Five Autoimmune Gastritis Patients with Positive Findings of Serum Anti-parietal Cell Antibodies
Autoimmune gastritis is a corpus-dominant type of gastritis with positive serum anti-parietal cell antibodies (APCA) and/or anti-intrinsic factor antibodies. Serum APCA and pepsinogen (PG) assays were performed in subjects with corpus-dominant gastritis detected by endoscopy. Serum APCA was positive...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Yong Chan Lee
2021-09-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| Subjects: | |
| Online Access: | http://www.helicojournal.org/upload/pdf/kjhugr-2021-0016.pdf |
| _version_ | 1823936883325927424 |
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| author | Jong Hyeon Jeong Sun-Young Lee Hye Seung Han Jeong Hwan Kim In-Kyung Sung Hyung Seok Park |
| author_facet | Jong Hyeon Jeong Sun-Young Lee Hye Seung Han Jeong Hwan Kim In-Kyung Sung Hyung Seok Park |
| author_sort | Jong Hyeon Jeong |
| collection | DOAJ |
| description | Autoimmune gastritis is a corpus-dominant type of gastritis with positive serum anti-parietal cell antibodies (APCA) and/or anti-intrinsic factor antibodies. Serum APCA and pepsinogen (PG) assays were performed in subjects with corpus-dominant gastritis detected by endoscopy. Serum APCA was positive in five patients. All these patients were postmenopausal women (four Koreans and one Caucasian from the Russian Federation) with a mean age of 59.0±3.2 years. They displayed low PG I levels ranging from 8.1 to 18.8 ng/mL (mean, 11.4±4.8 ng/mL) and low PG I/II ratios ranging from 0.7 to 2.4 (mean, 1.2±0.7). Three of the patients were being treated for autoimmune thyroiditis. Multiple gastric neuroendocrine tumors were observed in two Helicobacter pylori (H. pylori)-naive patients with high serum gastrin levels exceeding 700 pg/mL and serum chromogranin A levels exceeding 1,000 ng/mL. In the remaining three patients, intestinal metaplasia was observed in the biopsied specimens from the antrum, suggesting a history of H. pylori infection. Our findings indicate the value of positive serum APCA findings, low serum PG I levels, and low serum PG I/II ratios in confirming autoimmune gastritis in patients showing corpus-dominant atrophy, regardless of their H. pylori infection status. |
| first_indexed | 2024-12-16T22:54:52Z |
| format | Article |
| id | doaj.art-277d81d2dbf047caa628e6265b1ac109 |
| institution | Directory Open Access Journal |
| issn | 1738-3331 |
| language | English |
| last_indexed | 2024-12-16T22:54:52Z |
| publishDate | 2021-09-01 |
| publisher | Yong Chan Lee |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj.art-277d81d2dbf047caa628e6265b1ac1092022-12-21T22:12:56ZengYong Chan LeeThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312021-09-0121322623410.7704/kjhugr.2021.0016680Five Autoimmune Gastritis Patients with Positive Findings of Serum Anti-parietal Cell AntibodiesJong Hyeon Jeong0Sun-Young Lee1Hye Seung Han2Jeong Hwan Kim3In-Kyung Sung4Hyung Seok Park5Department of Internal Medicine, Konkuk University School of Medicine, Seoul, KoreaDepartment of Internal Medicine, Konkuk University School of Medicine, Seoul, KoreaDepartment of Pathology, Konkuk University School of Medicine, Seoul, KoreaDepartment of Internal Medicine, Konkuk University School of Medicine, Seoul, KoreaDepartment of Internal Medicine, Konkuk University School of Medicine, Seoul, KoreaDepartment of Internal Medicine, Konkuk University School of Medicine, Seoul, KoreaAutoimmune gastritis is a corpus-dominant type of gastritis with positive serum anti-parietal cell antibodies (APCA) and/or anti-intrinsic factor antibodies. Serum APCA and pepsinogen (PG) assays were performed in subjects with corpus-dominant gastritis detected by endoscopy. Serum APCA was positive in five patients. All these patients were postmenopausal women (four Koreans and one Caucasian from the Russian Federation) with a mean age of 59.0±3.2 years. They displayed low PG I levels ranging from 8.1 to 18.8 ng/mL (mean, 11.4±4.8 ng/mL) and low PG I/II ratios ranging from 0.7 to 2.4 (mean, 1.2±0.7). Three of the patients were being treated for autoimmune thyroiditis. Multiple gastric neuroendocrine tumors were observed in two Helicobacter pylori (H. pylori)-naive patients with high serum gastrin levels exceeding 700 pg/mL and serum chromogranin A levels exceeding 1,000 ng/mL. In the remaining three patients, intestinal metaplasia was observed in the biopsied specimens from the antrum, suggesting a history of H. pylori infection. Our findings indicate the value of positive serum APCA findings, low serum PG I levels, and low serum PG I/II ratios in confirming autoimmune gastritis in patients showing corpus-dominant atrophy, regardless of their H. pylori infection status.http://www.helicojournal.org/upload/pdf/kjhugr-2021-0016.pdfatrophic gastritisautoimmune diseasesneuroendocrine tumorsparietal cells |
| spellingShingle | Jong Hyeon Jeong Sun-Young Lee Hye Seung Han Jeong Hwan Kim In-Kyung Sung Hyung Seok Park Five Autoimmune Gastritis Patients with Positive Findings of Serum Anti-parietal Cell Antibodies The Korean Journal of Helicobacter and Upper Gastrointestinal Research atrophic gastritis autoimmune diseases neuroendocrine tumors parietal cells |
| title | Five Autoimmune Gastritis Patients with Positive Findings of Serum Anti-parietal Cell Antibodies |
| title_full | Five Autoimmune Gastritis Patients with Positive Findings of Serum Anti-parietal Cell Antibodies |
| title_fullStr | Five Autoimmune Gastritis Patients with Positive Findings of Serum Anti-parietal Cell Antibodies |
| title_full_unstemmed | Five Autoimmune Gastritis Patients with Positive Findings of Serum Anti-parietal Cell Antibodies |
| title_short | Five Autoimmune Gastritis Patients with Positive Findings of Serum Anti-parietal Cell Antibodies |
| title_sort | five autoimmune gastritis patients with positive findings of serum anti parietal cell antibodies |
| topic | atrophic gastritis autoimmune diseases neuroendocrine tumors parietal cells |
| url | http://www.helicojournal.org/upload/pdf/kjhugr-2021-0016.pdf |
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