet | Olivier Delcroix Philippe Robin Maelenn Gouillou Alexandra Le Duc-Pennec Zarrin Alavi Pierre-Yves Le Roux Ronan Abgral Pierre-Yves Salaun David Bourhis Solène Querellou |
| author_sort | Olivier Delcroix |
| collection | DOAJ |
| description | Abstract Background xSPECT Bone® (xB) is a new reconstruction algorithm developed by Siemens® in bone hybrid imaging (SPECT/CT). A CT-based tissue segmentation is incorporated into SPECT reconstruction to provide SPECT images with bone anatomy appearance. The objectives of this study were to assess xB/CT reconstruction diagnostic reliability and accuracy in comparison with Flash 3D® (F3D)/CT in clinical routine. Two hundred thirteen consecutive patients referred to the Brest Nuclear Medicine Department for non-oncological bone diseases were evaluated retrospectively. Two hundred seven SPECT/CT were included. All SPECT/CT were independently interpreted by two nuclear medicine physicians (a junior and a senior expert) with xB/CT then with F3D/CT three months later. Inter-observer agreement (IOA) and diagnostic confidence were determined using McNemar test, and unweighted Kappa coefficient. The study objectives were then re-assessed for validation through > 18 months of clinical and paraclinical follow-up. Results No statistically significant differences between IOA xB and IOA F3D were found (p = 0.532). Agreement for xB after categorical classification of the diagnoses was high (κ xB = 0.89 [95% CI 0.84 –0.93]) but without statistically significant difference F3D (κ F3D = 0.90 [95% CI 0.86 – 0.94]). Thirty-one (14.9%) inter-reconstruction diagnostic discrepancies were observed of which 21 (10.1%) were classified as major. The follow-up confirmed the diagnosis of F3D in 10 cases, xB in 6 cases and was non-contributory in 5 cases. Conclusions xB reconstruction algorithm was found reliable, providing high interobserver agreement and similar diagnostic confidence to F3D reconstruction in clinical routine. |
| first_indexed | 2024-12-14T20:36:11Z |
| format | Article |
| id | doaj.art-27709eabbe924bd8a24f68f783c8cee2 |
| institution | Directory Open Access Journal |
| issn | 2191-219X |
| language | English |
| last_indexed | 2024-12-14T20:36:11Z |
| publishDate | 2018-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj.art-27709eabbe924bd8a24f68f783c8cee22022-12-21T22:48:23ZengSpringerOpenEJNMMI Research2191-219X2018-02-01811910.1186/s13550-018-0367-7A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseasesOlivier Delcroix0Philippe Robin1Maelenn Gouillou2Alexandra Le Duc-Pennec3Zarrin Alavi4Pierre-Yves Le Roux5Ronan Abgral6Pierre-Yves Salaun7David Bourhis8Solène Querellou9Nuclear Medicine Department, CHRU Hospital MorvanNuclear Medicine Department, CHRU Hospital MorvanCHRU BrestNuclear Medicine Department, CHRU Hospital MorvanBrest Medical University Hospital—Inserm CIC 1412Nuclear Medicine Department, CHRU Hospital MorvanNuclear Medicine Department, CHRU Hospital MorvanNuclear Medicine Department, CHRU Hospital MorvanNuclear Medicine Department, CHRU Hospital MorvanNuclear Medicine Department, CHRU Hospital MorvanAbstract Background xSPECT Bone® (xB) is a new reconstruction algorithm developed by Siemens® in bone hybrid imaging (SPECT/CT). A CT-based tissue segmentation is incorporated into SPECT reconstruction to provide SPECT images with bone anatomy appearance. The objectives of this study were to assess xB/CT reconstruction diagnostic reliability and accuracy in comparison with Flash 3D® (F3D)/CT in clinical routine. Two hundred thirteen consecutive patients referred to the Brest Nuclear Medicine Department for non-oncological bone diseases were evaluated retrospectively. Two hundred seven SPECT/CT were included. All SPECT/CT were independently interpreted by two nuclear medicine physicians (a junior and a senior expert) with xB/CT then with F3D/CT three months later. Inter-observer agreement (IOA) and diagnostic confidence were determined using McNemar test, and unweighted Kappa coefficient. The study objectives were then re-assessed for validation through > 18 months of clinical and paraclinical follow-up. Results No statistically significant differences between IOA xB and IOA F3D were found (p = 0.532). Agreement for xB after categorical classification of the diagnoses was high (κ xB = 0.89 [95% CI 0.84 –0.93]) but without statistically significant difference F3D (κ F3D = 0.90 [95% CI 0.86 – 0.94]). Thirty-one (14.9%) inter-reconstruction diagnostic discrepancies were observed of which 21 (10.1%) were classified as major. The follow-up confirmed the diagnosis of F3D in 10 cases, xB in 6 cases and was non-contributory in 5 cases. Conclusions xB reconstruction algorithm was found reliable, providing high interobserver agreement and similar diagnostic confidence to F3D reconstruction in clinical routine.http://link.springer.com/article/10.1186/s13550-018-0367-7SPECT/CTBone diseasesDiagnostic accuracyScintigraphyxSPECT Bone®Reconstruction algorithm |
| spellingShingle | Olivier Delcroix Philippe Robin Maelenn Gouillou Alexandra Le Duc-Pennec Zarrin Alavi Pierre-Yves Le Roux Ronan Abgral Pierre-Yves Salaun David Bourhis Solène Querellou A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases EJNMMI Research SPECT/CT Bone diseases Diagnostic accuracy Scintigraphy xSPECT Bone® Reconstruction algorithm |
| title | A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases |
| title_full | A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases |
| title_fullStr | A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases |
| title_full_unstemmed | A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases |
| title_short | A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases |
| title_sort | new spect ct reconstruction algorithm reliability and accuracy in clinical routine for non oncologic bone diseases |
| topic | SPECT/CT Bone diseases Diagnostic accuracy Scintigraphy xSPECT Bone® Reconstruction algorithm |
| url | http://link.springer.com/article/10.1186/s13550-018-0367-7 |
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