Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro
The sebaceous gland (SG) has been proposed to be replenished by pools of cells, including a population in the SG base, marked by Blimp1. Here, the authors show that Blimp1+ cells can establish an organoid model of the SG, which is regulated by c-Myc and can recapitulate the early stages of acne vulg...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10261-6 |
| _version_ | 1819126326797271040 |
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| author | Alona Feldman Dzmitry Mukha Itzhak I. Maor Egor Sedov Elle Koren Yahav Yosefzon Tomer Shlomi Yaron Fuchs |
| author_facet | Alona Feldman Dzmitry Mukha Itzhak I. Maor Egor Sedov Elle Koren Yahav Yosefzon Tomer Shlomi Yaron Fuchs |
| author_sort | Alona Feldman |
| collection | DOAJ |
| description | The sebaceous gland (SG) has been proposed to be replenished by pools of cells, including a population in the SG base, marked by Blimp1. Here, the authors show that Blimp1+ cells can establish an organoid model of the SG, which is regulated by c-Myc and can recapitulate the early stages of acne vulgaris. |
| first_indexed | 2024-12-22T07:54:16Z |
| format | Article |
| id | doaj.art-277621f55aff4e1c8b1f5e1e71c79fdf |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T07:54:16Z |
| publishDate | 2019-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-277621f55aff4e1c8b1f5e1e71c79fdf2022-12-21T18:33:24ZengNature PortfolioNature Communications2041-17232019-05-0110111310.1038/s41467-019-10261-6Blimp1+ cells generate functional mouse sebaceous gland organoids in vitroAlona Feldman0Dzmitry Mukha1Itzhak I. Maor2Egor Sedov3Elle Koren4Yahav Yosefzon5Tomer Shlomi6Yaron Fuchs7Laboratory of Stem Cell Biology and Regenerative Medicine, Department of Biology, Technion Israel Institute of TechnologyLorry Lokey Interdisciplinary Center for Life Sciences & Engineering, Technion Israel Institute of TechnologyLaboratory of Stem Cell Biology and Regenerative Medicine, Department of Biology, Technion Israel Institute of TechnologyLaboratory of Stem Cell Biology and Regenerative Medicine, Department of Biology, Technion Israel Institute of TechnologyLaboratory of Stem Cell Biology and Regenerative Medicine, Department of Biology, Technion Israel Institute of TechnologyLaboratory of Stem Cell Biology and Regenerative Medicine, Department of Biology, Technion Israel Institute of TechnologyLorry Lokey Interdisciplinary Center for Life Sciences & Engineering, Technion Israel Institute of TechnologyLaboratory of Stem Cell Biology and Regenerative Medicine, Department of Biology, Technion Israel Institute of TechnologyThe sebaceous gland (SG) has been proposed to be replenished by pools of cells, including a population in the SG base, marked by Blimp1. Here, the authors show that Blimp1+ cells can establish an organoid model of the SG, which is regulated by c-Myc and can recapitulate the early stages of acne vulgaris.https://doi.org/10.1038/s41467-019-10261-6 |
| spellingShingle | Alona Feldman Dzmitry Mukha Itzhak I. Maor Egor Sedov Elle Koren Yahav Yosefzon Tomer Shlomi Yaron Fuchs Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro Nature Communications |
| title | Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro |
| title_full | Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro |
| title_fullStr | Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro |
| title_full_unstemmed | Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro |
| title_short | Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro |
| title_sort | blimp1 cells generate functional mouse sebaceous gland organoids in vitro |
| url | https://doi.org/10.1038/s41467-019-10261-6 |
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