Selective adjuvant radiation therapy for distant lymph node metastasis in patients with stage 4B epithelial ovarian cancer: a case series
Although the efficacy of surgery followed by taxane- and platinum-based systemic chemotherapy has been clearly demonstrated in the standard first-line treatment of epithelial ovarian cancer, the role of radiation therapy for distant lymph node metastasis in patients with epithelial ovarian cancer is...
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| Format: | Article |
| Language: | English |
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Kosin University College of Medicine
2023-12-01
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| Series: | Kosin Medical Journal |
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| Online Access: | http://www.kosinmedj.org/upload/pdf/kmj-23-146.pdf |
| _version_ | 1797372984272355328 |
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| author | Eun Taeg Kim Seung Yeon Oh Sun Young Ma Tae Hwa Lee Won Gyu Kim |
| author_facet | Eun Taeg Kim Seung Yeon Oh Sun Young Ma Tae Hwa Lee Won Gyu Kim |
| author_sort | Eun Taeg Kim |
| collection | DOAJ |
| description | Although the efficacy of surgery followed by taxane- and platinum-based systemic chemotherapy has been clearly demonstrated in the standard first-line treatment of epithelial ovarian cancer, the role of radiation therapy for distant lymph node metastasis in patients with epithelial ovarian cancer is not well-established due to a lack of reported studies. We identified four patients who underwent selective adjuvant radiation therapy for neck and para-aortic lymph node lesions after primary debulking surgery between 2020 and 2022, followed by platinum-based chemotherapy for stage 4B high-grade serous ovarian cancer. Through a retrospective review of medical records, we analyzed patient clinicopathologic features, treatment course, and imaging findings. The median age was 49.25 years (range, 46–54 years). All patients had the International Federation of Gynecology and Obstetrics stage 4B disease. Following primary debulking surgery, all patients received weekly paclitaxel-carboplatin chemotherapy and maintenance treatment with poly(ADP-ribose) polymerase (PARP) inhibitors. All patients received selective adjuvant radiation therapy for neck and para-aortic lymph node metastasis before PARP inhibitor maintenance. The median follow-up time was 36.75 months (range, 19–45 months). All patients achieved a complete response. None of the patients experienced disease recurrence or died during the follow-up period. The management of distant lymph node metastasis in patients with epithelial ovarian cancer remains a matter of debate. Selective adjuvant radiation therapy in first-line treatment for ovarian cancer appears to be a feasible approach with maintenance therapy for stage 4B epithelial ovarian cancer. |
| first_indexed | 2024-03-08T18:43:44Z |
| format | Article |
| id | doaj.art-27863a3df3d547158c85bcf9d58f4677 |
| institution | Directory Open Access Journal |
| issn | 2005-9531 2586-7024 |
| language | English |
| last_indexed | 2024-03-08T18:43:44Z |
| publishDate | 2023-12-01 |
| publisher | Kosin University College of Medicine |
| record_format | Article |
| series | Kosin Medical Journal |
| spelling | doaj.art-27863a3df3d547158c85bcf9d58f46772023-12-29T01:19:07ZengKosin University College of MedicineKosin Medical Journal2005-95312586-70242023-12-0138429329910.7180/kmj.23.1461264Selective adjuvant radiation therapy for distant lymph node metastasis in patients with stage 4B epithelial ovarian cancer: a case seriesEun Taeg Kim0Seung Yeon Oh1Sun Young Ma2Tae Hwa Lee3Won Gyu Kim4 Department of Obstetrics and Gynecology, Kosin University Gospel Hospital, Busan, Korea Department of Obstetrics and Gynecology, Kosin University Gospel Hospital, Busan, Korea Department of Radiology, Kosin University Gospel Hospital, Busan, Korea Department of Obstetrics and Gynecology, Kosin University Gospel Hospital, Busan, Korea Department of Obstetrics and Gynecology, Kosin University Gospel Hospital, Busan, KoreaAlthough the efficacy of surgery followed by taxane- and platinum-based systemic chemotherapy has been clearly demonstrated in the standard first-line treatment of epithelial ovarian cancer, the role of radiation therapy for distant lymph node metastasis in patients with epithelial ovarian cancer is not well-established due to a lack of reported studies. We identified four patients who underwent selective adjuvant radiation therapy for neck and para-aortic lymph node lesions after primary debulking surgery between 2020 and 2022, followed by platinum-based chemotherapy for stage 4B high-grade serous ovarian cancer. Through a retrospective review of medical records, we analyzed patient clinicopathologic features, treatment course, and imaging findings. The median age was 49.25 years (range, 46–54 years). All patients had the International Federation of Gynecology and Obstetrics stage 4B disease. Following primary debulking surgery, all patients received weekly paclitaxel-carboplatin chemotherapy and maintenance treatment with poly(ADP-ribose) polymerase (PARP) inhibitors. All patients received selective adjuvant radiation therapy for neck and para-aortic lymph node metastasis before PARP inhibitor maintenance. The median follow-up time was 36.75 months (range, 19–45 months). All patients achieved a complete response. None of the patients experienced disease recurrence or died during the follow-up period. The management of distant lymph node metastasis in patients with epithelial ovarian cancer remains a matter of debate. Selective adjuvant radiation therapy in first-line treatment for ovarian cancer appears to be a feasible approach with maintenance therapy for stage 4B epithelial ovarian cancer.http://www.kosinmedj.org/upload/pdf/kmj-23-146.pdfadjuvant radiotherapycase reportslymphatic metastasisovarian neoplasmspoly(adp-ribose) polymerase inhibitors |
| spellingShingle | Eun Taeg Kim Seung Yeon Oh Sun Young Ma Tae Hwa Lee Won Gyu Kim Selective adjuvant radiation therapy for distant lymph node metastasis in patients with stage 4B epithelial ovarian cancer: a case series Kosin Medical Journal adjuvant radiotherapy case reports lymphatic metastasis ovarian neoplasms poly(adp-ribose) polymerase inhibitors |
| title | Selective adjuvant radiation therapy for distant lymph node metastasis in patients with stage 4B epithelial ovarian cancer: a case series |
| title_full | Selective adjuvant radiation therapy for distant lymph node metastasis in patients with stage 4B epithelial ovarian cancer: a case series |
| title_fullStr | Selective adjuvant radiation therapy for distant lymph node metastasis in patients with stage 4B epithelial ovarian cancer: a case series |
| title_full_unstemmed | Selective adjuvant radiation therapy for distant lymph node metastasis in patients with stage 4B epithelial ovarian cancer: a case series |
| title_short | Selective adjuvant radiation therapy for distant lymph node metastasis in patients with stage 4B epithelial ovarian cancer: a case series |
| title_sort | selective adjuvant radiation therapy for distant lymph node metastasis in patients with stage 4b epithelial ovarian cancer a case series |
| topic | adjuvant radiotherapy case reports lymphatic metastasis ovarian neoplasms poly(adp-ribose) polymerase inhibitors |
| url | http://www.kosinmedj.org/upload/pdf/kmj-23-146.pdf |
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