(1<i>R</i>/<i>S</i>,7a<i>S</i>/<i>R</i>)-1-Benzyl-1-[2,8-bis(trifluoromethyl)quinolin-4-yl]-hexahydro-oxazolo[3,4-<i>a</i>]pyridin-3-one
An unexpected diastereoselective C-alkylation of a mefloquine derivative in up to 57% yield was the result of an attempted Williamson etherification of Boc-mefloquine. The domino reaction involved oxazolidinone ring closure, deprotonation, and stereoselective carbon–carbon bond formation. The struct...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-12-01
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Series: | Molbank |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-8599/2024/1/M1756 |