Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells
The emergence of tumour adaptive radioresistance can limit the success of radiation therapy and immunotherapy in breast cancer. In this study, the authors demonstrate that CD47 and HER2 are coordinating in tumor response to radiation and that co-blockage of both receptors can eliminate radiorestista...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18245-7 |
| _version_ | 1818683205476155392 |
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| author | Demet Candas-Green Bowen Xie Jie Huang Ming Fan Aijun Wang Cheikh Menaa Yanhong Zhang Lu Zhang Di Jing Soheila Azghadi Weibing Zhou Lin Liu Nian Jiang Tao Li Tianyi Gao Colleen Sweeney Rulong Shen Tzu-yin Lin Chong-xian Pan Omer M. Ozpiskin Gayle Woloschak David J. Grdina Andrew T. Vaughan Ji Ming Wang Shuli Xia Arta M. Monjazeb William J. Murphy Lun-Quan Sun Hong-Wu Chen Kit S. Lam Ralph R. Weichselbaum Jian Jian Li |
| author_facet | Demet Candas-Green Bowen Xie Jie Huang Ming Fan Aijun Wang Cheikh Menaa Yanhong Zhang Lu Zhang Di Jing Soheila Azghadi Weibing Zhou Lin Liu Nian Jiang Tao Li Tianyi Gao Colleen Sweeney Rulong Shen Tzu-yin Lin Chong-xian Pan Omer M. Ozpiskin Gayle Woloschak David J. Grdina Andrew T. Vaughan Ji Ming Wang Shuli Xia Arta M. Monjazeb William J. Murphy Lun-Quan Sun Hong-Wu Chen Kit S. Lam Ralph R. Weichselbaum Jian Jian Li |
| author_sort | Demet Candas-Green |
| collection | DOAJ |
| description | The emergence of tumour adaptive radioresistance can limit the success of radiation therapy and immunotherapy in breast cancer. In this study, the authors demonstrate that CD47 and HER2 are coordinating in tumor response to radiation and that co-blockage of both receptors can eliminate radiorestistant breast cancer cells. |
| first_indexed | 2024-12-17T10:31:02Z |
| format | Article |
| id | doaj.art-278b23d810204e89b5b3f18e5d760fef |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:31:02Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-278b23d810204e89b5b3f18e5d760fef2022-12-21T21:52:31ZengNature PortfolioNature Communications2041-17232020-09-0111111510.1038/s41467-020-18245-7Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cellsDemet Candas-Green0Bowen Xie1Jie Huang2Ming Fan3Aijun Wang4Cheikh Menaa5Yanhong Zhang6Lu Zhang7Di Jing8Soheila Azghadi9Weibing Zhou10Lin Liu11Nian Jiang12Tao Li13Tianyi Gao14Colleen Sweeney15Rulong Shen16Tzu-yin Lin17Chong-xian Pan18Omer M. Ozpiskin19Gayle Woloschak20David J. Grdina21Andrew T. Vaughan22Ji Ming Wang23Shuli Xia24Arta M. Monjazeb25William J. Murphy26Lun-Quan Sun27Hong-Wu Chen28Kit S. Lam29Ralph R. Weichselbaum30Jian Jian Li31Department of Radiation Oncology, University of California DavisDepartment of Radiation Oncology, University of California DavisDepartment of Radiation Oncology, University of California DavisDepartment of Radiation Oncology, University of California DavisDepartment of Surgery, School of Medicine, University of California DavisDepartment of Radiation Oncology, University of California DavisDepartment of Pathology, Kaiser Permanente Medical Center Vallejo and VacavilleDepartment of Radiation Oncology, University of California DavisDepartment of Radiation Oncology, University of California DavisDepartment of Radiation Oncology, University of California DavisDepartment of Radiation Oncology, University of California DavisDepartment of Radiation Oncology, University of California DavisDepartment of Radiation Oncology, University of California DavisDepartment of Radiation Oncology, University of California DavisDepartment of Radiation Oncology, University of California DavisDepartment of Biochemistry and Molecular Medicine, University of California DavisDepartment of Pathology, Ohio State UniversityDepartment of Biochemistry and Molecular Medicine, University of California DavisNCI-Designated Comprehensive Cancer Center, University of California DavisDepartment of Radiation Oncology, University of California DavisDepartment of Radiation Oncology, Northwestern University, Feinberg School of MedicineDepartment of Radiation and Cellular Oncology and the Ludwig Center for Metastasis Research, The University of ChicagoDepartment of Radiation Oncology, University of California DavisChemoattractant Receptor and Signal Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer InstituteDepartment of Neurology, Johns Hopkins School of MedicineDepartment of Radiation Oncology, University of California DavisNCI-Designated Comprehensive Cancer Center, University of California DavisCenter for Molecular Medicine, Xiangya Hospital, Central South UniversityDepartment of Biochemistry and Molecular Medicine, University of California DavisDepartment of Biochemistry and Molecular Medicine, University of California DavisDepartment of Radiation and Cellular Oncology and the Ludwig Center for Metastasis Research, The University of ChicagoDepartment of Radiation Oncology, University of California DavisThe emergence of tumour adaptive radioresistance can limit the success of radiation therapy and immunotherapy in breast cancer. In this study, the authors demonstrate that CD47 and HER2 are coordinating in tumor response to radiation and that co-blockage of both receptors can eliminate radiorestistant breast cancer cells.https://doi.org/10.1038/s41467-020-18245-7 |
| spellingShingle | Demet Candas-Green Bowen Xie Jie Huang Ming Fan Aijun Wang Cheikh Menaa Yanhong Zhang Lu Zhang Di Jing Soheila Azghadi Weibing Zhou Lin Liu Nian Jiang Tao Li Tianyi Gao Colleen Sweeney Rulong Shen Tzu-yin Lin Chong-xian Pan Omer M. Ozpiskin Gayle Woloschak David J. Grdina Andrew T. Vaughan Ji Ming Wang Shuli Xia Arta M. Monjazeb William J. Murphy Lun-Quan Sun Hong-Wu Chen Kit S. Lam Ralph R. Weichselbaum Jian Jian Li Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells Nature Communications |
| title | Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells |
| title_full | Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells |
| title_fullStr | Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells |
| title_full_unstemmed | Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells |
| title_short | Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells |
| title_sort | dual blockade of cd47 and her2 eliminates radioresistant breast cancer cells |
| url | https://doi.org/10.1038/s41467-020-18245-7 |
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