Computer Modeling of D, L – Homocysteic Acid Microinjection into the Bötzinger Complex Area
The impact of D,L – homocysteic acid (DLH) microinjection (non-specific glutamate receptor agonist that causes excitation of neurons) into the Bötzinger complex area (BOT) was simulated using computer model of quiet breathing and cough reflex. Integrated signals from simulated neuronal populations i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2022-04-01
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| Series: | Acta Medica Martiniana |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acm-2022-0002 |
| _version_ | 1811239756441321472 |
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| author | Marcel Veternik Lukas Martvon Jakub Misek Michal Simera Ivan Poliacek |
| author_facet | Marcel Veternik Lukas Martvon Jakub Misek Michal Simera Ivan Poliacek |
| author_sort | Marcel Veternik |
| collection | DOAJ |
| description | The impact of D,L – homocysteic acid (DLH) microinjection (non-specific glutamate receptor agonist that causes excitation of neurons) into the Bötzinger complex area (BOT) was simulated using computer model of quiet breathing and cough reflex. Integrated signals from simulated neuronal populations innervating inspiratory phrenic and expiratory lumbar motoneurons were obtained. We analysed durations and amplitudes of these “pre-phrenic and pre-lumbar” activities during quiet breathing and cough reflex and the number of coughs elicited by a fictive 10-second-long stimulation. Model fibre population provides virtual DLH related excitation to expiratory neuronal populations with augmenting discharge pattern (BOT neurons). The excitation was modelled by a higher number of fibres and terminals (simulated a higher number of excitatory inputs) or by a higher synaptic strength (simulated a higher effect of excitatory inputs). |
| first_indexed | 2024-04-12T13:06:44Z |
| format | Article |
| id | doaj.art-2777ef5bc2744edaa6a18610e59b6108 |
| institution | Directory Open Access Journal |
| issn | 1338-4139 |
| language | English |
| last_indexed | 2024-04-12T13:06:44Z |
| publishDate | 2022-04-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Medica Martiniana |
| spelling | doaj.art-2777ef5bc2744edaa6a18610e59b61082022-12-22T03:32:00ZengSciendoActa Medica Martiniana1338-41392022-04-0122181410.2478/acm-2022-0002Computer Modeling of D, L – Homocysteic Acid Microinjection into the Bötzinger Complex AreaMarcel Veternik0Lukas Martvon1Jakub Misek2Michal Simera3Ivan Poliacek4Department of Medical Biophysics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovak RepublicMedical Education Support Center, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovak RepublicDepartment of Medical Biophysics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovak RepublicDepartment of Medical Biophysics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovak RepublicDepartment of Medical Biophysics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovak RepublicThe impact of D,L – homocysteic acid (DLH) microinjection (non-specific glutamate receptor agonist that causes excitation of neurons) into the Bötzinger complex area (BOT) was simulated using computer model of quiet breathing and cough reflex. Integrated signals from simulated neuronal populations innervating inspiratory phrenic and expiratory lumbar motoneurons were obtained. We analysed durations and amplitudes of these “pre-phrenic and pre-lumbar” activities during quiet breathing and cough reflex and the number of coughs elicited by a fictive 10-second-long stimulation. Model fibre population provides virtual DLH related excitation to expiratory neuronal populations with augmenting discharge pattern (BOT neurons). The excitation was modelled by a higher number of fibres and terminals (simulated a higher number of excitatory inputs) or by a higher synaptic strength (simulated a higher effect of excitatory inputs).https://doi.org/10.2478/acm-2022-0002coughbreathingsimulationmodulationexcitationneuron |
| spellingShingle | Marcel Veternik Lukas Martvon Jakub Misek Michal Simera Ivan Poliacek Computer Modeling of D, L – Homocysteic Acid Microinjection into the Bötzinger Complex Area Acta Medica Martiniana cough breathing simulation modulation excitation neuron |
| title | Computer Modeling of D, L – Homocysteic Acid Microinjection into the Bötzinger Complex Area |
| title_full | Computer Modeling of D, L – Homocysteic Acid Microinjection into the Bötzinger Complex Area |
| title_fullStr | Computer Modeling of D, L – Homocysteic Acid Microinjection into the Bötzinger Complex Area |
| title_full_unstemmed | Computer Modeling of D, L – Homocysteic Acid Microinjection into the Bötzinger Complex Area |
| title_short | Computer Modeling of D, L – Homocysteic Acid Microinjection into the Bötzinger Complex Area |
| title_sort | computer modeling of d l homocysteic acid microinjection into the botzinger complex area |
| topic | cough breathing simulation modulation excitation neuron |
| url | https://doi.org/10.2478/acm-2022-0002 |
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