Recent Outbreaks of Diphtheria in Dibrugarh District, Assam, India
Diphtheria is still a significant child health problem in countries with low immunization coverage. Reports of diphtheria in adult population are also increasing. Here we describe three recent outbreaks of diphtheria in Dibrugarh district, Assam in two consecutive years. The study was undertaken i...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-07-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8144/20212_CE(RA1)_F(T)_PF1(ASAK)_PFA(AK)_PFA2(ESAK).pdf |
| _version_ | 1817997691978776576 |
|---|---|
| author | Partha Pratim Das Saurav Jyoti Patgiri Lahari Saikia Debosmita Paul |
| author_facet | Partha Pratim Das Saurav Jyoti Patgiri Lahari Saikia Debosmita Paul |
| author_sort | Partha Pratim Das |
| collection | DOAJ |
| description | Diphtheria is still a significant child health problem in countries with low immunization coverage. Reports of diphtheria in adult population
are also increasing. Here we describe three recent outbreaks of diphtheria in Dibrugarh district, Assam in two consecutive years. The
study was undertaken in Assam Medical College & Hospital, Dibrugarh after the diagnosis of two Diphtheria cases in the month of
September and October 2015 and another in January 2016. Outbreak investigation was done after defining operational definition and
throat swabs were collected from thirty three (33) individuals including three (3) index cases and thirty (30) close contacts. Diagnosis was
done by clinical findings, direct microscopy, bacteriological culture and in-house designed multiplex Polymerase Chain Reaction (PCR)
of the isolates for the expression of Corynebacterium diphtheriae specific rpoB gene and tox gene. Out of the 10 confirmed cases, 2 and
7 were in the first two outbreaks while only one in the third outbreak respectively. All the cases were of age > 10 years, unimmunized or
partially immunized.
The overall mortality was 20%. PCR results revealed all the culture positive isolates to be tox gene positive. Diphtheria is a resurgent
problem in our region with a significant age shift towards adult. |
| first_indexed | 2024-04-14T02:42:07Z |
| format | Article |
| id | doaj.art-27732c714e7f44989fa68963d2cc16f6 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-14T02:42:07Z |
| publishDate | 2016-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-27732c714e7f44989fa68963d2cc16f62022-12-22T02:16:51ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-07-01107DR01DR0310.7860/JCDR/2016/20212.8144Recent Outbreaks of Diphtheria in Dibrugarh District, Assam, IndiaPartha Pratim Das0Saurav Jyoti Patgiri1Lahari Saikia2Debosmita Paul3Demonstrator, Department of Microbiology, Assam Medical College & Hospital, Assam, India.Research Scientist II, Department of Multidisciplinary Research Unit (ICMR), Assam Medical College & Hospital, Assam, India.Professor, Department of Microbiology, Assam Medical College & Hospital, Assam, India.Post Graduate Trainee, Department of Microbiology, Assam Medical College & Hospital, Assam, India.Diphtheria is still a significant child health problem in countries with low immunization coverage. Reports of diphtheria in adult population are also increasing. Here we describe three recent outbreaks of diphtheria in Dibrugarh district, Assam in two consecutive years. The study was undertaken in Assam Medical College & Hospital, Dibrugarh after the diagnosis of two Diphtheria cases in the month of September and October 2015 and another in January 2016. Outbreak investigation was done after defining operational definition and throat swabs were collected from thirty three (33) individuals including three (3) index cases and thirty (30) close contacts. Diagnosis was done by clinical findings, direct microscopy, bacteriological culture and in-house designed multiplex Polymerase Chain Reaction (PCR) of the isolates for the expression of Corynebacterium diphtheriae specific rpoB gene and tox gene. Out of the 10 confirmed cases, 2 and 7 were in the first two outbreaks while only one in the third outbreak respectively. All the cases were of age > 10 years, unimmunized or partially immunized. The overall mortality was 20%. PCR results revealed all the culture positive isolates to be tox gene positive. Diphtheria is a resurgent problem in our region with a significant age shift towards adult.https://jcdr.net/articles/PDF/8144/20212_CE(RA1)_F(T)_PF1(ASAK)_PFA(AK)_PFA2(ESAK).pdfcorynebacterium diphtheriaediphtheria antitoxinimmunizationtox gene |
| spellingShingle | Partha Pratim Das Saurav Jyoti Patgiri Lahari Saikia Debosmita Paul Recent Outbreaks of Diphtheria in Dibrugarh District, Assam, India Journal of Clinical and Diagnostic Research corynebacterium diphtheriae diphtheria antitoxin immunization tox gene |
| title | Recent Outbreaks of Diphtheria in Dibrugarh District, Assam, India |
| title_full | Recent Outbreaks of Diphtheria in Dibrugarh District, Assam, India |
| title_fullStr | Recent Outbreaks of Diphtheria in Dibrugarh District, Assam, India |
| title_full_unstemmed | Recent Outbreaks of Diphtheria in Dibrugarh District, Assam, India |
| title_short | Recent Outbreaks of Diphtheria in Dibrugarh District, Assam, India |
| title_sort | recent outbreaks of diphtheria in dibrugarh district assam india |
| topic | corynebacterium diphtheriae diphtheria antitoxin immunization tox gene |
| url | https://jcdr.net/articles/PDF/8144/20212_CE(RA1)_F(T)_PF1(ASAK)_PFA(AK)_PFA2(ESAK).pdf |
| work_keys_str_mv | AT parthapratimdas recentoutbreaksofdiphtheriaindibrugarhdistrictassamindia AT sauravjyotipatgiri recentoutbreaksofdiphtheriaindibrugarhdistrictassamindia AT laharisaikia recentoutbreaksofdiphtheriaindibrugarhdistrictassamindia AT debosmitapaul recentoutbreaksofdiphtheriaindibrugarhdistrictassamindia |