Parent Acceptance toward Inactivated COVID-19 Vaccination in Children with Acute Lymphoblastic Leukemia: The Power of Oncologist and Alliance
Objectives: The current study aims to survey the willingness of parents to vaccinate their children, who are childhood acute lymphoblastic leukemia survivors (CALLS), and identify factors associated with vaccine acceptance. Methods: Parents of CALLS on/off treatment, with the general condition of be...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/12/2016 |
| _version_ | 1797455017440968704 |
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| author | Yifei Ma Nianqi Liu Guanqing Zhong Dao Wang Lu Cao Shenrui Bai Pengfei Zhu Ao Zhang Xinjia Wang |
| author_facet | Yifei Ma Nianqi Liu Guanqing Zhong Dao Wang Lu Cao Shenrui Bai Pengfei Zhu Ao Zhang Xinjia Wang |
| author_sort | Yifei Ma |
| collection | DOAJ |
| description | Objectives: The current study aims to survey the willingness of parents to vaccinate their children, who are childhood acute lymphoblastic leukemia survivors (CALLS), and identify factors associated with vaccine acceptance. Methods: Parents of CALLS on/off treatment, with the general condition of being amendable to vaccination, were recruited for interviews with attending oncologists about COVID-19 vaccination acceptance from July to November 2021 in China. After controlling for socioeconomic factors, the Association of Oncologists’ recommendations and parent–oncologist alliance with acceptance status were investigated. For validation, propensity score-matched (PSM) analysis was used. Results: A total of 424 families were included in the study, with CALLS mean remission age of 5.99 ± 3.40 years. Among them, 91 (21.4%) agreed, 168 (39.6%) hesitated, and 165 (38.9%) parents disagreed with the vaccination. The most common reason that kept parents from vaccinating their children was lack of recommendations from professional personnel (84/165, 50.9%), and massive amounts of internet information (78/175, 44.6%) was the main nonhealthcare resource against vaccination. Logistic regression analysis showed that only the recommendation from the oncologist was associated with parents’ vaccine acceptance (OR = 3.17, 95% CI = 1.93–5.20), as demonstrated by PSM comparison (42 in recommendation group vs. 18 in nonrecommendation group among 114 pairs, <i>p</i> < 0.001). An exploratory analysis revealed that parents with a better patient–oncologist alliance had a significantly higher level of acceptance (65.6% in alliance group vs. 15.6% in nonalliance group among 32 pairs, <i>p</i> < 0.001). Conclusions: Due to a lack of professional recommendation resources and the potential for serious consequences, parents were generally reluctant to vaccinate their CALLS. The recommendation of oncologists, which was influenced by the parent–oncologist alliance, significantly increased acceptance. This study emphasizes the critical role of oncologists in vaccinating cancer survivors and can be used to promote COVID-19 vaccines among vulnerable populations. |
| first_indexed | 2024-03-09T15:45:31Z |
| format | Article |
| id | doaj.art-279f5813037f4487ae125ce1920cfff8 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T15:45:31Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-279f5813037f4487ae125ce1920cfff82023-11-24T18:31:15ZengMDPI AGVaccines2076-393X2022-11-011012201610.3390/vaccines10122016Parent Acceptance toward Inactivated COVID-19 Vaccination in Children with Acute Lymphoblastic Leukemia: The Power of Oncologist and AllianceYifei Ma0Nianqi Liu1Guanqing Zhong2Dao Wang3Lu Cao4Shenrui Bai5Pengfei Zhu6Ao Zhang7Xinjia Wang8Department of Orthopedics and Spine Surgery, The Second Affiliated Hospital of Shantou University Medical College, 69 Dongsha North Road, Shantou 515000, ChinaFaculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan 430074, ChinaDepartment of Clinical Laboratory, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, ChinaDepartment of Hematological Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, ChinaDepartment of Clinical Laboratory, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, ChinaDepartment of Orthopedics and Spine Surgery, The Second Affiliated Hospital of Shantou University Medical College, 69 Dongsha North Road, Shantou 515000, ChinaObjectives: The current study aims to survey the willingness of parents to vaccinate their children, who are childhood acute lymphoblastic leukemia survivors (CALLS), and identify factors associated with vaccine acceptance. Methods: Parents of CALLS on/off treatment, with the general condition of being amendable to vaccination, were recruited for interviews with attending oncologists about COVID-19 vaccination acceptance from July to November 2021 in China. After controlling for socioeconomic factors, the Association of Oncologists’ recommendations and parent–oncologist alliance with acceptance status were investigated. For validation, propensity score-matched (PSM) analysis was used. Results: A total of 424 families were included in the study, with CALLS mean remission age of 5.99 ± 3.40 years. Among them, 91 (21.4%) agreed, 168 (39.6%) hesitated, and 165 (38.9%) parents disagreed with the vaccination. The most common reason that kept parents from vaccinating their children was lack of recommendations from professional personnel (84/165, 50.9%), and massive amounts of internet information (78/175, 44.6%) was the main nonhealthcare resource against vaccination. Logistic regression analysis showed that only the recommendation from the oncologist was associated with parents’ vaccine acceptance (OR = 3.17, 95% CI = 1.93–5.20), as demonstrated by PSM comparison (42 in recommendation group vs. 18 in nonrecommendation group among 114 pairs, <i>p</i> < 0.001). An exploratory analysis revealed that parents with a better patient–oncologist alliance had a significantly higher level of acceptance (65.6% in alliance group vs. 15.6% in nonalliance group among 32 pairs, <i>p</i> < 0.001). Conclusions: Due to a lack of professional recommendation resources and the potential for serious consequences, parents were generally reluctant to vaccinate their CALLS. The recommendation of oncologists, which was influenced by the parent–oncologist alliance, significantly increased acceptance. This study emphasizes the critical role of oncologists in vaccinating cancer survivors and can be used to promote COVID-19 vaccines among vulnerable populations.https://www.mdpi.com/2076-393X/10/12/2016COIVD-19 vaccineparent acceptancevaccination hesitancyoncologist recommendationpatient–oncologist allianceacute lymphoblastic leukemia |
| spellingShingle | Yifei Ma Nianqi Liu Guanqing Zhong Dao Wang Lu Cao Shenrui Bai Pengfei Zhu Ao Zhang Xinjia Wang Parent Acceptance toward Inactivated COVID-19 Vaccination in Children with Acute Lymphoblastic Leukemia: The Power of Oncologist and Alliance Vaccines COIVD-19 vaccine parent acceptance vaccination hesitancy oncologist recommendation patient–oncologist alliance acute lymphoblastic leukemia |
| title | Parent Acceptance toward Inactivated COVID-19 Vaccination in Children with Acute Lymphoblastic Leukemia: The Power of Oncologist and Alliance |
| title_full | Parent Acceptance toward Inactivated COVID-19 Vaccination in Children with Acute Lymphoblastic Leukemia: The Power of Oncologist and Alliance |
| title_fullStr | Parent Acceptance toward Inactivated COVID-19 Vaccination in Children with Acute Lymphoblastic Leukemia: The Power of Oncologist and Alliance |
| title_full_unstemmed | Parent Acceptance toward Inactivated COVID-19 Vaccination in Children with Acute Lymphoblastic Leukemia: The Power of Oncologist and Alliance |
| title_short | Parent Acceptance toward Inactivated COVID-19 Vaccination in Children with Acute Lymphoblastic Leukemia: The Power of Oncologist and Alliance |
| title_sort | parent acceptance toward inactivated covid 19 vaccination in children with acute lymphoblastic leukemia the power of oncologist and alliance |
| topic | COIVD-19 vaccine parent acceptance vaccination hesitancy oncologist recommendation patient–oncologist alliance acute lymphoblastic leukemia |
| url | https://www.mdpi.com/2076-393X/10/12/2016 |
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