Applying Nanoparticles in the Treatment of Viral Infections and Toxicological Considerations
Background: Despite the tremendous progress in human medicine, viral infections can cause death in them. Due to the high prevalence of viruses, it is required to develop novel treatment strategies and provide the site-specific delivery of antiviral agents at the viral reservoirs. Objectives: Particl...
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| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2019-11-01
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| Series: | Pharmaceutical and Biomedical Research |
| Subjects: | |
| Online Access: | http://pbr.mazums.ac.ir/article-1-247-en.html |
| _version_ | 1818598060785139712 |
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| author | Zohreh Fasili Freshteh Mehri Hossein Ali Ebrahimi Zhaleh Jamali Elham Mohammad Khanlou Farzad Kahrizi Ahmad Salimi |
| author_facet | Zohreh Fasili Freshteh Mehri Hossein Ali Ebrahimi Zhaleh Jamali Elham Mohammad Khanlou Farzad Kahrizi Ahmad Salimi |
| author_sort | Zohreh Fasili |
| collection | DOAJ |
| description | Background: Despite the tremendous progress in human medicine, viral infections can cause death in them. Due to the high prevalence of viruses, it is required to develop novel treatment strategies and provide the site-specific delivery of antiviral agents at the viral reservoirs.
Objectives: Particle size is a vital physical characteristic that can affect the bioavailability and circulation time of nanoparticles. The ratio of large surface area and volume of nanoparticle could enhance the solubility of poorly soluble drug compounds.
Methods: Therefore, the optimum surface charge of the nanoparticle with the possibility of encapsulation and large drug cargo, are some of the nanoformulation advantages of these agents.
Results: This study reviewed various nanocarriers and modern smart delivery technologies, such as liposomes and immunoliposomes, polymeric nanoparticles, nanoemulsions, nanosuspensions, dendrimers, solid lipid nanoparticles, and so on.
Conclusion: We aimed to overcome the problems of traditional formulations and resistance to currently available therapies in various infections. Moreover, the concerns about the potential toxicities of nanoparticles to humans have been raised; therefore, the present study has reviewed the toxicity effects of nanoparticles used in controlling viral infections. |
| first_indexed | 2024-12-16T11:57:42Z |
| format | Article |
| id | doaj.art-278df6929830489abc6ba49b11f163e4 |
| institution | Directory Open Access Journal |
| issn | 2423-4494 |
| language | English |
| last_indexed | 2024-12-16T11:57:42Z |
| publishDate | 2019-11-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj.art-278df6929830489abc6ba49b11f163e42022-12-21T22:32:31ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44942019-11-0154120Applying Nanoparticles in the Treatment of Viral Infections and Toxicological ConsiderationsZohreh Fasili0Freshteh Mehri1Hossein Ali Ebrahimi2Zhaleh Jamali3Elham Mohammad Khanlou4Farzad Kahrizi5Ahmad Salimi6 Nutrition Health Research Center, Food and Drug Control Laboratory, Hamadan University of Medical Sciences, Hamadan, Iran. Nutrition Health Research Center, Food and Drug Control Laboratory, Hamadan University of Medical Sciences, Hamadan, Iran. Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran. Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran, Department of Addiction Studies, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran. Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran. Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran. Background: Despite the tremendous progress in human medicine, viral infections can cause death in them. Due to the high prevalence of viruses, it is required to develop novel treatment strategies and provide the site-specific delivery of antiviral agents at the viral reservoirs. Objectives: Particle size is a vital physical characteristic that can affect the bioavailability and circulation time of nanoparticles. The ratio of large surface area and volume of nanoparticle could enhance the solubility of poorly soluble drug compounds. Methods: Therefore, the optimum surface charge of the nanoparticle with the possibility of encapsulation and large drug cargo, are some of the nanoformulation advantages of these agents. Results: This study reviewed various nanocarriers and modern smart delivery technologies, such as liposomes and immunoliposomes, polymeric nanoparticles, nanoemulsions, nanosuspensions, dendrimers, solid lipid nanoparticles, and so on. Conclusion: We aimed to overcome the problems of traditional formulations and resistance to currently available therapies in various infections. Moreover, the concerns about the potential toxicities of nanoparticles to humans have been raised; therefore, the present study has reviewed the toxicity effects of nanoparticles used in controlling viral infections.http://pbr.mazums.ac.ir/article-1-247-en.htmlnanoparticlesdrug deliverynanomedicinetoxicityantiviral |
| spellingShingle | Zohreh Fasili Freshteh Mehri Hossein Ali Ebrahimi Zhaleh Jamali Elham Mohammad Khanlou Farzad Kahrizi Ahmad Salimi Applying Nanoparticles in the Treatment of Viral Infections and Toxicological Considerations Pharmaceutical and Biomedical Research nanoparticles drug delivery nanomedicine toxicity antiviral |
| title | Applying Nanoparticles in the Treatment of Viral Infections and Toxicological Considerations |
| title_full | Applying Nanoparticles in the Treatment of Viral Infections and Toxicological Considerations |
| title_fullStr | Applying Nanoparticles in the Treatment of Viral Infections and Toxicological Considerations |
| title_full_unstemmed | Applying Nanoparticles in the Treatment of Viral Infections and Toxicological Considerations |
| title_short | Applying Nanoparticles in the Treatment of Viral Infections and Toxicological Considerations |
| title_sort | applying nanoparticles in the treatment of viral infections and toxicological considerations |
| topic | nanoparticles drug delivery nanomedicine toxicity antiviral |
| url | http://pbr.mazums.ac.ir/article-1-247-en.html |
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