Evolutionary innovation through transcription factor rewiring in microbes is shaped by levels of transcription factor activity, expression, and existing connectivity.

The survival of a population during environmental shifts depends on whether the rate of phenotypic adaptation keeps up with the rate of changing conditions. A common way to achieve this is via change to gene regulatory network (GRN) connections-known as rewiring-that facilitate novel interactions an...

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Bibliographic Details
Main Authors: Matthew J Shepherd, Aidan P Pierce, Tiffany B Taylor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-10-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002348&type=printable

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