Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity

Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity

Consumption of a hypercaloric diet upregulates microglial innate immune reactivity along with a higher expression of lipoprotein lipase (Lpl) within the reactive microglia in the mouse brain. Here, we show that knockdown of the Lpl gene specifically in microglia resulted in deficient microglial upta...

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Bibliographic Details
Main Authors: Yuanqing Gao, Andrés Vidal-Itriago, Martin J. Kalsbeek, Clarita Layritz, Cristina García-Cáceres, Robby Zachariah Tom, Thomas O. Eichmann, Frédéric M. Vaz, Riekelt H. Houtkooper, Nicole van der Wel, Arthur J. Verhoeven, Jie Yan, Andries Kalsbeek, Robert H. Eckel, Susanna M. Hofmann, Chun-Xia Yi
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
hypothalamus
very low-density lipoprotein
phagocytosis
phospholipid
mitochondria
fuel dependency
glutamine
TNF-α
NF-κB
autophagosomes
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471731269X

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