In utero particulate matter exposure in association with newborn mitochondrial ND4L10550A>G heteroplasmy and its role in overweight during early childhood
Abstract Background Mitochondria play an important role in the energy metabolism and are susceptible to environmental pollution. Prenatal air pollution exposure has been linked with childhood obesity. Placental mtDNA mutations have been associated with prenatal particulate matter exposure and MT-ND4...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
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BMC
2022-09-01
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| Series: | Environmental Health |
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| Online Access: | https://doi.org/10.1186/s12940-022-00899-z |
| _version_ | 1798001658358136832 |
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| author | Charlotte Cosemans Congrong Wang Rossella Alfano Dries S. Martens Hanne Sleurs Yinthe Dockx Kenneth Vanbrabant Bram G. Janssen Charlotte Vanpoucke Wouter Lefebvre Karen Smeets Tim S. Nawrot Michelle Plusquin |
| author_facet | Charlotte Cosemans Congrong Wang Rossella Alfano Dries S. Martens Hanne Sleurs Yinthe Dockx Kenneth Vanbrabant Bram G. Janssen Charlotte Vanpoucke Wouter Lefebvre Karen Smeets Tim S. Nawrot Michelle Plusquin |
| author_sort | Charlotte Cosemans |
| collection | DOAJ |
| description | Abstract Background Mitochondria play an important role in the energy metabolism and are susceptible to environmental pollution. Prenatal air pollution exposure has been linked with childhood obesity. Placental mtDNA mutations have been associated with prenatal particulate matter exposure and MT-ND4L10550A>G heteroplasmy has been associated with BMI in adults. Therefore, we hypothesized that in utero PM2.5 exposure is associated with cord blood MT-ND4L10550A>G heteroplasmy and early life growth. In addition, the role of cord blood MT-ND4L10550A>G heteroplasmy in overweight during early childhood is investigated. Methods This study included 386 mother-newborn pairs. Outdoor PM2.5 concentrations were determined at the maternal residential address. Cord blood MT-ND4L10550A>G heteroplasmy was determined using Droplet Digital PCR. Associations were explored using logistic regression models and distributed lag linear models. Mediation analysis was performed to quantify the effects of prenatal PM2.5 exposure on childhood overweight mediated by cord blood MT-ND4L10550A>G heteroplasmy. Results Prenatal PM2.5 exposure was positively associated with childhood overweight during the whole pregnancy (OR = 2.33; 95% CI: 1.20 to 4.51; p = 0.01), which was mainly driven by the second trimester. In addition, prenatal PM2.5 exposure was associated with cord blood MT-ND4L10550A>G heteroplasmy from gestational week 9 – 13. The largest effect was observed in week 10, where a 5 µg/m3 increment in PM2.5 was linked with cord blood MT-ND4L10550A>G heteroplasmy (OR = 0.93; 95% CI: 0.87 to 0.99). Cord blood MT-ND4L10550A>G heteroplasmy was also linked with childhood overweight (OR = 3.04; 95% CI: 1.15 to 7.50; p = 0.02). The effect of prenatal PM2.5 exposure on childhood overweight was mainly direct (total effect OR = 1.18; 95% CI: 0.99 to 1.36; natural direct effect OR = 1.20; 95% CI: 1.01 to 1.36)) and was not mediated by cord blood MT-ND4L10550A>G heteroplasmy. Conclusions Cord blood MT-ND4L10550A>G heteroplasmy was linked with childhood overweight. In addition, in utero exposure to PM2.5 during the first trimester of pregnancy was associated with cord blood MT-ND4L10550A>G heteroplasmy in newborns. Our analysis did not reveal any mediation of cord blood MT-ND4L10550A>G heteroplasmy in the association between PM2.5 exposure and childhood overweight. |
| first_indexed | 2024-04-11T11:39:48Z |
| format | Article |
| id | doaj.art-27716bb5609949b3b11aeab12dd645fb |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-04-11T11:39:48Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-27716bb5609949b3b11aeab12dd645fb2022-12-22T04:25:51ZengBMCEnvironmental Health1476-069X2022-09-0121111210.1186/s12940-022-00899-zIn utero particulate matter exposure in association with newborn mitochondrial ND4L10550A>G heteroplasmy and its role in overweight during early childhoodCharlotte Cosemans0Congrong Wang1Rossella Alfano2Dries S. Martens3Hanne Sleurs4Yinthe Dockx5Kenneth Vanbrabant6Bram G. Janssen7Charlotte Vanpoucke8Wouter Lefebvre9Karen Smeets10Tim S. Nawrot11Michelle Plusquin12Centre for Environmental Sciences, Hasselt UniversityCentre for Environmental Sciences, Hasselt UniversityCentre for Environmental Sciences, Hasselt UniversityCentre for Environmental Sciences, Hasselt UniversityCentre for Environmental Sciences, Hasselt UniversityCentre for Environmental Sciences, Hasselt UniversityCentre for Environmental Sciences, Hasselt UniversityCentre for Environmental Sciences, Hasselt UniversityBelgian Interregional Environment Agency, IRCEL-CELINEFlemish Institute for Technological Research, VITOCentre for Environmental Sciences, Hasselt UniversityCentre for Environmental Sciences, Hasselt UniversityCentre for Environmental Sciences, Hasselt UniversityAbstract Background Mitochondria play an important role in the energy metabolism and are susceptible to environmental pollution. Prenatal air pollution exposure has been linked with childhood obesity. Placental mtDNA mutations have been associated with prenatal particulate matter exposure and MT-ND4L10550A>G heteroplasmy has been associated with BMI in adults. Therefore, we hypothesized that in utero PM2.5 exposure is associated with cord blood MT-ND4L10550A>G heteroplasmy and early life growth. In addition, the role of cord blood MT-ND4L10550A>G heteroplasmy in overweight during early childhood is investigated. Methods This study included 386 mother-newborn pairs. Outdoor PM2.5 concentrations were determined at the maternal residential address. Cord blood MT-ND4L10550A>G heteroplasmy was determined using Droplet Digital PCR. Associations were explored using logistic regression models and distributed lag linear models. Mediation analysis was performed to quantify the effects of prenatal PM2.5 exposure on childhood overweight mediated by cord blood MT-ND4L10550A>G heteroplasmy. Results Prenatal PM2.5 exposure was positively associated with childhood overweight during the whole pregnancy (OR = 2.33; 95% CI: 1.20 to 4.51; p = 0.01), which was mainly driven by the second trimester. In addition, prenatal PM2.5 exposure was associated with cord blood MT-ND4L10550A>G heteroplasmy from gestational week 9 – 13. The largest effect was observed in week 10, where a 5 µg/m3 increment in PM2.5 was linked with cord blood MT-ND4L10550A>G heteroplasmy (OR = 0.93; 95% CI: 0.87 to 0.99). Cord blood MT-ND4L10550A>G heteroplasmy was also linked with childhood overweight (OR = 3.04; 95% CI: 1.15 to 7.50; p = 0.02). The effect of prenatal PM2.5 exposure on childhood overweight was mainly direct (total effect OR = 1.18; 95% CI: 0.99 to 1.36; natural direct effect OR = 1.20; 95% CI: 1.01 to 1.36)) and was not mediated by cord blood MT-ND4L10550A>G heteroplasmy. Conclusions Cord blood MT-ND4L10550A>G heteroplasmy was linked with childhood overweight. In addition, in utero exposure to PM2.5 during the first trimester of pregnancy was associated with cord blood MT-ND4L10550A>G heteroplasmy in newborns. Our analysis did not reveal any mediation of cord blood MT-ND4L10550A>G heteroplasmy in the association between PM2.5 exposure and childhood overweight.https://doi.org/10.1186/s12940-022-00899-zMitochondriaSNPAir pollutionDLMsChildhood overweight |
| spellingShingle | Charlotte Cosemans Congrong Wang Rossella Alfano Dries S. Martens Hanne Sleurs Yinthe Dockx Kenneth Vanbrabant Bram G. Janssen Charlotte Vanpoucke Wouter Lefebvre Karen Smeets Tim S. Nawrot Michelle Plusquin In utero particulate matter exposure in association with newborn mitochondrial ND4L10550A>G heteroplasmy and its role in overweight during early childhood Environmental Health Mitochondria SNP Air pollution DLMs Childhood overweight |
| title | In utero particulate matter exposure in association with newborn mitochondrial ND4L10550A>G heteroplasmy and its role in overweight during early childhood |
| title_full | In utero particulate matter exposure in association with newborn mitochondrial ND4L10550A>G heteroplasmy and its role in overweight during early childhood |
| title_fullStr | In utero particulate matter exposure in association with newborn mitochondrial ND4L10550A>G heteroplasmy and its role in overweight during early childhood |
| title_full_unstemmed | In utero particulate matter exposure in association with newborn mitochondrial ND4L10550A>G heteroplasmy and its role in overweight during early childhood |
| title_short | In utero particulate matter exposure in association with newborn mitochondrial ND4L10550A>G heteroplasmy and its role in overweight during early childhood |
| title_sort | in utero particulate matter exposure in association with newborn mitochondrial nd4l10550a g heteroplasmy and its role in overweight during early childhood |
| topic | Mitochondria SNP Air pollution DLMs Childhood overweight |
| url | https://doi.org/10.1186/s12940-022-00899-z |
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