Protein-modified nanomaterials: emerging trends in skin wound healing
Abstract Prolonged inflammation can impede wound healing, which is regulated by several proteins and cytokines, including IL-4, IL-10, IL-13, and TGF-β. Concentration-dependent effects of these molecules at the target site have been investigated by researchers to develop them as wound-healing agents...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2023-10-01
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| Series: | Discover Nano |
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| Online Access: | https://doi.org/10.1186/s11671-023-03903-8 |
| _version_ | 1827633382948864000 |
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| author | Deepinder Sharda Pawandeep Kaur Diptiman Choudhury |
| author_facet | Deepinder Sharda Pawandeep Kaur Diptiman Choudhury |
| author_sort | Deepinder Sharda |
| collection | DOAJ |
| description | Abstract Prolonged inflammation can impede wound healing, which is regulated by several proteins and cytokines, including IL-4, IL-10, IL-13, and TGF-β. Concentration-dependent effects of these molecules at the target site have been investigated by researchers to develop them as wound-healing agents by regulating signaling strength. Nanotechnology has provided a promising approach to achieve tissue-targeted delivery and increased effective concentration by developing protein-functionalized nanoparticles with growth factors (EGF, IGF, FGF, PDGF, TGF-β, TNF-α, and VEGF), antidiabetic wound-healing agents (insulin), and extracellular proteins (keratin, heparin, and silk fibroin). These molecules play critical roles in promoting cell proliferation, migration, ECM production, angiogenesis, and inflammation regulation. Therefore, protein-functionalized nanoparticles have emerged as a potential strategy for improving wound healing in delayed or impaired healing cases. This review summarizes the preparation and applications of these nanoparticles for normal or diabetic wound healing and highlights their potential to enhance wound healing. Graphical abstract |
| first_indexed | 2024-03-09T14:58:49Z |
| format | Article |
| id | doaj.art-279c760b1e7349979494293bfabc0517 |
| institution | Directory Open Access Journal |
| issn | 2731-9229 |
| language | English |
| last_indexed | 2024-03-09T14:58:49Z |
| publishDate | 2023-10-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Nano |
| spelling | doaj.art-279c760b1e7349979494293bfabc05172023-11-26T14:01:16ZengSpringerDiscover Nano2731-92292023-10-0118113610.1186/s11671-023-03903-8Protein-modified nanomaterials: emerging trends in skin wound healingDeepinder Sharda0Pawandeep Kaur1Diptiman Choudhury2School of Chemistry and Biochemistry, Thapar Institute of Engineering and TechnologySchool of Chemistry and Biochemistry, Thapar Institute of Engineering and TechnologySchool of Chemistry and Biochemistry, Thapar Institute of Engineering and TechnologyAbstract Prolonged inflammation can impede wound healing, which is regulated by several proteins and cytokines, including IL-4, IL-10, IL-13, and TGF-β. Concentration-dependent effects of these molecules at the target site have been investigated by researchers to develop them as wound-healing agents by regulating signaling strength. Nanotechnology has provided a promising approach to achieve tissue-targeted delivery and increased effective concentration by developing protein-functionalized nanoparticles with growth factors (EGF, IGF, FGF, PDGF, TGF-β, TNF-α, and VEGF), antidiabetic wound-healing agents (insulin), and extracellular proteins (keratin, heparin, and silk fibroin). These molecules play critical roles in promoting cell proliferation, migration, ECM production, angiogenesis, and inflammation regulation. Therefore, protein-functionalized nanoparticles have emerged as a potential strategy for improving wound healing in delayed or impaired healing cases. This review summarizes the preparation and applications of these nanoparticles for normal or diabetic wound healing and highlights their potential to enhance wound healing. Graphical abstracthttps://doi.org/10.1186/s11671-023-03903-8Wound healingNanoformulationsGrowth factorsProteinsAntidiabetic agents |
| spellingShingle | Deepinder Sharda Pawandeep Kaur Diptiman Choudhury Protein-modified nanomaterials: emerging trends in skin wound healing Discover Nano Wound healing Nanoformulations Growth factors Proteins Antidiabetic agents |
| title | Protein-modified nanomaterials: emerging trends in skin wound healing |
| title_full | Protein-modified nanomaterials: emerging trends in skin wound healing |
| title_fullStr | Protein-modified nanomaterials: emerging trends in skin wound healing |
| title_full_unstemmed | Protein-modified nanomaterials: emerging trends in skin wound healing |
| title_short | Protein-modified nanomaterials: emerging trends in skin wound healing |
| title_sort | protein modified nanomaterials emerging trends in skin wound healing |
| topic | Wound healing Nanoformulations Growth factors Proteins Antidiabetic agents |
| url | https://doi.org/10.1186/s11671-023-03903-8 |
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