Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case–control study
Abstract Background Although several clinical studies have analysed the relationship between the levels of vascular endothelial growth factor (VEGF) and apelin-13 in venous blood and retinopathy of prematurity (ROP), no definitive conclusions have been reached. This study aimed to investigate the re...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-022-02565-x |
| _version_ | 1818499024074833920 |
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| author | Yimin Zhang Jing Feng Shuming Shao Qing Mu Jie Liu Chaomei Zeng Xiaorui Zhang |
| author_facet | Yimin Zhang Jing Feng Shuming Shao Qing Mu Jie Liu Chaomei Zeng Xiaorui Zhang |
| author_sort | Yimin Zhang |
| collection | DOAJ |
| description | Abstract Background Although several clinical studies have analysed the relationship between the levels of vascular endothelial growth factor (VEGF) and apelin-13 in venous blood and retinopathy of prematurity (ROP), no definitive conclusions have been reached. This study aimed to investigate the relationship between apelin-13 levels and VEGF levels and ROP. Methods Differences in plasma apelin-13 and VEGF levels were analysed in two groups of infants born with birth weight < 1500 g and gestational age < 32 weeks at Peking University People’ s Hospital. One group comprised infants diagnosed with ROP and the other group was a control group comprising infants without ROP. Results Apelin-13 levels were significantly lower in the ROP group than in the control group, while VEGF levels showed the opposite result (both P < 0.001). Infants with severe ROP had lower apelin-13 levels and higher VEGF levels than with mild ROP (both P < 0.05).The receiver operating characteristic curve for apelin-13 level as the indicator of ROP showed that a cut-off value of 119.6 pg/mL yielded a sensitivity of 84.8% and a specificity of 63.6%, while for VEGF level, the cut-off value of 84.3 pg/mL exhibited a sensitivity of 84.8% and a specificity of 66.7%. Conclusions Plasma apelin-13 and VEGF levels at 4–6 weeks of age may play a role in assisting the diagnosis of ROP. |
| first_indexed | 2024-12-10T20:23:34Z |
| format | Article |
| id | doaj.art-2780a19f6d1d498c81a7127eb0378573 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-10T20:23:34Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-2780a19f6d1d498c81a7127eb03785732022-12-22T01:34:56ZengBMCBMC Ophthalmology1471-24152022-08-012211810.1186/s12886-022-02565-xCorrelation between apelin and VEGF levels in retinopathy of prematurity: a matched case–control studyYimin Zhang0Jing Feng1Shuming Shao2Qing Mu3Jie Liu4Chaomei Zeng5Xiaorui Zhang6Department of Pediatrics, Peking University People’s HospitalDepartment of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical UniversityDepartment of Pediatrics, Peking University People’s HospitalDepartment of Central Laboratory & Institute of Clinical Molecular Biology, Peking University People’s HospitalDepartment of Pediatrics, Peking University People’s HospitalDepartment of Pediatrics, Peking University People’s HospitalDepartment of Pediatrics, Peking University People’s HospitalAbstract Background Although several clinical studies have analysed the relationship between the levels of vascular endothelial growth factor (VEGF) and apelin-13 in venous blood and retinopathy of prematurity (ROP), no definitive conclusions have been reached. This study aimed to investigate the relationship between apelin-13 levels and VEGF levels and ROP. Methods Differences in plasma apelin-13 and VEGF levels were analysed in two groups of infants born with birth weight < 1500 g and gestational age < 32 weeks at Peking University People’ s Hospital. One group comprised infants diagnosed with ROP and the other group was a control group comprising infants without ROP. Results Apelin-13 levels were significantly lower in the ROP group than in the control group, while VEGF levels showed the opposite result (both P < 0.001). Infants with severe ROP had lower apelin-13 levels and higher VEGF levels than with mild ROP (both P < 0.05).The receiver operating characteristic curve for apelin-13 level as the indicator of ROP showed that a cut-off value of 119.6 pg/mL yielded a sensitivity of 84.8% and a specificity of 63.6%, while for VEGF level, the cut-off value of 84.3 pg/mL exhibited a sensitivity of 84.8% and a specificity of 66.7%. Conclusions Plasma apelin-13 and VEGF levels at 4–6 weeks of age may play a role in assisting the diagnosis of ROP.https://doi.org/10.1186/s12886-022-02565-xApelin-13Vascular endothelial growth factorRetinopathy of prematurityPreterm infant |
| spellingShingle | Yimin Zhang Jing Feng Shuming Shao Qing Mu Jie Liu Chaomei Zeng Xiaorui Zhang Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case–control study BMC Ophthalmology Apelin-13 Vascular endothelial growth factor Retinopathy of prematurity Preterm infant |
| title | Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case–control study |
| title_full | Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case–control study |
| title_fullStr | Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case–control study |
| title_full_unstemmed | Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case–control study |
| title_short | Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case–control study |
| title_sort | correlation between apelin and vegf levels in retinopathy of prematurity a matched case control study |
| topic | Apelin-13 Vascular endothelial growth factor Retinopathy of prematurity Preterm infant |
| url | https://doi.org/10.1186/s12886-022-02565-x |
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