Selenomethionine against titanium particle-induced osteolysis by regulating the ROS-dependent NLRP3 inflammasome activation via the β-catenin signaling pathway

Selenomethionine against titanium particle-induced osteolysis by regulating the ROS-dependent NLRP3 inflammasome activation via the β-catenin signaling pathway

Wear debris-induced osteolysis, especially titanium (Ti) particles-induced osteolysis, is the most common cause of arthroplasty failure with no effective therapy. Previous studies have suggested that inflammation and impaired osteogenesis are associated with Ti particles -induced osteolysis. Seleniu...

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Bibliographic Details
Main Authors: Ruixuan Yu, Yongjian Yuan, Zhicheng Liu, Long Liu, Zhaoning Xu, Yunpeng Zhao, Chunwang Jia, Pengfei Zhang, Hang Li, Yuhao Liu, Yi Wang, Weiwei Li, Lin Nie, Xuecheng Sun, Yuhua Li, Ben Liu, Haichun Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
selenomethionine
titanium particle-induced osteolysis
β-catenin
inflammatory osteolysis
NLRP3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1171150/full

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