Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events.
Clinical manifestations and outcomes of atherosclerotic disease differ between ethnic groups. In addition, the prevalence of risk factors is substantially different. Primary prevention programs are based on data derived from almost exclusively White people. We investigated how race/ethnic difference...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4489855?pdf=render |
| _version_ | 1818555452515942400 |
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| author | Crystel M Gijsberts Karlijn A Groenewegen Imo E Hoefer Marinus J C Eijkemans Folkert W Asselbergs Todd J Anderson Annie R Britton Jacqueline M Dekker Gunnar Engström Greg W Evans Jacqueline de Graaf Diederick E Grobbee Bo Hedblad Suzanne Holewijn Ai Ikeda Kazuo Kitagawa Akihiko Kitamura Dominique P V de Kleijn Eva M Lonn Matthias W Lorenz Ellisiv B Mathiesen Giel Nijpels Shuhei Okazaki Daniel H O'Leary Gerard Pasterkamp Sanne A E Peters Joseph F Polak Jacqueline F Price Christine Robertson Christopher M Rembold Maria Rosvall Tatjana Rundek Jukka T Salonen Matthias Sitzer Coen D A Stehouwer Michiel L Bots Hester M den Ruijter |
| author_facet | Crystel M Gijsberts Karlijn A Groenewegen Imo E Hoefer Marinus J C Eijkemans Folkert W Asselbergs Todd J Anderson Annie R Britton Jacqueline M Dekker Gunnar Engström Greg W Evans Jacqueline de Graaf Diederick E Grobbee Bo Hedblad Suzanne Holewijn Ai Ikeda Kazuo Kitagawa Akihiko Kitamura Dominique P V de Kleijn Eva M Lonn Matthias W Lorenz Ellisiv B Mathiesen Giel Nijpels Shuhei Okazaki Daniel H O'Leary Gerard Pasterkamp Sanne A E Peters Joseph F Polak Jacqueline F Price Christine Robertson Christopher M Rembold Maria Rosvall Tatjana Rundek Jukka T Salonen Matthias Sitzer Coen D A Stehouwer Michiel L Bots Hester M den Ruijter |
| author_sort | Crystel M Gijsberts |
| collection | DOAJ |
| description | Clinical manifestations and outcomes of atherosclerotic disease differ between ethnic groups. In addition, the prevalence of risk factors is substantially different. Primary prevention programs are based on data derived from almost exclusively White people. We investigated how race/ethnic differences modify the associations of established risk factors with atherosclerosis and cardiovascular events.We used data from an ongoing individual participant meta-analysis involving 17 population-based cohorts worldwide. We selected 60,211 participants without cardiovascular disease at baseline with available data on ethnicity (White, Black, Asian or Hispanic). We generated a multivariable linear regression model containing risk factors and ethnicity predicting mean common carotid intima-media thickness (CIMT) and a multivariable Cox regression model predicting myocardial infarction or stroke. For each risk factor we assessed how the association with the preclinical and clinical measures of cardiovascular atherosclerotic disease was affected by ethnicity.Ethnicity appeared to significantly modify the associations between risk factors and CIMT and cardiovascular events. The association between age and CIMT was weaker in Blacks and Hispanics. Systolic blood pressure associated more strongly with CIMT in Asians. HDL cholesterol and smoking associated less with CIMT in Blacks. Furthermore, the association of age and total cholesterol levels with the occurrence of cardiovascular events differed between Blacks and Whites.The magnitude of associations between risk factors and the presence of atherosclerotic disease differs between race/ethnic groups. These subtle, yet significant differences provide insight in the etiology of cardiovascular disease among race/ethnic groups. These insights aid the race/ethnic-specific implementation of primary prevention. |
| first_indexed | 2024-12-12T09:53:39Z |
| format | Article |
| id | doaj.art-27732433db7648ca8dcf2788a1428932 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T09:53:39Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-27732433db7648ca8dcf2788a14289322022-12-22T00:28:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01107e013232110.1371/journal.pone.0132321Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events.Crystel M GijsbertsKarlijn A GroenewegenImo E HoeferMarinus J C EijkemansFolkert W AsselbergsTodd J AndersonAnnie R BrittonJacqueline M DekkerGunnar EngströmGreg W EvansJacqueline de GraafDiederick E GrobbeeBo HedbladSuzanne HolewijnAi IkedaKazuo KitagawaAkihiko KitamuraDominique P V de KleijnEva M LonnMatthias W LorenzEllisiv B MathiesenGiel NijpelsShuhei OkazakiDaniel H O'LearyGerard PasterkampSanne A E PetersJoseph F PolakJacqueline F PriceChristine RobertsonChristopher M RemboldMaria RosvallTatjana RundekJukka T SalonenMatthias SitzerCoen D A StehouwerMichiel L BotsHester M den RuijterClinical manifestations and outcomes of atherosclerotic disease differ between ethnic groups. In addition, the prevalence of risk factors is substantially different. Primary prevention programs are based on data derived from almost exclusively White people. We investigated how race/ethnic differences modify the associations of established risk factors with atherosclerosis and cardiovascular events.We used data from an ongoing individual participant meta-analysis involving 17 population-based cohorts worldwide. We selected 60,211 participants without cardiovascular disease at baseline with available data on ethnicity (White, Black, Asian or Hispanic). We generated a multivariable linear regression model containing risk factors and ethnicity predicting mean common carotid intima-media thickness (CIMT) and a multivariable Cox regression model predicting myocardial infarction or stroke. For each risk factor we assessed how the association with the preclinical and clinical measures of cardiovascular atherosclerotic disease was affected by ethnicity.Ethnicity appeared to significantly modify the associations between risk factors and CIMT and cardiovascular events. The association between age and CIMT was weaker in Blacks and Hispanics. Systolic blood pressure associated more strongly with CIMT in Asians. HDL cholesterol and smoking associated less with CIMT in Blacks. Furthermore, the association of age and total cholesterol levels with the occurrence of cardiovascular events differed between Blacks and Whites.The magnitude of associations between risk factors and the presence of atherosclerotic disease differs between race/ethnic groups. These subtle, yet significant differences provide insight in the etiology of cardiovascular disease among race/ethnic groups. These insights aid the race/ethnic-specific implementation of primary prevention.http://europepmc.org/articles/PMC4489855?pdf=render |
| spellingShingle | Crystel M Gijsberts Karlijn A Groenewegen Imo E Hoefer Marinus J C Eijkemans Folkert W Asselbergs Todd J Anderson Annie R Britton Jacqueline M Dekker Gunnar Engström Greg W Evans Jacqueline de Graaf Diederick E Grobbee Bo Hedblad Suzanne Holewijn Ai Ikeda Kazuo Kitagawa Akihiko Kitamura Dominique P V de Kleijn Eva M Lonn Matthias W Lorenz Ellisiv B Mathiesen Giel Nijpels Shuhei Okazaki Daniel H O'Leary Gerard Pasterkamp Sanne A E Peters Joseph F Polak Jacqueline F Price Christine Robertson Christopher M Rembold Maria Rosvall Tatjana Rundek Jukka T Salonen Matthias Sitzer Coen D A Stehouwer Michiel L Bots Hester M den Ruijter Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events. PLoS ONE |
| title | Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events. |
| title_full | Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events. |
| title_fullStr | Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events. |
| title_full_unstemmed | Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events. |
| title_short | Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events. |
| title_sort | race ethnic differences in the associations of the framingham risk factors with carotid imt and cardiovascular events |
| url | http://europepmc.org/articles/PMC4489855?pdf=render |
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