Sirtuins Modulation: A Promising Strategy for HIV-Associated Neurocognitive Impairments
HIV-Associated neurocognitive disorder (HAND) is one of the major concerns since it persists in 40% of this population. Nowadays, HAND neuropathogenesis is considered to be caused by the infected cells that cross the brain–blood barrier and produce viral proteins that can be secreted and internalize...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/2/643 |
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| author | Izchel Figarola-Centurión Martha Escoto-Delgadillo Gracia Viviana González-Enríquez Juan Ernesto Gutiérrez-Sevilla Eduardo Vázquez-Valls Blanca Miriam Torres-Mendoza |
| author_facet | Izchel Figarola-Centurión Martha Escoto-Delgadillo Gracia Viviana González-Enríquez Juan Ernesto Gutiérrez-Sevilla Eduardo Vázquez-Valls Blanca Miriam Torres-Mendoza |
| author_sort | Izchel Figarola-Centurión |
| collection | DOAJ |
| description | HIV-Associated neurocognitive disorder (HAND) is one of the major concerns since it persists in 40% of this population. Nowadays, HAND neuropathogenesis is considered to be caused by the infected cells that cross the brain–blood barrier and produce viral proteins that can be secreted and internalized into neurons leading to disruption of cellular processes. The evidence points to viral proteins such as Tat as the causal agent for neuronal alteration and thus HAND. The hallmarks in Tat-induced neurodegeneration are endoplasmic reticulum stress and mitochondrial dysfunction. Sirtuins (SIRTs) are NAD+-dependent deacetylases involved in mitochondria biogenesis, unfolded protein response, and intrinsic apoptosis pathway. Tat interaction with these deacetylases causes inhibition of SIRT1 and SIRT3. Studies revealed that SIRTs activation promotes neuroprotection in neurodegenerative diseases such Alzheimer’s and Parkinson’s disease. Therefore, this review focuses on Tat-induced neurotoxicity mechanisms that involve SIRTs as key regulators and their modulation as a therapeutic strategy for tackling HAND and thereby improving the quality of life of people living with HIV. |
| first_indexed | 2024-03-10T01:19:46Z |
| format | Article |
| id | doaj.art-279cb575442144f28a87bd83a47e5281 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:19:46Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-279cb575442144f28a87bd83a47e52812023-11-23T14:01:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-0123264310.3390/ijms23020643Sirtuins Modulation: A Promising Strategy for HIV-Associated Neurocognitive ImpairmentsIzchel Figarola-Centurión0Martha Escoto-Delgadillo1Gracia Viviana González-Enríquez2Juan Ernesto Gutiérrez-Sevilla3Eduardo Vázquez-Valls4Blanca Miriam Torres-Mendoza5Doctorado en Genética Humana, Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Guadalajara 44340, MexicoLaboratorio de Inmunodeficiencias y Retrovirus Humanos, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, MexicoDepartamento de Disciplinas Filosófico, Metodológicas e Instrumentales, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, MexicoLaboratorio de Inmunodeficiencias y Retrovirus Humanos, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, MexicoGeneración de Recursos Profesionales, Investigación y Desarrollo, Secretaria de Salud, Jalisco, Guadalajara 44100, MexicoLaboratorio de Inmunodeficiencias y Retrovirus Humanos, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, MexicoHIV-Associated neurocognitive disorder (HAND) is one of the major concerns since it persists in 40% of this population. Nowadays, HAND neuropathogenesis is considered to be caused by the infected cells that cross the brain–blood barrier and produce viral proteins that can be secreted and internalized into neurons leading to disruption of cellular processes. The evidence points to viral proteins such as Tat as the causal agent for neuronal alteration and thus HAND. The hallmarks in Tat-induced neurodegeneration are endoplasmic reticulum stress and mitochondrial dysfunction. Sirtuins (SIRTs) are NAD+-dependent deacetylases involved in mitochondria biogenesis, unfolded protein response, and intrinsic apoptosis pathway. Tat interaction with these deacetylases causes inhibition of SIRT1 and SIRT3. Studies revealed that SIRTs activation promotes neuroprotection in neurodegenerative diseases such Alzheimer’s and Parkinson’s disease. Therefore, this review focuses on Tat-induced neurotoxicity mechanisms that involve SIRTs as key regulators and their modulation as a therapeutic strategy for tackling HAND and thereby improving the quality of life of people living with HIV.https://www.mdpi.com/1422-0067/23/2/643sirtuinSIRT1SIRT3SIRT2HIVresveratrol |
| spellingShingle | Izchel Figarola-Centurión Martha Escoto-Delgadillo Gracia Viviana González-Enríquez Juan Ernesto Gutiérrez-Sevilla Eduardo Vázquez-Valls Blanca Miriam Torres-Mendoza Sirtuins Modulation: A Promising Strategy for HIV-Associated Neurocognitive Impairments International Journal of Molecular Sciences sirtuin SIRT1 SIRT3 SIRT2 HIV resveratrol |
| title | Sirtuins Modulation: A Promising Strategy for HIV-Associated Neurocognitive Impairments |
| title_full | Sirtuins Modulation: A Promising Strategy for HIV-Associated Neurocognitive Impairments |
| title_fullStr | Sirtuins Modulation: A Promising Strategy for HIV-Associated Neurocognitive Impairments |
| title_full_unstemmed | Sirtuins Modulation: A Promising Strategy for HIV-Associated Neurocognitive Impairments |
| title_short | Sirtuins Modulation: A Promising Strategy for HIV-Associated Neurocognitive Impairments |
| title_sort | sirtuins modulation a promising strategy for hiv associated neurocognitive impairments |
| topic | sirtuin SIRT1 SIRT3 SIRT2 HIV resveratrol |
| url | https://www.mdpi.com/1422-0067/23/2/643 |
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