The association between blood MxA mRNA and long-term disease activity in early multiple sclerosis
BackgroundMyxovirus resistance protein A (MxA) is a protein that is upregulated by interferon-beta. Homeostatic MxA mRNA levels are potentially correlated with inflammatory disease activity in multiple sclerosis (MS) and could have an important role in MS pathology.AimTo investigate the association...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.907245/full |
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| author | Eline M. E. Coerver Eva M. M. Strijbis Laura F. Petzold Zoé L. E. Van Kempen Bas Jasperse Frederik Barkhof Frederik Barkhof Cees B. M. Oudejans Bernard M. J. Uitdehaag Charlotte E. Teunissen Joep Killestein |
| author_facet | Eline M. E. Coerver Eva M. M. Strijbis Laura F. Petzold Zoé L. E. Van Kempen Bas Jasperse Frederik Barkhof Frederik Barkhof Cees B. M. Oudejans Bernard M. J. Uitdehaag Charlotte E. Teunissen Joep Killestein |
| author_sort | Eline M. E. Coerver |
| collection | DOAJ |
| description | BackgroundMyxovirus resistance protein A (MxA) is a protein that is upregulated by interferon-beta. Homeostatic MxA mRNA levels are potentially correlated with inflammatory disease activity in multiple sclerosis (MS) and could have an important role in MS pathology.AimTo investigate the association between myxovirus resistance protein A (MxA) mRNA levels in blood and disease activity and progression in MS over a long-term follow-up period.MethodsBaseline blood MxA mRNA levels were determined in a prospective cohort of 116 untreated patients with a clinically isolated syndrome (CIS) or early relapsing remitting MS (RRMS), and related to long-term relapses, radiological disease activity, clinical scores [Expanded Disability Status Scale (EDSS), timed-25-foot walk (T25FW), 9-hole-peg test (9HPT)], MS type, and disease modifying therapy (DMT) use.ResultsLow MxA mRNA levels were associated with the occurrence of ≥9 T2-lesions on MRI imaging and the occurrence of relapses during long-term follow-up (median 11 years, IQR 5.91–13.69 years). MxA mRNA levels were not associated with EDSS, T25FW, 9HPT, and MS subtype.ConclusionBaseline MxA mRNA levels are associated with long-term development of T2-lesions on MRI-scans in our cohort. This confirms the relevance of the endogenous interferon-beta system in the occurrence of MS disease activity. |
| first_indexed | 2024-04-13T13:13:44Z |
| format | Article |
| id | doaj.art-2792785ccbba4c5595114d676a093686 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T13:13:44Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-2792785ccbba4c5595114d676a0936862022-12-22T02:45:32ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-08-011310.3389/fneur.2022.907245907245The association between blood MxA mRNA and long-term disease activity in early multiple sclerosisEline M. E. Coerver0Eva M. M. Strijbis1Laura F. Petzold2Zoé L. E. Van Kempen3Bas Jasperse4Frederik Barkhof5Frederik Barkhof6Cees B. M. Oudejans7Bernard M. J. Uitdehaag8Charlotte E. Teunissen9Joep Killestein10Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Neurology, Maidstone and Tunbridge Wells NHS Trust, Kent, United KingdomDepartment of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsCentre for Medical Image Computing, Queen Square Institute of Neurology, University College London, London, United KingdomMolecular Biology Laboratory, Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsNeurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsBackgroundMyxovirus resistance protein A (MxA) is a protein that is upregulated by interferon-beta. Homeostatic MxA mRNA levels are potentially correlated with inflammatory disease activity in multiple sclerosis (MS) and could have an important role in MS pathology.AimTo investigate the association between myxovirus resistance protein A (MxA) mRNA levels in blood and disease activity and progression in MS over a long-term follow-up period.MethodsBaseline blood MxA mRNA levels were determined in a prospective cohort of 116 untreated patients with a clinically isolated syndrome (CIS) or early relapsing remitting MS (RRMS), and related to long-term relapses, radiological disease activity, clinical scores [Expanded Disability Status Scale (EDSS), timed-25-foot walk (T25FW), 9-hole-peg test (9HPT)], MS type, and disease modifying therapy (DMT) use.ResultsLow MxA mRNA levels were associated with the occurrence of ≥9 T2-lesions on MRI imaging and the occurrence of relapses during long-term follow-up (median 11 years, IQR 5.91–13.69 years). MxA mRNA levels were not associated with EDSS, T25FW, 9HPT, and MS subtype.ConclusionBaseline MxA mRNA levels are associated with long-term development of T2-lesions on MRI-scans in our cohort. This confirms the relevance of the endogenous interferon-beta system in the occurrence of MS disease activity.https://www.frontiersin.org/articles/10.3389/fneur.2022.907245/fulldemyelinating diseasemultiple sclerosisMRImyxovirus resistance protein A (MxA)mRNA |
| spellingShingle | Eline M. E. Coerver Eva M. M. Strijbis Laura F. Petzold Zoé L. E. Van Kempen Bas Jasperse Frederik Barkhof Frederik Barkhof Cees B. M. Oudejans Bernard M. J. Uitdehaag Charlotte E. Teunissen Joep Killestein The association between blood MxA mRNA and long-term disease activity in early multiple sclerosis Frontiers in Neurology demyelinating disease multiple sclerosis MRI myxovirus resistance protein A (MxA) mRNA |
| title | The association between blood MxA mRNA and long-term disease activity in early multiple sclerosis |
| title_full | The association between blood MxA mRNA and long-term disease activity in early multiple sclerosis |
| title_fullStr | The association between blood MxA mRNA and long-term disease activity in early multiple sclerosis |
| title_full_unstemmed | The association between blood MxA mRNA and long-term disease activity in early multiple sclerosis |
| title_short | The association between blood MxA mRNA and long-term disease activity in early multiple sclerosis |
| title_sort | association between blood mxa mrna and long term disease activity in early multiple sclerosis |
| topic | demyelinating disease multiple sclerosis MRI myxovirus resistance protein A (MxA) mRNA |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.907245/full |
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