High-efficiency RNA-based reprogramming of human primary fibroblasts
Induced pluripotent stem cells (iPSCs) have potential for regenerative medicine applications, but are generated with very low efficiency. Here, the authors show highly efficient reprogramming of human primary fibroblasts to iPSCs via the synergistic activity of synthetic modified mRNAs, mature miRNA...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03190-3 |
| _version_ | 1818750534303088640 |
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| author | Igor Kogut Sandra M. McCarthy Maryna Pavlova David P. Astling Xiaomi Chen Ana Jakimenko Kenneth L. Jones Andrew Getahun John C. Cambier Anna M. G. Pasmooij Marcel F. Jonkman Dennis R. Roop Ganna Bilousova |
| author_facet | Igor Kogut Sandra M. McCarthy Maryna Pavlova David P. Astling Xiaomi Chen Ana Jakimenko Kenneth L. Jones Andrew Getahun John C. Cambier Anna M. G. Pasmooij Marcel F. Jonkman Dennis R. Roop Ganna Bilousova |
| author_sort | Igor Kogut |
| collection | DOAJ |
| description | Induced pluripotent stem cells (iPSCs) have potential for regenerative medicine applications, but are generated with very low efficiency. Here, the authors show highly efficient reprogramming of human primary fibroblasts to iPSCs via the synergistic activity of synthetic modified mRNAs, mature miRNA mimics, and optimized culture methods. |
| first_indexed | 2024-12-18T04:21:12Z |
| format | Article |
| id | doaj.art-279523f467794ff7bb0f3d426b9968a3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:21:12Z |
| publishDate | 2018-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-279523f467794ff7bb0f3d426b9968a32022-12-21T21:21:14ZengNature PortfolioNature Communications2041-17232018-02-019111510.1038/s41467-018-03190-3High-efficiency RNA-based reprogramming of human primary fibroblastsIgor Kogut0Sandra M. McCarthy1Maryna Pavlova2David P. Astling3Xiaomi Chen4Ana Jakimenko5Kenneth L. Jones6Andrew Getahun7John C. Cambier8Anna M. G. Pasmooij9Marcel F. Jonkman10Dennis R. Roop11Ganna Bilousova12Department of Dermatology, University of Colorado School of MedicineDepartment of Dermatology, University of Colorado School of MedicineDepartment of Dermatology, University of Colorado School of MedicineDepartment of Biochemistry and Molecular Genetics, University of Colorado School of MedicineDepartment of Dermatology, University of Colorado School of MedicineDepartment of Dermatology, University of Colorado School of MedicineDepartment of Pediatrics, University of Colorado School of MedicineDepartment of Immunology and Microbiology, University of Colorado School of MedicineDepartment of Immunology and Microbiology, University of Colorado School of MedicineDepartment of Dermatology, University Medical CenterDepartment of Dermatology, University Medical CenterDepartment of Dermatology, University of Colorado School of MedicineDepartment of Dermatology, University of Colorado School of MedicineInduced pluripotent stem cells (iPSCs) have potential for regenerative medicine applications, but are generated with very low efficiency. Here, the authors show highly efficient reprogramming of human primary fibroblasts to iPSCs via the synergistic activity of synthetic modified mRNAs, mature miRNA mimics, and optimized culture methods.https://doi.org/10.1038/s41467-018-03190-3 |
| spellingShingle | Igor Kogut Sandra M. McCarthy Maryna Pavlova David P. Astling Xiaomi Chen Ana Jakimenko Kenneth L. Jones Andrew Getahun John C. Cambier Anna M. G. Pasmooij Marcel F. Jonkman Dennis R. Roop Ganna Bilousova High-efficiency RNA-based reprogramming of human primary fibroblasts Nature Communications |
| title | High-efficiency RNA-based reprogramming of human primary fibroblasts |
| title_full | High-efficiency RNA-based reprogramming of human primary fibroblasts |
| title_fullStr | High-efficiency RNA-based reprogramming of human primary fibroblasts |
| title_full_unstemmed | High-efficiency RNA-based reprogramming of human primary fibroblasts |
| title_short | High-efficiency RNA-based reprogramming of human primary fibroblasts |
| title_sort | high efficiency rna based reprogramming of human primary fibroblasts |
| url | https://doi.org/10.1038/s41467-018-03190-3 |
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