Enhancement of Chromatin and Epigenetic Reprogramming in Porcine SCNT Embryos—Progresses and Perspectives
Over the last 25 years, cloned animals have been produced by transferring somatic cell nuclei into enucleated oocytes (SCNT) in more than 20 mammalian species. Among domestic animals, pigs are likely the leading species in the number of clones produced by SCNT. The greater interest in pig cloning ha...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.940197/full |
| _version_ | 1811219274932420608 |
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| author | Werner Giehl Glanzner Mariana Priotto de Macedo Karina Gutierrez Vilceu Bordignon |
| author_facet | Werner Giehl Glanzner Mariana Priotto de Macedo Karina Gutierrez Vilceu Bordignon |
| author_sort | Werner Giehl Glanzner |
| collection | DOAJ |
| description | Over the last 25 years, cloned animals have been produced by transferring somatic cell nuclei into enucleated oocytes (SCNT) in more than 20 mammalian species. Among domestic animals, pigs are likely the leading species in the number of clones produced by SCNT. The greater interest in pig cloning has two main reasons, its relevance for food production and as its use as a suitable model in biomedical applications. Recognized progress in animal cloning has been attained over time, but the overall efficiency of SCNT in pigs remains very low, based on the rate of healthy, live born piglets following embryo transfer. Accumulating evidence from studies in mice and other species indicate that new strategies for promoting chromatin and epigenetic reprogramming may represent the beginning of a new era for pig cloning. |
| first_indexed | 2024-04-12T07:24:37Z |
| format | Article |
| id | doaj.art-278a17a1a4144555bd06fa736398615a |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-12T07:24:37Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-278a17a1a4144555bd06fa736398615a2022-12-22T03:42:14ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-07-011010.3389/fcell.2022.940197940197Enhancement of Chromatin and Epigenetic Reprogramming in Porcine SCNT Embryos—Progresses and PerspectivesWerner Giehl GlanznerMariana Priotto de MacedoKarina GutierrezVilceu BordignonOver the last 25 years, cloned animals have been produced by transferring somatic cell nuclei into enucleated oocytes (SCNT) in more than 20 mammalian species. Among domestic animals, pigs are likely the leading species in the number of clones produced by SCNT. The greater interest in pig cloning has two main reasons, its relevance for food production and as its use as a suitable model in biomedical applications. Recognized progress in animal cloning has been attained over time, but the overall efficiency of SCNT in pigs remains very low, based on the rate of healthy, live born piglets following embryo transfer. Accumulating evidence from studies in mice and other species indicate that new strategies for promoting chromatin and epigenetic reprogramming may represent the beginning of a new era for pig cloning.https://www.frontiersin.org/articles/10.3389/fcell.2022.940197/fullpigcloningSCNTembryo developmentchromatinepigenetics |
| spellingShingle | Werner Giehl Glanzner Mariana Priotto de Macedo Karina Gutierrez Vilceu Bordignon Enhancement of Chromatin and Epigenetic Reprogramming in Porcine SCNT Embryos—Progresses and Perspectives Frontiers in Cell and Developmental Biology pig cloning SCNT embryo development chromatin epigenetics |
| title | Enhancement of Chromatin and Epigenetic Reprogramming in Porcine SCNT Embryos—Progresses and Perspectives |
| title_full | Enhancement of Chromatin and Epigenetic Reprogramming in Porcine SCNT Embryos—Progresses and Perspectives |
| title_fullStr | Enhancement of Chromatin and Epigenetic Reprogramming in Porcine SCNT Embryos—Progresses and Perspectives |
| title_full_unstemmed | Enhancement of Chromatin and Epigenetic Reprogramming in Porcine SCNT Embryos—Progresses and Perspectives |
| title_short | Enhancement of Chromatin and Epigenetic Reprogramming in Porcine SCNT Embryos—Progresses and Perspectives |
| title_sort | enhancement of chromatin and epigenetic reprogramming in porcine scnt embryos progresses and perspectives |
| topic | pig cloning SCNT embryo development chromatin epigenetics |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.940197/full |
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