Representation of visual landmarks in retrosplenial cortex
The process by which visual information is incorporated into the brain’s spatial framework to represent landmarks is poorly understood. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-dependent behavioral task in which...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-03-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/51458 |
| _version_ | 1811201005260374016 |
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| author | Lukas F Fischer Raul Mojica Soto-Albors Friederike Buck Mark T Harnett |
| author_facet | Lukas F Fischer Raul Mojica Soto-Albors Friederike Buck Mark T Harnett |
| author_sort | Lukas F Fischer |
| collection | DOAJ |
| description | The process by which visual information is incorporated into the brain’s spatial framework to represent landmarks is poorly understood. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-dependent behavioral task in which head-fixed mice learned the spatial relationship between visual landmark cues and hidden reward locations. Two-photon imaging revealed that these cues served as dominant reference points for most task-active neurons and anchored the spatial code in RSC. This encoding was more robust after task acquisition. Decoupling the virtual environment from mouse behavior degraded spatial representations and provided evidence that supralinear integration of visual and motor inputs contributes to landmark encoding. V1 axons recorded in RSC were less modulated by task engagement but showed surprisingly similar spatial tuning. Our data indicate that landmark representations in RSC are the result of local integration of visual, motor, and spatial information. |
| first_indexed | 2024-04-12T02:14:21Z |
| format | Article |
| id | doaj.art-2774605f1731484aa0b053cd96c0600d |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:14:21Z |
| publishDate | 2020-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-2774605f1731484aa0b053cd96c0600d2022-12-22T03:52:18ZengeLife Sciences Publications LtdeLife2050-084X2020-03-01910.7554/eLife.51458Representation of visual landmarks in retrosplenial cortexLukas F Fischer0https://orcid.org/0000-0001-9422-3798Raul Mojica Soto-Albors1https://orcid.org/0000-0002-6987-5417Friederike Buck2Mark T Harnett3https://orcid.org/0000-0002-5301-1139Department of Brain and Cognitive Sciences, MGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United StatesDepartment of Brain and Cognitive Sciences, MGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United StatesDepartment of Brain and Cognitive Sciences, MGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United StatesDepartment of Brain and Cognitive Sciences, MGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United StatesThe process by which visual information is incorporated into the brain’s spatial framework to represent landmarks is poorly understood. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-dependent behavioral task in which head-fixed mice learned the spatial relationship between visual landmark cues and hidden reward locations. Two-photon imaging revealed that these cues served as dominant reference points for most task-active neurons and anchored the spatial code in RSC. This encoding was more robust after task acquisition. Decoupling the virtual environment from mouse behavior degraded spatial representations and provided evidence that supralinear integration of visual and motor inputs contributes to landmark encoding. V1 axons recorded in RSC were less modulated by task engagement but showed surprisingly similar spatial tuning. Our data indicate that landmark representations in RSC are the result of local integration of visual, motor, and spatial information.https://elifesciences.org/articles/51458retrosplenial cortexsensorimotor integrationspatial navigationvisual cortexpopulation imagingbehavior |
| spellingShingle | Lukas F Fischer Raul Mojica Soto-Albors Friederike Buck Mark T Harnett Representation of visual landmarks in retrosplenial cortex eLife retrosplenial cortex sensorimotor integration spatial navigation visual cortex population imaging behavior |
| title | Representation of visual landmarks in retrosplenial cortex |
| title_full | Representation of visual landmarks in retrosplenial cortex |
| title_fullStr | Representation of visual landmarks in retrosplenial cortex |
| title_full_unstemmed | Representation of visual landmarks in retrosplenial cortex |
| title_short | Representation of visual landmarks in retrosplenial cortex |
| title_sort | representation of visual landmarks in retrosplenial cortex |
| topic | retrosplenial cortex sensorimotor integration spatial navigation visual cortex population imaging behavior |
| url | https://elifesciences.org/articles/51458 |
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