| Summary: | The development of multifunctional nanomaterials and devices for biomedical applications has garnered significant attention in recent years due to their potential to revolutionize healthcare. In this study, we report the synthesis and characterization of novel nanomaterials with tailored properties for targeted drug delivery, imaging, and biosensing applications. We employed a bottom-up approach to design and fabricate nanocomposites comprising of biocompatible polymers, metallic nanoparticles, and quantum dots, which exhibit unique optical, magnetic, and electronic properties. The nanocomposites were functionalized with specific ligands to enable active targeting of cancer cells and pathogens. We also developed microfluidic devices for the efficient capture and analysis of circulating tumor cells (CTCs) using the synthesized nanomaterials. The performance of the nanomaterials and devices was evaluated in vitro and in vivo, demonstrating enhanced drug delivery efficiency, high-resolution imaging, and sensitive biosensing capabilities. Furthermore, we investigated the biocompatibility and long-term stability of the nanomaterials in physiological conditions. Our findings indicate that the developed multifunctional nanomaterials and devices hold great promise for advancing personalized medicine, early diagnosis, and targeted therapy. This study provides a comprehensive understanding of the design principles and potential applications of multifunctional nanomaterials in the biomedical field, paving the way for future research and clinical translation.
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