Survival of Respiratory Failure within the First 72 Hours in Preterm Infants with Respiratory Distress Based on the Downes Score Assessment
Background: Respiratory distress in neonates is the most common condition of preterm infants receiving treatment in the neonatal intensive care unit. As a clinical assessment of respiratory distress, the Downes score can predict the risk of respiratory failure. The present study aimed to determine t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2022-04-01
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| Series: | Iranian Journal of Neonatology |
| Subjects: | |
| Online Access: | https://ijn.mums.ac.ir/article_19787_f92180cb173cd4fabf71233dcd190642.pdf |
| _version_ | 1811336067200057344 |
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| author | Wedi Iskandar Hana Sofia Rachman Vidi Permata Galih Forestiera Indikurnia Muhammad Hafizh |
| author_facet | Wedi Iskandar Hana Sofia Rachman Vidi Permata Galih Forestiera Indikurnia Muhammad Hafizh |
| author_sort | Wedi Iskandar |
| collection | DOAJ |
| description | Background: Respiratory distress in neonates is the most common condition of preterm infants receiving treatment in the neonatal intensive care unit. As a clinical assessment of respiratory distress, the Downes score can predict the risk of respiratory failure. The present study aimed to determine the survival of respiratory failure in the first 72 h in preterm infants with respiratory distress based on the Downes score assessment.Methods: A prospective cohort survival analysis was performed at three hospitals in Indonesia (Al-Islam Hospital, Bandung, Al-Ihsan Hospital, Bandung, and Cibabat Hospital, Cimahi) from April to July 2021. Subjects were infants aged 28-36 weeks, with respiratory distress based on the Downes score within the first 2, 6, 12, 24, 48, and 72 h after delivery. The analyzed variables included birth weight ([BW], <1500 vs. 1500-2500 g), gestational age ([GA], 28-32 vs. 32-37 weeks), and 5-min APGAR score (<7 vs. >7). Bivariate and multivariate analyses were conducted with Cox regression proportional hazard and the Kaplan-Meier estimate of survival rate was also performed. In addition, the adjusted hazard ratio (aHR) was calculated, and a P-value of less than 0.05 was considered statistically significant.Results: Of the 89 subjects who met the criteria, 20 (22.47%) experienced respiratory failure. The multivariate analysis including BW (aHR: 1.846, 95%CI: 0.570-5.979, P> 0.05), GA (aHR: 2.273, 95 %CI: 0.697-7.416, P>0.05), and the 5-min APGAR score (aHR: 2.049, 95%CI: 0.811-5.179, P>0.05) estimated the survival rate for respiratory failure at the age of 72 h at 74.7% (standard error: 0.05%).Conclusion: A GA of <32 weeks, a BW of <1500 g, and the condition of asphyxia simultaneously increased the aHR of respiratory failure, with an estimated survival rate of 74.7%. |
| first_indexed | 2024-04-13T17:33:58Z |
| format | Article |
| id | doaj.art-279135d2a2de4cc0988a1648df6d618c |
| institution | Directory Open Access Journal |
| issn | 2251-7510 2322-2158 |
| language | English |
| last_indexed | 2024-04-13T17:33:58Z |
| publishDate | 2022-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Neonatology |
| spelling | doaj.art-279135d2a2de4cc0988a1648df6d618c2022-12-22T02:37:27ZengMashhad University of Medical SciencesIranian Journal of Neonatology2251-75102322-21582022-04-011321710.22038/ijn.2022.59690.213319787Survival of Respiratory Failure within the First 72 Hours in Preterm Infants with Respiratory Distress Based on the Downes Score AssessmentWedi Iskandar0Hana Sofia Rachman1Vidi Permata Galih2Forestiera Indikurnia3Muhammad Hafizh4Child Health Laboratory, Faculty of Medicine, Universitas Islam, Bandung, Indonesia. Al-Islam Hospital, Bandung, IndonesiaChild Health Laboratory, Faculty of Medicine, Universitas Islam, Bandung, Indonesia Al-Ihsan Regional General Hospital, Bandung, IndonesiaAl-Islam Hospital, Bandung, IndonesiaMedical Student, Faculty of Medicine, Universitas Islam, Bandung, IndonesiaMedical Student, Faculty of Medicine, Universitas Islam, Bandung, IndonesiaBackground: Respiratory distress in neonates is the most common condition of preterm infants receiving treatment in the neonatal intensive care unit. As a clinical assessment of respiratory distress, the Downes score can predict the risk of respiratory failure. The present study aimed to determine the survival of respiratory failure in the first 72 h in preterm infants with respiratory distress based on the Downes score assessment.Methods: A prospective cohort survival analysis was performed at three hospitals in Indonesia (Al-Islam Hospital, Bandung, Al-Ihsan Hospital, Bandung, and Cibabat Hospital, Cimahi) from April to July 2021. Subjects were infants aged 28-36 weeks, with respiratory distress based on the Downes score within the first 2, 6, 12, 24, 48, and 72 h after delivery. The analyzed variables included birth weight ([BW], <1500 vs. 1500-2500 g), gestational age ([GA], 28-32 vs. 32-37 weeks), and 5-min APGAR score (<7 vs. >7). Bivariate and multivariate analyses were conducted with Cox regression proportional hazard and the Kaplan-Meier estimate of survival rate was also performed. In addition, the adjusted hazard ratio (aHR) was calculated, and a P-value of less than 0.05 was considered statistically significant.Results: Of the 89 subjects who met the criteria, 20 (22.47%) experienced respiratory failure. The multivariate analysis including BW (aHR: 1.846, 95%CI: 0.570-5.979, P> 0.05), GA (aHR: 2.273, 95 %CI: 0.697-7.416, P>0.05), and the 5-min APGAR score (aHR: 2.049, 95%CI: 0.811-5.179, P>0.05) estimated the survival rate for respiratory failure at the age of 72 h at 74.7% (standard error: 0.05%).Conclusion: A GA of <32 weeks, a BW of <1500 g, and the condition of asphyxia simultaneously increased the aHR of respiratory failure, with an estimated survival rate of 74.7%.https://ijn.mums.ac.ir/article_19787_f92180cb173cd4fabf71233dcd190642.pdfdownes scorepreterm infantsrespiratory failure |
| spellingShingle | Wedi Iskandar Hana Sofia Rachman Vidi Permata Galih Forestiera Indikurnia Muhammad Hafizh Survival of Respiratory Failure within the First 72 Hours in Preterm Infants with Respiratory Distress Based on the Downes Score Assessment Iranian Journal of Neonatology downes score preterm infants respiratory failure |
| title | Survival of Respiratory Failure within the First 72 Hours in Preterm Infants with Respiratory Distress Based on the Downes Score Assessment |
| title_full | Survival of Respiratory Failure within the First 72 Hours in Preterm Infants with Respiratory Distress Based on the Downes Score Assessment |
| title_fullStr | Survival of Respiratory Failure within the First 72 Hours in Preterm Infants with Respiratory Distress Based on the Downes Score Assessment |
| title_full_unstemmed | Survival of Respiratory Failure within the First 72 Hours in Preterm Infants with Respiratory Distress Based on the Downes Score Assessment |
| title_short | Survival of Respiratory Failure within the First 72 Hours in Preterm Infants with Respiratory Distress Based on the Downes Score Assessment |
| title_sort | survival of respiratory failure within the first 72 hours in preterm infants with respiratory distress based on the downes score assessment |
| topic | downes score preterm infants respiratory failure |
| url | https://ijn.mums.ac.ir/article_19787_f92180cb173cd4fabf71233dcd190642.pdf |
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