Modeling C3 glomerulopathies: C3 convertase regulation on an extracellular matrix surface
IntroductionC3 glomerulopathies (C3G) are ultra-rare complement-mediated diseases that lead to end-stage renal disease (ESRD) within 10 years of diagnosis in ~50% of patients. Overactivation of the alternative pathway (AP) of complement in the fluid phase and on the surface of the glomerular endothe...
Main Authors: | Sofiya Pisarenka, Nicole C. Meyer, Xue Xiao, Renee Goodfellow, Carla M. Nester, Yuzhou Zhang, Richard J. H. Smith |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-01-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1073802/full |
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