Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/21/11579 |
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| author | Aleksandra Rapacka-Zdonczyk Agata Wozniak Beata Kruszewska Krzysztof Waleron Mariusz Grinholc |
| author_facet | Aleksandra Rapacka-Zdonczyk Agata Wozniak Beata Kruszewska Krzysztof Waleron Mariusz Grinholc |
| author_sort | Aleksandra Rapacka-Zdonczyk |
| collection | DOAJ |
| description | Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential of tolerance/resistance development in <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, and <i>Pseudomonas aeruginosa</i> and demonstrated that representative Gram-negative bacteria may develop tolerance to aBL. The observed adaption was a stable feature. Assays involving <i>E. coli</i> K-12 <i>tolC</i>-, <i>tolA-</i>, <i>umuD-</i>, and <i>recA</i>-deficient mutants revealed some possible mechanisms for aBL tolerance development. |
| first_indexed | 2024-03-10T06:01:25Z |
| format | Article |
| id | doaj.art-277b9fb2658145eba85b9794167e0213 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:01:25Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-277b9fb2658145eba85b9794167e02132023-11-22T20:54:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122211157910.3390/ijms222111579Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?Aleksandra Rapacka-Zdonczyk0Agata Wozniak1Beata Kruszewska2Krzysztof Waleron3Mariusz Grinholc4Department of Pharmaceutical Microbiology, The Faculty of Pharmacy, Medical University of Gdansk, Hallera 107, 80-416 Gdansk, PolandLaboratory of Photobiology and Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, PolandDepartment of Pharmaceutical Microbiology, The Faculty of Pharmacy, Medical University of Gdansk, Hallera 107, 80-416 Gdansk, PolandDepartment of Pharmaceutical Microbiology, The Faculty of Pharmacy, Medical University of Gdansk, Hallera 107, 80-416 Gdansk, PolandLaboratory of Photobiology and Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, PolandAntimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential of tolerance/resistance development in <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, and <i>Pseudomonas aeruginosa</i> and demonstrated that representative Gram-negative bacteria may develop tolerance to aBL. The observed adaption was a stable feature. Assays involving <i>E. coli</i> K-12 <i>tolC</i>-, <i>tolA-</i>, <i>umuD-</i>, and <i>recA</i>-deficient mutants revealed some possible mechanisms for aBL tolerance development.https://www.mdpi.com/1422-0067/22/21/11579antimicrobial blue lightresistancetolerance<i>Escherichia coli</i><i>Klebsiella pneumoniae</i><i>Pseudomonas aeruginosa</i> |
| spellingShingle | Aleksandra Rapacka-Zdonczyk Agata Wozniak Beata Kruszewska Krzysztof Waleron Mariusz Grinholc Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment? International Journal of Molecular Sciences antimicrobial blue light resistance tolerance <i>Escherichia coli</i> <i>Klebsiella pneumoniae</i> <i>Pseudomonas aeruginosa</i> |
| title | Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment? |
| title_full | Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment? |
| title_fullStr | Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment? |
| title_full_unstemmed | Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment? |
| title_short | Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment? |
| title_sort | can gram negative bacteria develop resistance to antimicrobial blue light treatment |
| topic | antimicrobial blue light resistance tolerance <i>Escherichia coli</i> <i>Klebsiella pneumoniae</i> <i>Pseudomonas aeruginosa</i> |
| url | https://www.mdpi.com/1422-0067/22/21/11579 |
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