Green synthesis of metallic nanoparticles using pectin as a reducing agent: a systematic review of the biological activities
Context Pectin is a plant heteropolysaccharide that is biocompatible and biodegradable, enabling it to be an excellent reducing agent (green synthesis) for metallic nanoparticles (MNPs). Nevertheless, in the biological industry, pectin has been left behind in synthesising MNPs, for no known reason....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Pharmaceutical Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/13880209.2021.1910716 |
| _version_ | 1818572565015166976 |
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| author | Kogilavanee Devasvaran Vuanghao Lim |
| author_facet | Kogilavanee Devasvaran Vuanghao Lim |
| author_sort | Kogilavanee Devasvaran |
| collection | DOAJ |
| description | Context Pectin is a plant heteropolysaccharide that is biocompatible and biodegradable, enabling it to be an excellent reducing agent (green synthesis) for metallic nanoparticles (MNPs). Nevertheless, in the biological industry, pectin has been left behind in synthesising MNPs, for no known reason. Objective To systematically review the biological activities of pectin synthesised MNPs (Pe-MNPs). Methods The databases Springer Link, Scopus, ScienceDirect, Google Scholar, PubMed, Mendeley, and ResearchGate were systematically searched from the date of their inception until 10th February 2020. Pectin, green synthesis, metallic nanoparticles, reducing agent and biological activities were among the key terms searched. The data extraction was focussed on the biological activities of Pe-MNPs and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations for systematic reviews. Results A total of 15 studies outlined 7 biological activities of Pe-MNPs in the only three metals that have been explored, namely silver (Ag), gold (Au) and cerium oxide (CeO2). The activities reported from the in vitro and in vivo studies were antimicrobial (9 studies), anticancer (2 studies), drug carrier (3 studies), non-toxic (4 studies), antioxidant (2 studies), wound healing (1 study) and anti-inflammation (1 study). Conclusions This systematic review demonstrates the current state of the art of Pe-MNPs biological activities, suggesting that Ag and Au have potent antibacterial and anticancer/chemotherapeutic drug carrier activity, respectively. Further in vitro, in vivo, and clinical research is crucial for a better understanding of the pharmacological potential of pectin synthesised MNPs. |
| first_indexed | 2024-12-14T18:58:51Z |
| format | Article |
| id | doaj.art-277960406a5d4aef9f4a2c52b0d491b4 |
| institution | Directory Open Access Journal |
| issn | 1388-0209 1744-5116 |
| language | English |
| last_indexed | 2024-12-14T18:58:51Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Pharmaceutical Biology |
| spelling | doaj.art-277960406a5d4aef9f4a2c52b0d491b42022-12-21T22:51:00ZengTaylor & Francis GroupPharmaceutical Biology1388-02091744-51162021-01-0159149450310.1080/13880209.2021.19107161910716Green synthesis of metallic nanoparticles using pectin as a reducing agent: a systematic review of the biological activitiesKogilavanee Devasvaran0Vuanghao Lim1Integrative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains MalaysiaIntegrative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains MalaysiaContext Pectin is a plant heteropolysaccharide that is biocompatible and biodegradable, enabling it to be an excellent reducing agent (green synthesis) for metallic nanoparticles (MNPs). Nevertheless, in the biological industry, pectin has been left behind in synthesising MNPs, for no known reason. Objective To systematically review the biological activities of pectin synthesised MNPs (Pe-MNPs). Methods The databases Springer Link, Scopus, ScienceDirect, Google Scholar, PubMed, Mendeley, and ResearchGate were systematically searched from the date of their inception until 10th February 2020. Pectin, green synthesis, metallic nanoparticles, reducing agent and biological activities were among the key terms searched. The data extraction was focussed on the biological activities of Pe-MNPs and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations for systematic reviews. Results A total of 15 studies outlined 7 biological activities of Pe-MNPs in the only three metals that have been explored, namely silver (Ag), gold (Au) and cerium oxide (CeO2). The activities reported from the in vitro and in vivo studies were antimicrobial (9 studies), anticancer (2 studies), drug carrier (3 studies), non-toxic (4 studies), antioxidant (2 studies), wound healing (1 study) and anti-inflammation (1 study). Conclusions This systematic review demonstrates the current state of the art of Pe-MNPs biological activities, suggesting that Ag and Au have potent antibacterial and anticancer/chemotherapeutic drug carrier activity, respectively. Further in vitro, in vivo, and clinical research is crucial for a better understanding of the pharmacological potential of pectin synthesised MNPs.http://dx.doi.org/10.1080/13880209.2021.1910716polysacchariderhamnogalacturonan iantibacterialanticancerdrug carrierantioxidantwound healinganti-inflammatory |
| spellingShingle | Kogilavanee Devasvaran Vuanghao Lim Green synthesis of metallic nanoparticles using pectin as a reducing agent: a systematic review of the biological activities Pharmaceutical Biology polysaccharide rhamnogalacturonan i antibacterial anticancer drug carrier antioxidant wound healing anti-inflammatory |
| title | Green synthesis of metallic nanoparticles using pectin as a reducing agent: a systematic review of the biological activities |
| title_full | Green synthesis of metallic nanoparticles using pectin as a reducing agent: a systematic review of the biological activities |
| title_fullStr | Green synthesis of metallic nanoparticles using pectin as a reducing agent: a systematic review of the biological activities |
| title_full_unstemmed | Green synthesis of metallic nanoparticles using pectin as a reducing agent: a systematic review of the biological activities |
| title_short | Green synthesis of metallic nanoparticles using pectin as a reducing agent: a systematic review of the biological activities |
| title_sort | green synthesis of metallic nanoparticles using pectin as a reducing agent a systematic review of the biological activities |
| topic | polysaccharide rhamnogalacturonan i antibacterial anticancer drug carrier antioxidant wound healing anti-inflammatory |
| url | http://dx.doi.org/10.1080/13880209.2021.1910716 |
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