NadA3 Structures Reveal Undecad Coiled Coils and LOX1 Binding Regions Competed by Meningococcus B Vaccine-Elicited Human Antibodies

NadA3 Structures Reveal Undecad Coiled Coils and LOX1 Binding Regions Competed by Meningococcus B Vaccine-Elicited Human Antibodies

ABSTRACT Neisseria meningitidis serogroup B (MenB) is a major cause of sepsis and invasive meningococcal disease. A multicomponent vaccine, 4CMenB, is approved for protection against MenB. Neisserial adhesin A (NadA) is one of the main vaccine antigens, acts in host cell adhesion, and may influence...

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Bibliographic Details
Main Authors: Alessia Liguori, Lucia Dello Iacono, Giulietta Maruggi, Barbara Benucci, Marcello Merola, Paola Lo Surdo, Jacinto López-Sagaseta, Mariagrazia Pizza, Enrico Malito, Matthew J. Bottomley
Format: Article
Language:English
Published: American Society for Microbiology 2018-11-01
Series:mBio
Subjects:
LOX-1 receptor
neisserial adhesin A
monoclonal antibody epitopes
three-dimensional structure
vaccine antigen
Online Access:https://journals.asm.org/doi/10.1128/mBio.01914-18

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