Effect of Vitamin A, C and zinc Supplementations on Oxidant-Antioxidant and Clinical Indices in Rheumatoid Arthritis Patients: A Randomized Control Trial
Background & Objectives: oxygen free radicals have been implicated as mediators of tissue damage in RA patients. This study was aimed to find the effects of vitamin A, C and zinc supplementations on oxidant–antioxidant, inflammatory and clinical indices in inactive RA patients.Methods: We design...
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| Format: | Article |
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Tehran University of Medical Sciences
2009-12-01
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| Series: | مجله اپیدمیولوژی ایران |
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| Online Access: | http://irje.tums.ac.ir/browse.php?a_code=A-10-25-105&slc_lang=en&sid=1 |
| _version_ | 1818388472511070208 |
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| author | S Athari Nik Azm MR Vafa I Nourmohammadi A Bidari A Hoshyarrad SH Jazayeri F Hoseini M Fasihi Radmandi |
| author_facet | S Athari Nik Azm MR Vafa I Nourmohammadi A Bidari A Hoshyarrad SH Jazayeri F Hoseini M Fasihi Radmandi |
| author_sort | S Athari Nik Azm |
| collection | DOAJ |
| description | Background & Objectives: oxygen free radicals have been implicated as mediators of tissue damage in RA patients. This study was aimed to find the effects of vitamin A, C and zinc supplementations on oxidant–antioxidant, inflammatory and clinical indices in inactive RA patients.Methods: We designed a randomized controlled trial. Forty nine (49) patients were randomly allocated in two groups; group I received their conventional treatment plus 300 mg vitamin C, 5 mg Zinc daily and 25000 IU vitamin A every other day for 12 weeks, group II received their conventional treatment only for the same duration. Disease activity (using the rheumatoid arthritis disease activity index (RADAI) score), biochemical indices [malondialdehyde (MDA), total antioxidant capacity (TAC)] and inflammatory markers [erythrocyte sedimentation rate (ESR), c-reactive protein (CRP)] was evaluated before and after 12 weeks.
Results: Serum concentration of MDA and RADAI score (P<0.0001) and ESR (P=0.033) were significantly decreased and TAC levels (P<0.0001) were significantly increased in the first group in comparison to second group after 12 weeks. However, there were no statistically significant differences in serum CRP concentration of two groups (P>0.05).
Conclusions: This study indicates that adding antioxidants as supplementations with conventional medications in inactive RA patients plays an important role in improving oxidative stress and decreasing disease activity and inflammatory status. |
| first_indexed | 2024-12-14T04:26:23Z |
| format | Article |
| id | doaj.art-27981d9209cc47ad8e1feac2c0a30c7c |
| institution | Directory Open Access Journal |
| issn | 1735-7489 2228-7507 |
| language | fas |
| last_indexed | 2024-12-14T04:26:23Z |
| publishDate | 2009-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | مجله اپیدمیولوژی ایران |
| spelling | doaj.art-27981d9209cc47ad8e1feac2c0a30c7c2022-12-21T23:17:12ZfasTehran University of Medical Sciencesمجله اپیدمیولوژی ایران1735-74892228-75072009-12-01531421Effect of Vitamin A, C and zinc Supplementations on Oxidant-Antioxidant and Clinical Indices in Rheumatoid Arthritis Patients: A Randomized Control TrialS Athari Nik Azm0MR Vafa1I Nourmohammadi2A Bidari3A Hoshyarrad4SH Jazayeri5F Hoseini6M Fasihi Radmandi7 Background & Objectives: oxygen free radicals have been implicated as mediators of tissue damage in RA patients. This study was aimed to find the effects of vitamin A, C and zinc supplementations on oxidant–antioxidant, inflammatory and clinical indices in inactive RA patients.Methods: We designed a randomized controlled trial. Forty nine (49) patients were randomly allocated in two groups; group I received their conventional treatment plus 300 mg vitamin C, 5 mg Zinc daily and 25000 IU vitamin A every other day for 12 weeks, group II received their conventional treatment only for the same duration. Disease activity (using the rheumatoid arthritis disease activity index (RADAI) score), biochemical indices [malondialdehyde (MDA), total antioxidant capacity (TAC)] and inflammatory markers [erythrocyte sedimentation rate (ESR), c-reactive protein (CRP)] was evaluated before and after 12 weeks. Results: Serum concentration of MDA and RADAI score (P<0.0001) and ESR (P=0.033) were significantly decreased and TAC levels (P<0.0001) were significantly increased in the first group in comparison to second group after 12 weeks. However, there were no statistically significant differences in serum CRP concentration of two groups (P>0.05). Conclusions: This study indicates that adding antioxidants as supplementations with conventional medications in inactive RA patients plays an important role in improving oxidative stress and decreasing disease activity and inflammatory status.http://irje.tums.ac.ir/browse.php?a_code=A-10-25-105&slc_lang=en&sid=1Rheumatoid arthritisOxidative stressAntioxidants |
| spellingShingle | S Athari Nik Azm MR Vafa I Nourmohammadi A Bidari A Hoshyarrad SH Jazayeri F Hoseini M Fasihi Radmandi Effect of Vitamin A, C and zinc Supplementations on Oxidant-Antioxidant and Clinical Indices in Rheumatoid Arthritis Patients: A Randomized Control Trial مجله اپیدمیولوژی ایران Rheumatoid arthritis Oxidative stress Antioxidants |
| title | Effect of Vitamin A, C and zinc Supplementations on Oxidant-Antioxidant and Clinical Indices in Rheumatoid Arthritis Patients: A Randomized Control Trial |
| title_full | Effect of Vitamin A, C and zinc Supplementations on Oxidant-Antioxidant and Clinical Indices in Rheumatoid Arthritis Patients: A Randomized Control Trial |
| title_fullStr | Effect of Vitamin A, C and zinc Supplementations on Oxidant-Antioxidant and Clinical Indices in Rheumatoid Arthritis Patients: A Randomized Control Trial |
| title_full_unstemmed | Effect of Vitamin A, C and zinc Supplementations on Oxidant-Antioxidant and Clinical Indices in Rheumatoid Arthritis Patients: A Randomized Control Trial |
| title_short | Effect of Vitamin A, C and zinc Supplementations on Oxidant-Antioxidant and Clinical Indices in Rheumatoid Arthritis Patients: A Randomized Control Trial |
| title_sort | effect of vitamin a c and zinc supplementations on oxidant antioxidant and clinical indices in rheumatoid arthritis patients a randomized control trial |
| topic | Rheumatoid arthritis Oxidative stress Antioxidants |
| url | http://irje.tums.ac.ir/browse.php?a_code=A-10-25-105&slc_lang=en&sid=1 |
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