Self-organizing bioinspired oligothiophene–oligopeptide hybrids
In this minireview, we survey recent advances in the synthesis, characterization, and modeling of new oligothiophene–oligopeptide hybrids capable of forming nanostructured fibrillar aggregates in solution and on solid substrates. Compounds of this class are promising for applications because their s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Beilstein-Institut
2011-09-01
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| Series: | Beilstein Journal of Nanotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjnano.2.57 |
| _version_ | 1818478275578560512 |
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| author | Alexey K. Shaytan Eva-Kathrin Schillinger Elena Mena-Osteritz Sylvia Schmid Pavel G. Khalatur Peter Bäuerle Alexei R. Khokhlov |
| author_facet | Alexey K. Shaytan Eva-Kathrin Schillinger Elena Mena-Osteritz Sylvia Schmid Pavel G. Khalatur Peter Bäuerle Alexei R. Khokhlov |
| author_sort | Alexey K. Shaytan |
| collection | DOAJ |
| description | In this minireview, we survey recent advances in the synthesis, characterization, and modeling of new oligothiophene–oligopeptide hybrids capable of forming nanostructured fibrillar aggregates in solution and on solid substrates. Compounds of this class are promising for applications because their self-assembly and stimuli-responsive properties, provided by the peptide moieties combined with the semiconducting properties of the thiophene blocks, can result in novel opportunities for the design of advanced smart materials. These bio-inspired molecular hybrids are experimentally shown to form stable fibrils as visualized by AFM and TEM. While the experimental evidence alone is not sufficient to reveal the exact molecular organization of the fibrils, theoretical approaches based on quantum chemistry calculations and large-scale atomistic molecular dynamics simulations are attempted in an effort to reveal the structure of the fibrils at the nanoscale. Based on the combined theoretical and experimental analysis, the most likely models of fibril formation and aggregation are suggested. |
| first_indexed | 2024-12-10T09:45:52Z |
| format | Article |
| id | doaj.art-278a3c42a2f84bf29f03b4744eeebe7d |
| institution | Directory Open Access Journal |
| issn | 2190-4286 |
| language | English |
| last_indexed | 2024-12-10T09:45:52Z |
| publishDate | 2011-09-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Nanotechnology |
| spelling | doaj.art-278a3c42a2f84bf29f03b4744eeebe7d2022-12-22T01:53:50ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862011-09-012152554410.3762/bjnano.2.572190-4286-2-57Self-organizing bioinspired oligothiophene–oligopeptide hybridsAlexey K. Shaytan0Eva-Kathrin Schillinger1Elena Mena-Osteritz2Sylvia Schmid3Pavel G. Khalatur4Peter Bäuerle5Alexei R. Khokhlov6Institute of Polymer Science, University of Ulm, Albert-Einstein-Allee 47, D-89069 Ulm, GermanyInstitute of Organic Chemistry II and Advanced Materials, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, GermanyInstitute of Organic Chemistry II and Advanced Materials, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, GermanyInstitute of Organic Chemistry II and Advanced Materials, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, GermanyInstitute of Polymer Science, University of Ulm, Albert-Einstein-Allee 47, D-89069 Ulm, GermanyInstitute of Organic Chemistry II and Advanced Materials, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, GermanyInstitute of Polymer Science, University of Ulm, Albert-Einstein-Allee 47, D-89069 Ulm, GermanyIn this minireview, we survey recent advances in the synthesis, characterization, and modeling of new oligothiophene–oligopeptide hybrids capable of forming nanostructured fibrillar aggregates in solution and on solid substrates. Compounds of this class are promising for applications because their self-assembly and stimuli-responsive properties, provided by the peptide moieties combined with the semiconducting properties of the thiophene blocks, can result in novel opportunities for the design of advanced smart materials. These bio-inspired molecular hybrids are experimentally shown to form stable fibrils as visualized by AFM and TEM. While the experimental evidence alone is not sufficient to reveal the exact molecular organization of the fibrils, theoretical approaches based on quantum chemistry calculations and large-scale atomistic molecular dynamics simulations are attempted in an effort to reveal the structure of the fibrils at the nanoscale. Based on the combined theoretical and experimental analysis, the most likely models of fibril formation and aggregation are suggested.https://doi.org/10.3762/bjnano.2.57amyloid-like fibrilsbioinspired conjugatesmolecular dynamics simulationsoligopeptidesoligothiophenesself-assembly |
| spellingShingle | Alexey K. Shaytan Eva-Kathrin Schillinger Elena Mena-Osteritz Sylvia Schmid Pavel G. Khalatur Peter Bäuerle Alexei R. Khokhlov Self-organizing bioinspired oligothiophene–oligopeptide hybrids Beilstein Journal of Nanotechnology amyloid-like fibrils bioinspired conjugates molecular dynamics simulations oligopeptides oligothiophenes self-assembly |
| title | Self-organizing bioinspired oligothiophene–oligopeptide hybrids |
| title_full | Self-organizing bioinspired oligothiophene–oligopeptide hybrids |
| title_fullStr | Self-organizing bioinspired oligothiophene–oligopeptide hybrids |
| title_full_unstemmed | Self-organizing bioinspired oligothiophene–oligopeptide hybrids |
| title_short | Self-organizing bioinspired oligothiophene–oligopeptide hybrids |
| title_sort | self organizing bioinspired oligothiophene oligopeptide hybrids |
| topic | amyloid-like fibrils bioinspired conjugates molecular dynamics simulations oligopeptides oligothiophenes self-assembly |
| url | https://doi.org/10.3762/bjnano.2.57 |
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