Two orthorhombic polymorphs of hydromorphone

Two orthorhombic polymorphs of hydromorphone

Conditions to obtain two polymorphic forms by crystallization from solution were determined for the analgesic drug hydromorphone [C17H19NO3; systematic name: (4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one]. These two crystalline forms,...

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Bibliographic Details
Main Authors: Jaroslaw Mazurek, Marcel Hoffmann, Ana Fernandez Casares, D. Phillip Cox, Mathew D. Minardi, Josh Sasine
Format: Article
Language:English
Published: International Union of Crystallography 2016-05-01
Series:Acta Crystallographica Section E: Crystallographic Communications
Subjects:
crystal structure
polymorphism
hydromorphone,hydrogen bonding
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2056989016006563

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